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| 1 | Clinical significance of lactate in acute cardiac patients显示文摘Lactate, as a metabolite of easy and quick assessment, has been studied over time in critically ill patients in order to evaluate its prognostic ability. The present review is focused on the prognostic role of lactate levels in acute cardiac patients(that is with acute coronary syndrome, cardiogenic shock, cardiac arrest, non including post cardiac surgery patients). In patients with STelevation myocardial infarction treated with mechanical revascularization, hyperlactatemia identified a subset of patients at higher risk for early death and in-hospital complications, being strictly related mainly to hemodynamic derangement. The prognostic impact of hyperlactatemia on mortality has been documented in patients with cardiogenic shock and in those with cardiac arrest even if there is no cut-off value of lactate to be associated with worse outcome or to guide resuscitation or hemodynamic management. Therapeutic hypothermia seems to affect per se lactate values which have been shown to progressively decrease during hypothermia. The mechanism(s) accounting for lactate levels during hypothemia seem to be multiple ranging from the metabolic effects of reduced temperatures to the hemodynamic effects of hypothermia(i.e., reduced need of vasopressor agents). Serial lactate measurements over time, or lactate clearance, have been reported to be clinically more reliable than lactate absolute value also in acute cardiac patients. Despite differences in study design, timing of lactate measurements and type of acute cardiac conditions(i.e., cardiogenic shock, cardiac arrest, refractory cardiac arrest), available evidence strongly suggests that higher lactate levels can be observed on admission in non-survivors and that higher lactate clearance is associated with better outcome. | Chiara Lazzeri Serafina Valente Marco Chiostri Gian Franco Gensini | 2015 | World Journal of Cardiology2015，7，8： | 10 |
| 2 | Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage显示文摘AIM: This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal antiinflammatory drugs (NSAIDs) in rats.METHODS: Male Sprague-Dawley rats were orally treated with indomethacin (100 μmol/kg), diclofenac (60 μmol/kg),piroxicam (150 μmol/kg) or ketoprofen (150 μmol/kg).Thirty minutes before NSAIDs, animals were orally treated with lansoprazole 18 or 90 μmol/kg. Four hours after the end of treatments, the following parameters were assessed: gastric mucosal PGE2, malondialdehyde (MDA), myeloperoxidase (MPO) or non-proteic sulfhydryl compounds (GSH) levels; reverse transcription-polymerase chain reaction (RT-PCR) of mucosal COX-2 mRNA; gastric acid secretion in pylorus-ligated animals; in vitro effects of lansoprazole (1-300 μmol/L) on the oxidation of low density lipoproteins (LDLs) induced by copper sulphate.RESULTS: All NSAIDs elicited mucosal necrotic lesions which were associated with neutrophil infiltration and reduction of PGE2 levels. Increments of MPO and MDA contents, as well as a decrease in GSH levels were detected in the gastric mucosa of indomethacin- or piroxicam-treated animals. Indomethacin enhanced mucosal cyclooxygenase-2 expression, while not affecting cyclooxygenase-1. At the oral dose of 18 μmol/kg lansoprazole partly counteracted diclofenac-induced mucosal damage, whereas at 90 μmol/kg it markedly prevented injuries evoked by all test NSAIDs. Lansoprazole at 90 μmol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression. However, both lansoprazole doses markedly inhibited acid secretion in pylorus-ligated rats. Lansoprazole concentration-dependently reduced the oxidation of LDLs in vitro.CONCLUSION: These results suggest that, besides the inhibition of acid secretion, lansoprazole protection against NSAID-induced gastric damage depends on a reduction in mucosal oxidative injury, which is also responsible for an increment of sulfhydryl radical bioavailability. It is also suggested that lansoprazole does not influence the downregulation of gastric prostaglandin production associated with NSAID treatment. | Corrado Blandizzi Matteo Fornai Rocchina Colucci Gianfranco Natale Valter Lubrano Cristina Vassalle Luca Antonioli Gloria Lazzeri Mario Del Tacca | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 