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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | The importance of using the cerebral function monitor(CFM) in the neurological prognosis of neonates in intensive care显示文摘 | Romeo MG Tina LG Gilauro S | 1998 | Pediat Med Chir1998，20，3： | 1 |
| 3 | Small-scale embledded generation effect on voltage profile an analytical method显示文摘 | Conti S Retiere N Tina G | 2003 | IEE Proceedings Generation Transmission and Distribution2003，150，2： | 1 |
| 4 | Hybrid solar/wind power system probabilistic modelling for long-term performance assessment 显示文摘 | Tina G Gagliano S Raiti S | 2006 | Solar Energy2006，80，5： | 1 |
| 5 | Hybrid solar/wind power system probabilistic modeling for long-term performance assessment显示文摘 | Tina G Gagliano S Raiti S | 2006 | Solar Energy2006，80，5： | 1 |
| 6 | Prevalence of aspirin resistance in patients with an evolving acute myocardial infarction 显示文摘 | TIna S Bo J Lars K | 2007 | Thromb Res2007，119，5： | 1 |
| 7 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
| 8 | Combination radiofrequeney and diode laser for treatment of facial rhytides and skin laxity显示文摘 | Seeman Doshi & Tina S Alster | 2005 | Cosmet Laser Ther2005，7，： | 1 |
| 9 | Human β-Defensins suppress human immunodeficiency virus infection:potential role in mucosal protection显示文摘 | Lingling S Catherine MF Tina KC | 2005 | Journal of Virology2005，79，14： | 1 |
| 10 | Hybrid solar/wind power system probabilistic modeling for long-term performance assessment显示文摘 | TINA G M GAGLIANO S RAITI S | 2006 | Solar Energy2006，80，57： | 1 |
| 11 | High throughput sequencing of microRNAs in chicken somites显示文摘 | Tina R Helio P Dylan S | 2009 | FEBS Letters2009，，583： | 1 |
| 12 | Ground-penetrating radar investigation of active faults along the Dead Sea Transform and implication for seismic hazards within the city of Aqaba, Jordan显示文摘 | Lee S Tina M N | 2003 | Tectonophysics2003，368，： | 1 |
| 13 | Xylanases in wheat separation显示文摘 | Claus C Andersen Erik Tina S J | 1997 | Starch/Starke1997，，49： | 1 |
| 14 | Small-scale embedded generation effect on voltage profile:an analytical method显示文摘 | Conti S Raiti S Tina G | 2003 | IEE Proceedings-Generation Transmis-sion and Distribution2003，150，1： | 1 |
| 15 | Condon engineering for improved antibody expression in mammalian cells 显示文摘 | Jill M C Tina S Pam H N | 2007 | Pro- tein Expression and Purification2007，55，2： | 1 |
| 16 | Peripheral blood fibrocyte- s:Differentiation pathwayand migration to wound sites显示文摘 | Abe R Bucala R Donnelly S Tina P | 2001 | The Journal of Immunology2001，166，： | 1 |
| 17 | Dynamic asset allocation under mean-reverting returns, stocbastic interest rates and inflation uncertainty- Are popular recommendations consistent with rational behavior? 显示文摘 | Claus Munk Carsten S?rensen Tina Nygaard Vinther | 2004 | International Review of Economics and Finance2004，2004，： | 1 |
| 18 | Treatment of keliod sternotomy scars with 585nm flashlamp-pumpedplulsed- dyelaser显示文摘 | Tina S Alster Carmen M Williams | 1995 | Lancet1995，345，： | 1 |
| 19 | Effects of surface area, free volume, and heat of adsorption on hydrogen uptake in metal-organic frameworks 显示文摘 | Houston F Tina D Randall Q S | 2006 | Phys Chem B2006，110，： | 1 |
| 20 | Laser treatment of Hypertrophic scar, Keloids and striae 显示文摘 | Tina S Alster | 1997 | LASERS In DERMATOLOGY1997，15，3： | 1 |
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