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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Testing the metals hypothesis in Spokane, Washington显示文摘 | CLAIBORN C S LARSON T SHEPPARD L | 2002 | Environ Health Perspect2002，110，4： | 1 |
| 4 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 5 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses显示文摘 | WEIGHT C J LARSON B T FERGANY A F | 2010 | J Urol2010，183，4： | 1 |
| 6 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 7 | Electrical resistivity of thin epitaxially grown silver films 显示文摘 | LARSON D C BOIKO B T | 1964 | Applied Physics Letters1964，5，： | 1 |
| 8 | Ne- phrectomy induced chronic renal insufficiency is associ- ated with increased risk of cardiovascular death and death from any cause in patients with localized cTlb re- nal masses显示文摘 | Weight C J Larson B T Fergany A F | 2010 | J Urol2010，183，4： | 1 |
| 9 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in pa- tients with localized cTlb renal masses 显示文摘 | Weight C J Larson B T Fergany A F Gao T Lane B R Campbell S C | 2010 | J Urol2010，183，： | 1 |
| 10 | Aqueous phase oxidation of sulfites by ozone in the presence of iron and manganese显示文摘 | HARRISON H LARSON T V MONKMAN C S | 1982 | Atmospheric Environment1982，16，5： | 1 |
| 11 | Elective partial nephrectomy in pa tients with clinical Tlb renal tumors is associated with improved overall survivaI显示文摘 | Weight C J Larson B T Gao T Campbell S C Lane B R Kaouk J H | 2010 | Urology2010，76，： | 1 |
| 12 | Elective partial nephrectomy in pa- tients with clinical Tlb renal tumors is associated with improved overall survival显示文摘 | Weight C J Larson B T Gao T Campbell S C Lane B R Kaouk J H | 2010 | Urology2010，76，： | 1 |
| 13 | Manganese superoxide dismutase can reduce cellular damage mediated by oxygen radicals in transgenic plants显示文摘 | Bowler C Slooten L Larson T J | 1991 | EMBO J1991，10，： | 1 |
| 14 | Primary spi nal melanoma显示文摘 | Larson Ⅲ T C Houser O W Onofrio B M | 1987 | Neurosurg1987，66，1： | 1 |
| 15 | Elective partial nephrectomy in patients with clinical Tlb renal tumors is associated with improved overall survival 显示文摘 | Weight C J Larson BT Gao T | 2010 | Urology2010，76，3： | 1 |
| 16 | The use of permanent interstitial temperature self-regulating rods for the ablation of prostate cancer 显示文摘 | Tucker RD Huidobro C Larson T | 2000 | J Endourol2000，14，6： | 1 |
| 17 | Tungsten segregation in α2+γ titanium aluminides显示文摘 | LIU C T MILLER M K | 1997 | Intermetallics1997，5，7： | 1 |
| 18 | Tungsten segregation in α2 + γ titanium aluminides显示文摘 | LIU C T MILLER M K | 1997 | Intermetallics1997，5，7： | 1 |
| 19 | Diagnosing groups : The pooling, management, and im- pact of shared and unshared case information in team - based medical decision making 显示文摘 | Larson J R Christensen C Franz T M Abbott A S | 1998 | Journal of Personal- ity & Social Psychology1998，，75： | 1 |
| 20 | Elective partial nephrectomy in patients with clinical T1b renal tumors is associated with improved overall survival显示文摘 | Weight C J Larson B T Gao T | 2010 | Urology2010，76，3： | 1 |
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