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| 1 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy显示文摘 | Vincenzo P Isabella M Eloisa A Barbel LS Laura V Monika A | 1998 | Am Heart Assoc1998，97，10： | 1 |
| 4 | A review of the acoustic-emission monitoring of wire rope显示文摘 | Casey N F Laura P A A | 1997 | Ocean Engineering1997，24，10： | 1 |
| 5 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 6 | A note on forced vibration of a clamped rectangular plate显示文摘 | Laura P A A Duran R | 1985 | J of Sound and Vibration1985，42，1： | 1 |
| 7 | On the dynamic behaviour of structural elements carrying elastically mounted,concentrated masses显示文摘 | Laura P A A Susemihl E A Pombo J L | 1977 | Applied Acoustics1977，10，2： | 1 |
| 8 | Considerations in the Statistical Analysis of Hemodialysis Patient Survival显示文摘 | Christos A Chung C Laura P | 2009 | J Am Soc Nephrol2009，20，9： | 1 |
| 9 | Effective primary isolation of wild-type Canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes显示文摘 | John A Lednicky Thomas P Meehan Michael J Kinsel Jean Dubach Laura L Hungerford Nicolene A Sarich Kelley E Witecki Michael D Braid Casandra Pedrak Christiane M Houde | 2004 | Journal of Virological Methods2004，，2： | 1 |
| 10 | Angiotensin H induces leukocyte endothelial cell interactions in vivo via AT1 and AT2 receptor medi- ated P-selectin upregulation显示文摘 | Laura P Paul K Angeles A | 2000 | Circulation2000，102，17： | 1 |
| 11 | A review of the acoustic emission monitoring of wire rope显示文摘 | CASEY N F LAURA P A A | | 0，，10： | 1 |
| 12 | The relationship between parental involvement as social capital and college enrollment:an exami- nation of racial/ethnic group differences 显示文摘 | LAURA W P MARVIN A T | 2005 | The journal of higher education2005，76，5： | 1 |
| 13 | Measuring core stability显示文摘 | Wendell P Liemhn Ted A Baumgartner Laura H Gagnon | 2005 | J Strength CondRes2005，19，3： | 1 |
| 14 | Fundamental frequency of vibration of a Timoshenko beam of non uniform thickness 显示文摘 | GUTIERREZ R H LAURA P A A ROSSI R E | 1991 | Journal of Sound and Vibration1991，145，： | 1 |
| 15 | Approximate studyof the free vibrations of a cantilever anisotropic plate carryinga concentrated mass显示文摘 | Ciancio P M Rossit C A Laura P A A | 2007 | Journal of Sound and Vibration2007，302，3： | 1 |
| 16 | Influence of sub-lethal antiox- idant doses, water potential and temperature on growth, sclero- tia, aflatoxins and aflD( = nor-1 ) expression by Aspergillus fla- vus RCP08108显示文摘 | Maria A P Laura C R Miriam E | 2012 | Microbiol Res2012，167，8： | 1 |
| 17 | Hot air treatment delays senescence and maintains quality of fresh-cut broccoli florets during refrigerated storage显示文摘 | LAURA L M CIVELLO P CHAVES A MARTINEZ G | 2009 | LWT - Food Science and Technology2009，42，6： | 1 |
| 18 | Natural frequencies of a Bernoulli beam carrying an elastically mounted concentrated mass显示文摘 | Larrondo H Avalos D Laura P A A | 1992 | Ocean Engineering1992，19，5： | 1 |
| 19 | Free vibrations of Timoshenko beams carrying elastically mounted,concentrated masses显示文摘 | Rossi R E Laura P A A Avalos D R | 1993 | Journal of Sound and Vibration1993，165，2： | 1 |
| 20 | Measuring core- stability显示文摘 | Wendell P L Ted A B Laura H G | 2005 | J Strength Condres2005，19，3： | 1 |
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