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| 1 | Recent advances in the management of rectal cancer: No surgery, minimal surgery or minimally invasive surgery显示文摘Over the last decade,with the acceptance of the need for improvements in the outcome of patients affected with rectal cancer,there has been a significant increase in the literature regarding treatment options available to patients affected by this disease.That treatment related decisions should be made at a high volume multidisciplinary tumor board,after pre-operative rectal magnetic resonance imaging and the importance of total mesorectal excision(TME)are accepted standard of care.More controversial is the emerging role for watchful waiting rather than radical surgery in complete pathologic responders,which may be appropriate in 20%of patients.Patients with early T1 rectal cancers and favorable pathologic features can be cured with local excision only,with transanal minimal invasive surgery(TAMIS)because of its versatility and almost universal availability of the necessary equipment and skillset in the average laparoscopic surgeon,emerging as the leading option.Recent trials have raised concerns about the oncologic outcomes of the standard'top-down'TME hence transanal TME(Ta TME'bottom-up')approach has gained popularity as an alternative.The challenges are many,with a dearth of evidence of the oncologic superiority in the long-term for any given option.However,this review highlights recent advances in the role of chemoradiation only for complete pathologic responders,TAMIS for highly selected early rectal cancer patients and Ta TME as options to improve cure rates whilst maintaining quality of life in these patients,while we await the results of further definitive trials being currently conducted. | Joseph M Plummer Pierre-Anthony Leake Matthew R Albert | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 6 |
| 2 | Rational Sirna Design for RNA Interference显示文摘 | ANGELA R LEAKE D BOESE Q | | 0，，03： | 1 |
| 3 | Zinc accumulation by Thlaspi caerulescens from soils with different Zn availability: a pot study 显示文摘 | Whiting S N Leake J R McGrath S P | 2001 | Plant Soil2001，236，： | 1 |
| 4 | Assessment of Zn mobilization in the rhizosphere of Thlaspi caerulescens by bioassay with nonaccumulator plants and soil extraction 显示文摘 | Whiting S N Leake J R McGrath S P | 2001 | Plant and Soil2001，237，： | 1 |
| 5 | Changes in soil microbial biomass and microbial activities in response to 7 years simulated pollutant nitrogen deposition on a heathland and two grasslands 显示文摘 | Johnson D Leake J R Lee J A | 1998 | Environmental Pollution1998，103，23： | 1 |
| 6 | Mycorrhizal ac- quisition of inorganic phosphorus by the green-leaved ter- restrial orchid Goodyera repens 显示文摘 | Cameron D D Johnson I Leake J R | 2007 | Annals of Botany2007，99，： | 1 |
| 7 | The behaviolal mede] h)r vulnerable populations: application to medical care use and outcomes for homeless people显示文摘 | Gelberg L Andersen R M Leake B 1) | 2000 | Health Serv Res2000，34，6： | 1 |
| 8 | Immunohistochemical detection of steroid receptors in breast cancer:a working protocol显示文摘 | Leake R Barnes D Pinder S | 2000 | J Clin Pathol2000，53，8： | 1 |
| 9 | The orphan nuclear receptor HNF4alpha determines PXR-and CAR-mediated xenobiotic induction of CYP3A4显示文摘 | Tirona R G Lee W Leake B F | 2003 | Nat Med2003，9，2： | 1 |
| 10 | A systematic review of the accuracy and indications for diagnostic laparoseopy prior to cura- tive-intent resection of gastric cancer 显示文摘 | Leake PA Cardoso R Seevaratnam R | 2012 | Gastric Cancer2012，15，1： | 1 |
| 11 | Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein 显示文摘 | Kim R B Wandel C Leake B | 1999 | Pharm Res1999，16，3： | 1 |
| 12 | Plant communities affect arbuscular mycorrhizal fungal diversity and community composition in grassland microcosms 显示文摘 | JOHNSON D VANDENKOORNHUYSE P J LEAKE J R | 2003 | New phytologist2003，161，： | 1 |
| 13 | Biological weatheringand the long-term carbon cycle: Integrating mycorrhizalevolution and function into the current paradigm显示文摘 | TAYLOR L L LEAKE J R QUIRK J | 2009 | Geobiology2009，7，2： | 1 |
| 14 | Why do symptomatic patients delay obtaining care for tuberculosis? 显示文摘 | Asch S Leake B Anderson R | 1998 | American journal of respiratory and critical care medicine1998，157，4： | 1 |
| 15 | Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins:effects of antioxident vitamins on oxidized LDL-induced increase in cystin transport and glutathione显示文摘 | Sato H Leake D S | 1998 | Arterioscler Thromb Vasc Biol1998，18，10： | 1 |
| 16 | Nomenclature of amphiboles:report of the subcommittee on amphiboles of the International Mineralogical Association,commission on new minerals and mineral names显示文摘 | Woolley A R Arps C E S | 1997 | The Canadian Mineralogist1997，35，： | 1 |
| 17 | Suprachiasmatic nu- cleus organization 显示文摘 | Moore R Y Speh J C Leak R K | 2002 | Cell and Tissue Research2002，309，1： | 1 |
| 18 | Production of transforming growth factor alpha by normal and polycystic ovaries 显示文摘 | Carr L Leake R | 1995 | J Clin Endocrinol Metab1995，80，7： | 1 |
| 19 | Nomenclature of amphiboles:Report of the subcommittee on amphiboles of the International Mineralogical Association,Commission on New Minerals and Mineral Names显示文摘 | Leake B E Woolley A R Arps C E S | 1997 | Mineralogical Magazine1997，61，： | 1 |
| 20 | Practical approaches to low density lipoprotein oxidation: whys, wherefores and pitfalls 显示文摘 | Rice-Evans C Leake D Bruckdorfer K R | 1996 | Free Radic Res1996，25，4： | 1 |
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