3 | History and evolution of the use of oral mucosa for urethral reconstruction显示文摘We report here the history and evolution of the use of oral mucosa in reconstructive urethral surgery since it was first used for urethroplasty in 1894.Since that time,many authors have contributed to develop,improve and popularize the use of oral mucosa as a substitute material.Paediatric urologists should be considered pioneers on the use of oral mucosa as they used it to repair primary and failed hypospadias.The use of oral mucosa to repair penile and bulbar urethral strictures was described,for the first time,in 1993.Important evolutions in the technique for harvesting oral mucosa from the cheek were reported in 1996.Today,oral mucosa is considered the gold standard material for any type of anterior urethroplasty in a one-or two-stage repair due to its biological and structural characteristics that make it a highly versatile that is adaptable to any environment required by the reconstructive urethral surgery.As the future approaches,tissue engineering techniques will provide patients with new materials originating from the oral epithelial mucosal cells,which are cultured and expanded into a scaffold.However,the path to reach this ambitious objective is still long and many difficulties must be overcome along the way. | Guido Barbagli Sofia Balo Francesco Montorsi Salvatore Sansalone Massimo Lazzeri | 2017 | Asian Journal of Urology2017，4，2： | 6 |
| 4 | 肠道子宫内膜异位症诊断和治疗的新观点显示文摘子宫内膜异位症是一种主要影响育龄妇女的慢性疾病。部分肠道子宫内膜异位症患者可能是无症状的,除了不孕之外,有部分患者表现为各种各样的症状,如排便习惯改变(便秘或腹泻)、排便困难、痛经和性交痛等。迄今为止,对于疑似有肠道受累的子宫内膜异位症患者,尚无明确的评估指南。目前的检查手段包括经阴道或经直肠超声检查、核磁共振成像和气钡双重对比造影。不同的检查方法可提供更多的信息,包括是否存在病灶、病灶的位置和累及的范围等,确保患者充分了解病情,同时也可对术前计划进行优化。如需手术治疗,应由经验丰富的医生在有多学科护理条件的中心进行手术。治疗应根据患者的症状和意愿进行调整,目的是尽可能切除所有病灶的同时保留器官的功能。本综述将讨论肠道子宫内膜异位症诊断和处理的最新观点。 | 梁炎春 韦雅婧 杨如玉 姚书忠(译/审校) Nassir Habib Gabriele Centini Lucia Lazzeri Nicola Amoruso Lionel El Khoury Errico Zupi Karolina Afors | 2020 | 国际妇产科学杂志2020，47，6： | 3 |
| 5 | Transformation of wheat with high molecular weight subunit genes results in improved functional properties显示文摘 | Barro F Rooke L Bekes F Gras P Tatham A S Fido R Lazzeri P A Shewry P R Barcelo P | 1997 | Nat Biotechnol1997，15，12： | 2 |
| 6 | Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction显示文摘In population-based studies,including diabetic and nondiabetic cohorts,glycated hemoglobin A1c(HbA1c) has been reported as an independent predictor of allcause and cardiovascular disease mortality.Data on the prognostic role of HbA1c in patients with acute myocardial infarction(MI) are not univocal since they stem from studies which mainly differ in patients' selection criteria,therapy(thrombolysis vs mechanical revascularization) and number consistency.The present review is focused on available evidence on the prognostic significance of HbA1c measured in the acute phase in patients with ST-elevation myocardial infarction(STEMI) submitted to primary percutaneous coronary intervention(PCI).We furthermore highlighted the role of HbA1c as a screening tool for glucose intolerance in patients with STEMI.According to available evidence,in contemporary cohorts of STEMI patients submitted to mechanical revascularization,HbA1c does not seem to be associated with short and long term mortality rates.However,HbA1c may represent a screening tool for glucose intolerance from the early phase on in STEMI patients.On a pragmatic ground,an HbA1c testhas several advantages over fasting plasma glucose or an oral glucose tolerance test in an acute setting.The test can be performed in the non-fasting state and reflects average glucose concentration over the preceding 2-3 mo.We therefore proposed an algorithm based on pragmatic grounds which could be applied in STEMI patients without known diabetes in order to detect glucose intolerance abnormalities from the early phase.The main advantage of this algorithm is that it may help in tailoring the follow-up program,by helping in identifying patients at risk for the development of glucose intolerance after MI.Further validation of this algorithm in prospective studies may be required in the contemporary STEMI population to resolve some of these uncertainties around HbA1c screening cutoff points. | Chiara Lazzeri Serafina Valente Marco Chiostri Maria Grazia D'Alfonso Gian Franco Gensini | 2014 | World Journal of Cardiology2014，6，4： | 2 |
