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| 1 | Trypanosoma rangeli:growth in mammalian cells in vitro and action of a repositioned drug(17-AAG)and a natural extract(Artemisia sp.essential oil)显示文摘Trypanosoma rangeli and T.cruzi are both parasitic unicellular species that infect humans.Unlike T.cruzi,the causative agent of Chagas disease,T.rangeli is an infective and non-pathogenic parasite for humans,but pathogenic for vectors from the Rhodnius genus.Because both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of T.rangeli in mammalian cells,we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on it.We found that T.rangeli exhibits a cycle of infection in Vero cells similar to that for T.cruzi and that the repurposed drug,17-AAG,and the natural extract Artemisia sp.essential oil produce a toxic effect on epimastigotes showing a trypanocidal action from the fifth day of culture.Both treatments also affected the infection of trypomastigotes and reduced the capacity of replication of amastigotes of T.rangeli.Since T.cruzi/T.rangeli coinfection cases have been reported,the finding of drugs with potential activity against both species could be significant in the future.Furthermore,studies of susceptibility of both species to drugs could also help to know the different mechanisms of pathogenicity in humans displayed by T.cruzi that are absent in T.rangeli. | Ana Laura CIMADOR Emeli Luciana GALANTE Lucila Ibel MUNOZ Patricia Silvia ROMANO Antonella Denisse LOSINNO Maria Cristina VANRELL | 2019 | BIOCELL2019，43，1： | 1 |
| 2 | Three facets of visual and verbal learners: Cognitive ability, cognitive style, and learning preference显示文摘 | Richard EM Laura JM | 2003 | Journal of Educational Psychology2003，95，4： | 1 |
| 3 | Tonometry as a predictor of inadequate splanchnic perfusion in an intra-abdominal hypertension animal model显示文摘 | Laura Correa-Martín Gregorio Castellanos Mónica García-Lindo Idoia Díaz-Güemes Francisco M. Sánchez-Margallo | 2013 | Journal of Surgical Research2013，，： | 1 |
| 4 | Guidelines for the design and analysis of studies on NSCLP in humans 显示文摘 | Laura EM Terri HB Andrew CL | 2002 | Cleft Palate Craniofac J2002，39，1： | 1 |
| 5 | 通过生化和蛋白组学分析探究应激标记显示文摘随着全球畜牧业发展和国际贸易自由化、规范化进程加快,动物福利越来越受到关注,故客观评估动物的福利水平至关重要。然而,目前的研究大多局限于基于动物表型以检测动物的福利水平,而评估动物福利水平的实验室生物标记信息很少,本文对不同饲养密度下母猪的应激进行了生化与蛋白组学分析,以期获得一套客观且易于检测的实验室参数用于动物福利的评估。 | 李岑岑 Anna MarcoRamell Laura Arroyo Raquel Pea Raquel Pato Yolanda Saco Lorenzo Fraile Em–ke Bendixen Anna Bassols | 2017 | 猪业科学2017，34，2： | 0 |
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