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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Bemisia tabaci Biotype Dynamics and Resistance to Insecticides in Israel During the Years 2008-2010显示文摘The sweetpotato whitefly Bemisia tabaci(Hemiptera:Aleyrodidae)is an extremely polyphagous insect pest that causes significant crop losses in Israel and worldwide.B.tabaci is a species complex of which the B and Q biotypes are the most widespread and damaging worldwide.The change in biotype composition and resistance to insecticide in Israel was monitored during the years 2008-2010 to identify patterns in population dynamics that can be correlated with resistance outbreaks.The results show that B biotype populations dominate crops grown in open fields,while Q biotype populations gradually dominate crops grown in protected conditions such as greenhouses and nethouses,where resistance outbreaks usually develop after several insecticide applications.While in previous years,Q biotype populations were widely detected in many regions in Israel,significant domination of the B biotype across populations collected was observed during the year 2010,indicating the instability of the B.tabaci population from one year to another.Reasons for the changing dynamics and the shift in the relative abundance of B.tabaci biotype,and their resistance status,are discussed. | Svetlana Kontsedalov Fauzi Abu-Moch Galina Lebedev Henryk Czosnek A Rami Horowitz Murad Ghanim | 2012 | Journal of Integrative Agriculture2012，11，2： | 2 |
| 3 | Renal artery denervation suppresses intractable ventricular arrhythmia in patients with left heart thrombosis显示文摘Transcutaneous renal artery denervation (RND) has beeninitially developed for destruction of efferent nerve fireswith luminal delivery of radiofrequency or ultrasonic energyaiming blood pressure reduction in patients with refractoryhypertension. However, other positive results of RNDwere described afterwards, and they include suppression ofatrial fibrillation and ventricular tachycardia (VT) storm. | Marianna A Vander Petr A Fedotov Tamara A Lyubimtseva Maria A Bortsova Maria Yu Simikova Dmitry S Lebedev Evgeny N Mikhaylov | 2017 | Journal of Geriatric Cardiology2017，14，9： | 2 |
| 4 | Transesterification of rapeseed oil under fiow conditions catalyzed by basic solids: M - AI(La) -O (M =Sr, Ba), M-Mg-O (M=Y, La) 显示文摘 | SHERSTYUK O V IVANOVA A S LEBEDEV M Y | 2012 | Appl Catal A- Gen2012，，： | 1 |
| 5 | Biochemical and structural studies of a L-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii显示文摘 | Rye C A Isupov M N Lebedev A A | 2009 | Extremophiles2009，13，1： | 1 |
| 6 | Chronic asympto-matic hyperuricemia as a marker of atherogenic risk in children 显示文摘 | Maliavskaia S I Lebedev A V Temovskaia V A | 2007 | Kardiologiia2007，47，3： | 1 |
| 7 | The phylogeny and systematics of the endemic Ethiopian Lophuromys flavopunctatus species complex based upon random amplified polymorphic DNA (RAPD) analysis显示文摘 | Lavrenchenko L A Potapov S G Lebedev V S | 2001 | Bioch Syst Ecol2001，29，11： | 1 |
| 8 | Simultaneous Reaction of Diorganodiaminosilanes and Diorganodiehlorosilanes with Diphenylsilanediol显示文摘 | Lebedev E P Fedorov A D | 1978 | J Gen Chem USSR (Engl Transl)1978，，48： | 1 |
| 9 | Optical absorption spectroscopy of synthetic tourmalines 显示文摘 | TARAN M N LEBEDEV A S PLATONOV A N | 1993 | Phys Chem Miner1993，20，3： | 1 |
| 10 | Cold Crucible Inductive Melting Technology Application to Vitrification and Ceramization of High Level and Actinide Wastes显示文摘 | Stefanovsky S V Lebedev V V Ptashkin A G | 2010 | Advances in Science and Technology2010，73，： | 1 |
| 11 | Deep level in silicon carbide显示文摘 | Lebedev A A | | 0，，03： | 1 |
| 12 | Plasma formation and implosion structure in wire array Z pinches显示文摘 | Chittenden J P LebedevS V Bell A R | 1999 | PhysRev Lett1999，83，： | 1 |
| 13 | High-efficiency mist eliminators显示文摘 | Lebedev Y N Zil'berberg I A Lozhkin Y P | 2002 | Chemistry and Technology of Fuels and Oils2002，38，1： | 1 |
| 14 | Learning to control a brain-machine interface for reaching and grasping by primates显示文摘 | Carmena J M Lebedev M A Crist R E | 2003 | PLoS Biology2003，1，2： | 1 |
| 15 | Crossed products by endomorphisms and reduction of relations in relative Cuntz-Pimsner algebras显示文摘 | Kwasniewski B K Lebedev A V | 2013 | J Func Anal2013，264，： | 1 |
| 16 | GC- MS comparison of the behavior of chlorine and sodium hy- pochlorite towards organic compounds dissolved in water 显示文摘 | Lebedev A T Shaydullina G M Sinikova N A | 2004 | Water Res2004，38，17： | 1 |
| 17 | OXYS rats as a model of senile cataract显示文摘 | KOLOSOVA N G LEBEDEV P A AIDAGULOVA S V | 2003 | Bull Exp Biol Med2003，136，41： | 1 |
| 18 | Biochemical and structural studies of a haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii显示文摘 | Rye C Isupov M Lebedev A | | 0，，： | 1 |
| 19 | Brain - machine interface : pase,present and future 显示文摘 | Lebedev M A Nicolelis M A L | 2006 | Trends in Neurosciences2006，29，9： | 1 |
| 20 | GC-MS comparison of the behavior of chlorine and sodium hypochlorite towards organic compounds dissolved in water显示文摘 | Albert T Lebedev Gulnara M Shaydullina Nstalia A Sinikova | 2004 | Water Research2004，38，17： | 1 |
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