| 7 | Hemodynamic management in brain dead donors显示文摘Donor management is the key in the complex donation process,since up to 20%of organs of brain death donors(DBD)are lost due to hemodynamic instability.This challenge is made more difficult due to the lack of strong recommendations on therapies for hemodynamic management in DBDs and more importantly to the epidemiologic changes in these donors who are becoming older and with more comorbidities(marginal donors).In the present manuscript we aimed at summarizing the available evidence on therapeutic strategies for hemodynamic management(focusing on vasoactive drugs)and monitoring(therapeutic goals).Evidence on management in elderly DBDs is also summarized.Donor management continues critical care but with different and specific therapeutic goals since the number of donor goals met is related to the number of organs retrieved and transplanted.Careful monitoring of selected parameters(possibly including serial echocardiography)is the clinical tool able to guarantee the achievement and maintaining of therapeutic goals.Despide worldwide differences,norepinephrine is the vasoactive of choice in most countries but,whenever higher doses(>0.2 mcg/kg/min)are needed,a second vasoactive drug(vasopressin)is advisable.Hormonal therapy(desmopressin,corticosteroid and thyroid hormone)are suggested in all DBDs independently of hemodynamic instability.In the single patient,therapeutic regimen(imprimis vasoactive drugs)should be chosen also according to the potential organs retrievable(i.e.heart vs liver and kidneys). | Chiara Lazzeri Manuela Bonizzoli Cristiana Guetti Giorgio Enzo Fulceri Adriano Peris | 2021 | World Journal of Transplantation2021，11，10： | 2 |
| 8 | Human CD8^+CD25^+ thymocytes share phenotypic and functional features with CD4^+CD25^+ regulatory thymocytes显示文摘 | Cosmi L Liotta F Lazzeri E | 2003 | Blood2003，102，12： | 1 |
| 9 | Contrast - induced nephropathy in urgent coronary interventions 显示文摘 | Valente S Lazzeri C Giglioli C | 2006 | 7:737 -7412006，7，： | 1 |
| 10 | Postprocedural hyperglycemia in ST elevation myocardial infarction submitted to percutaneous coronary intervention:a prognostic indicator and a marker of metabolic derangement显示文摘 | Lazzeri C Chiostri M Sori a | 2010 | J Cardiovasc Med(Hagerstown)2010，，11： | 1 |
| 11 | Correlates of acute insulin resistance in the early phase of non-diabetic ST-elevation myocardial infarction显示文摘 | Lazzeri C Valente S Chiostri M | 2011 | Diab Vase Dis Res2011，8，1： | 1 |
| 12 | Prefabricated neck expand- ed skin flap with the superficial temporal vessels for facial resurfacing显示文摘 | Lazzeri D Su W Qian Y | 2013 | J Reconstr Microsurg2013，29，4： | 1 |
| 13 | Uric acid in the early risk strat- ification of ST - elevation myocardial infarction 显示文摘 | Lazzeri C Valente S Chiostri M | 2012 | Intern Emerg Med2012，7，1： | 1 |
| 14 | Field evaluation and agronomic performance of transgenic wheat显示文摘 | F. Barro P. Barceló P. Lazzeri P. Shewry A. Martín J. Ballesteros | 2002 | Theoretical and Applied Genetics (-)2002，，6： | 1 |
| 15 | Cardiovascular and renal effects of low dose brain natriuretic peptide infusion in man显示文摘 | LAVILLA G FRONZAROLI C LAZZERI C | 1994 | J Clin Endocrinol Metab1994，78，5： | 1 |
| 16 | Urodynamic assessment during intravesical infusion of capsaicin for the treatment of refractory detrusor hyperreflexia显示文摘 | Spinelli M Beneforti P | 1999 | Spinal Cord1999，37，： | 1 |
| 17 | Expression of IP-10/ CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/ CXCL10 in the serum of patients with recent-unset Graves' disease 显示文摘 | Romagnani P Rotondi M Lazzeri E | 2002 | Am J Pathol2002，161，： | 1 |
| 18 | Troponin I in the intensive care unit setting:from the heart显示文摘 | Lazzeri C Bonizzoli M Cianchi G | | 0，，01： | 1 |
| 19 | Uric acid in the acute phase of ST elevation myocardial in- farction submitted to primary PCI: its prognostic role and relation with inflammatory markers: a single center experience显示文摘 | Lazzeri C | 2010 | Int J Cardiol2010，138，2： | 1 |
| 20 | uric aciu in me acute phase of ST elevation myocardial infarction submitted to primary PCI: its prognostic role and relation with inflammatory markers: a single center experience 显示文摘 | Lazzeri C Yalente S Chiostri M | 2010 | Int J Cardiol2010，138，2： | 1 |
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