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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Gastric cancer:correlation between clinicopathological factors and survival of patients (Ⅲ)显示文摘 | Lazǎr D Tāban S Sporea I | | 0，，： | 1 |
| 3 | Immunohistochemical evaluation of the tumor neoangiogenesis as a prognostic factor for gastric cancers显示文摘 | Laz(a)r D T(a)ban S Raica M | 2008 | Rom J Morphol Embryol2008，49，2： | 1 |
| 4 | I dentification and pharmacological characterization of a nove human melanin concentrating hormone receptor,MCH-R2显示文摘 | Wang S Behan J O' Neill K Weig B Fried S Laz T | 2001 | J Biol Chem2001，276，34： | 1 |
| 5 | The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells:comparison with serum-stimulated 3T3 cells and identification of41 novel immediate-early genes显示文摘 | MOHN K I LAZ T M HSU J C | 1991 | Mol Cell Biol1991，11，1： | 1 |
| 6 | PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth显示文摘 | DIAMOND R H CRESSMAN D E LAZ T M | 1994 | Mol Cell Biol1994，14，6： | 1 |
| 7 | Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil显示文摘 | Luciana T Laz ra MS Wanke B | 2008 | Mem Inst Oswaldo Cruz2008，103，5： | 1 |
| 8 | Electrochemical deposi- tion and properties of polypyrrole显示文摘 | Migdalski J Laz T Lewenstam-A | 1999 | Anal Chim Acta1999，395，3： | 1 |
| 9 | The immediate-early growth re- sponse in regenerating liver and insulin-stimulated H-35 ceils : compar- ison with sreum-stimulated 3T3 cells and identification of 41 novel im- mediate-early gene显示文摘 | Mohn K L Laz T M Hsu J C | 1991 | Mol Cell Biol1991，11，1： | 1 |
| 10 | The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes显示文摘 | Mohn K L Laz T M I-Isu J C | 1991 | Mol Cell Biol1991，11，1： | 1 |
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