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| 1 | Juicy Stories on Female Reproductive Tissue Development: Coordinating the Hormone Flows显示文摘In the past 20–30 years,developmental biologists have made tremendous progress in identifying genes required for the specifcation of individual cell types of an organ and in describing how they interact in genetic networks.In comparison,very little is known about the mechanisms that regulate tissue polarity and overall organ patterning.Gynoecia and fruits from members of the Brassicaceae family of fowering plants provide excellent model systems to study organ patterning and tissue specifcation because they become partitioned into distinct domains whose formation is determined by polarity establishment both at a cellular and whole tissue level.Interactions among key regulators of Arabidopsis gynoecium and fruit development have revealed a network of upstream transcription factor activities required for such tissue differentiation.Regulation of the plant hormone auxin is emerging as both an immediate downstream output and input of these activities,and here we aim to provide an overview of the current knowledge regarding the link between auxin and female reproductive development in plants.In this review,we will also demonstrate how available data can be exploited in a mathematical modeling approach to reveal and understand the feedback regulatory circuits that underpin the polarity establishment,necessary to guide auxin flows. | Veronica A.Grieneisen Athanasius F.M.Marée Lars φstergaard | 2013 | Journal of Integrative Plant Biology2013，55，9： | 2 |
| 2 | Temperature Modulates Tissue-Specification Program to Control Fruit Dehiscence in Brassicaceae显示文摘植物对作出回应日报、季节在由 reprogramming 的温度的变化重要发展小径。理解定义植物生长和复制的环境调整在气候的上下文是批评的分子的机制改变那威胁世界范围的庄稼产量。这里,我们报导提高的温度包括模型植物 Arabidopsis thaliana 和重要庄稼种类在 Brassicaceae 家庭的成员加速水果裂开。Arabidopsis 水果开发被交往的规章的基因的一个网络控制。在他们之中, INDEHISCENT (IND ) 基因是调停的阀门边缘织物的一个关键管理者水果洞,因此便于水果裂开。我们证明阀门边缘发展在更高的温度被加速并且 IND 为 thermosensory 控制被指向。我们的结果表明 IND upregulation 经由导致加速的阀门边缘说明和种子的疏开的导致温度的染色质动力学被便于。明确地,我们证明在 IND 表示的导致温度的变化与 thermosensory H2A.Z nucleosome 动力学被联系。这些调查结果建立与热察觉到连接织物身份的一个分子的框架并且为温度有弹性的庄稼的生产提出方向。 | Xin-Ran Li Joyita Deb S. Vinod Kumar Lars Фstergaard | 2018 | Molecular Plant2018，11，4： | 2 |
| 3 | The structure of the small laccase from Streptomyces coelicolor reveals a link between laccases and nitrite reductases显示文摘 | Tereza Skálová Jan Dohnálek Lars Henrik stergaard | 2009 | Journal of Molecular Biology2009，385，4： | 1 |
| 4 | Mycoplasma genitalium: prevalence and behavioural risk factors in the general population显示文摘 | Andersen B Sokolowshi I Lars Stergaard | 2007 | Sex Transm Infect2007，83，3： | 1 |
| 5 | Mycoplasma genitalium: prevalence and behavioral risk factors in the general population 显示文摘 | Andersen B Sokolowshi I Lars Stergaard | 2007 | Sex Transm Infect2007，83，3： | 1 |
| 6 | A rich TILLING resource for studying gene function in Brassica rapa显示文摘 | Pauline S David B Lars stergaard | 2010 | BMC Plant Biol2010，10，： | 1 |
| 7 | Acceptable noise level (ANL) with Danish and non-semantic speech materials in adult hearing-aid users显示文摘 | Steen ? stergaard Olsen Johannes Lantz Lars Holme Nielsen K. Jonas Br? nnstr? m | 2012 | International Journal of Audiology2012，，9： | 1 |
| 8 | Mycoplasma genitalium:prevalence and behavioural risk factors in the general population 显示文摘 | Andersen B Sokolowshi I Lars stergaard | 2007 | Sex Transm Infect2007，83，3： | 1 |
| 9 | Systems Biology Approach Pinpoints Minimum Requirements for Auxin Distribution during Fruit Opening显示文摘The phytohormone auxin is implied in steering various developmental decisions during plant morphogenesis in a concentration-dependent manner.Auxin maxima have been shown to maintain meristematic activity,for example,of the root apical meristem,and position new sites of outgrowth,such as during lateral root initiation and phyllotaxis.More recently,it has been demonstrated that sites of auxin minima also provide positional information.In the developingArabidopsis fruit,auxin minima are required for correct differentiation of the valve margin.It remains unclear,however,how this auxin minimum is generated and maintained.Here,we employ a systems biology approach to model auxin transport based on experimental observations.This allows us to determine the minimal requirements for its establishment.Our simulations reveal that two alternative processes-which we coin 'flux-barrier' and 'flux-passage'-are both able to generate an auxin minimum,but under different parameter settings.Both models are in principle able to yield similar auxin profiles but present qualitatively distinct patterns of auxin flux.The models were tested by tissue-specific inducible ablation,revealing that the auxin minimum in the fruit is most likely generated by a flux-passage process.Model predictions were further supported through 3D PIN localization imaging and implementing experimentally observed transporter localization.Through such an experimental-modeling cycle,we predict how the auxin minimum gradually matures during fruit development to ensure timely fruit opening and seed dispersal. | Xin-Ran Li Renske M.A.Vroomans Samantha Fox Veronica A.Grieneisen Lars Φstergaard Athanasius F.M.Maree | 2019 | Molecular Plant2019，12，6： | 0 |
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