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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 3 | Pollen-medi- ated gene flow from Kentucky bluegrass under cultivated field conditions显示文摘 | JOHNSON P G Larson S R Anderton A L | 2006 | Crop Science2006，46，5： | 1 |
| 4 | Efficacy and safety of gemtuzumab ozogamicin in patients with CD33positive acute myeloid leukemia in first relapse显示文摘 | Sievers E L Larson R A Stadtmauer E A | 2001 | J Clin Oncol2001，，： | 1 |
| 5 | Use of gas chromatography - ion trap tandem mass spectrometry for the detection and characterization of microorganism in complex samples显示文摘 | Larson L Saraf A | 1997 | Molecular Biotechnology1997，7，3： | 1 |
| 6 | Reli- ability and validity of the 12 - minute distance walk in pa- tients with chronic obstructive pulmonary disease显示文摘 | LARSON J L COVEY M K VITALO C A | 1996 | Nurs Res1996，45，4： | 1 |
| 7 | A conserved domain in the coronavirus membrane protein tail is important for virus assembly 显示文摘 | Arudt A L Larson B J Hogue B G | 2010 | J Virol2010，84，11： | 1 |
| 8 | Adult stem eells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential 显示文摘 | PEISTER A MELLAD J A LARSON B L | 2004 | Blood2004，103，5： | 1 |
| 9 | Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches 显示文摘 | Li C Garrett-Beal L Larson D Wynshaw-Boris A Deng CX | 2001 | Genesis2001，30，1： | 1 |
| 10 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 11 | Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential显示文摘 | Peister A Melad J A Larson B L | 2004 | Blood2004，103，5： | 1 |
| 12 | Adult stem cells from bone marrow(MSCs) isolated from different strains of inbred mice vary in surface epitopes,rates of proliferation,and differentiation potential显示文摘 | Peister A Mellad J A Larson B L | 2004 | Blood2004，103，： | 1 |
| 13 | A conserved do-main in the coronavirus membrane protein tail is im -portant for virus assembly显示文摘 | Arndt A L Larson B J Hogue B G | 2010 | J Virol2010，84，11： | 1 |
| 14 | Repurposing CRISPR as an RNA-guided platform for seguence- specific control of gene expression显示文摘 | Qi L S Larson M H Gilbert L A | 2013 | Cell2013，152，5： | 1 |
| 15 | Final report of the efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first recurrence显示文摘 | Larson R A Sievers E L Stadtmauer E A | 2005 | Cancer2005，104，7： | 1 |
| 16 | Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of pwliferation, and differentiation potential 显示文摘 | Peister A Mellad J A Larson B L | 2004 | Blood2004，103，： | 1 |
| 17 | Apparatus dependence of normal brain tissue dose in stereotactic radiosurgery for multiple brain metastases显示文摘 | Ma L Petti P Wang B Descovich M Chuang C Barani IJ Kunwar S Shrieve DC Sahgal A Larson DA | 2011 | 中国神经肿瘤杂志2011，9，1： | 1 |
| 18 | Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes,rates of proliferation,and differentiation potential显示文摘 | Peister A Mellad J A Larson B L | 2004 | Blood2004，103，： | 1 |
| 19 | CRISPR-me- diated modular RNA-guided regulation of transcription in eukaryotes 显示文摘 | Gilbert L A Larson M H Morsut L | 2013 | Cell2013，154，2： | 1 |
| 20 | Therapist burnout: Perspectives on a critical issue 显示文摘 | Larson C C Gilbertson D L Powell J A | 1978 | Social Casework1978，，59： | 1 |
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