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| 1 | Effect of glutarnate on inflammatory responses of intestine and brain after focal cerebral ischemia显示文摘AIM: To study the modulation of glutamate on post-ischemic intestinal and cerebral inflammatory responses in a ischemic and excitotoxic rat model.METHODS: Adult male rats were subjected to bilateral carotid artery occlusion for 15 min and injection of monosodium glutamate intraperitoneally, to decapitate them at selected time points. Tumor necrosis factor alpha (TNF-α) level and nuclear factor kappa B (NF-κB) activity were determined by enzyme-linked immunosorbant assay (ELISA) and electrophoretic mobility shift assay (EMSA), respectively.Hemodynamic parameters were monitored continuously during the whole process of cerebral ischemia and reperfusion.RESULTS: Monosodium glutamate (MSG) treated rats displayed statistically significant high levels of TNF-α in cerebral and intestinal tissuess within the first 6 h of ischemia. The rats with cerebral ischemia showed a minor decrease of TNF-α production in cerebral and intestinal tissuess. The rats with cerebral ischemia and treated with MSG displayed statistically significant low levels of TNF-α in cerebral and intestinal tissues. These results correlated significantly with NF-κB production calculated at the same intervals. During experiment, the mean blood pressure and heart rates in all groups were stable.CONCLUSION: Glutamate is involved in the mechanism of intestinal and cerebral inflammation responses. The effects of glutamate on cerebral and intestinal inflammatory responses after ischemia are up-regulated at the transcriptional level,through the NF-κB signal transduction pathway. | LeiXu JieSun RanLu QingJi Jian-GuoXu | 2005 | World Journal of Gastroenterology2005，11，5： | 15 |
| 2 | Relationship between abnormality of FHIT gene and EBV infection in gastric cancer显示文摘AIM: To examine the aberrant expression of fragile histidine triad (FHIT) gene and protein in gastric cancer, and to evaluate the role of FHIT gene and the relationship between FHIT gene and EBV infection in gastric carcinogenesis.METHODS: FHIT transcripts were detected by nested RT PCR in 30 cases of gastric cancer and their products were sequenced. FHIT protein was detected by Western blot.EBV infection was detected by PCR method in 50 cases of gastric cancer.RESULTS: The wild type transcripts were detected in all 30 matched normal tissues of gastric cancer. Aberrant transcripts were found in 11/30 (36.7%) gastric cancerous tissues. Sequencing analysis of the aberrant fragments found an RT-PCR product missing exons 5-7 in one case of gastric cancer, and another product missing exons 4-7. Four of ten (40.0%) cases of primary gastric cancer showed absent or decreased expression of FHIT protein as compared with their matched normal tissues. EBV was detected in 5/50 (10%) gastric cancers, among which 4/5 (80%) had aberrant transcripts of FHIT gene. CONCLUSION: Loss of FHIT gene or FHIT protein p1ays an important role in carcinogenesis, development and progression of gastric cancer. EBV infection might influence carcinogenesis of gastric cancer by inducing the abnormality of FHIT gene. | Yu-PingXiao Cheng-BoHan Xiao-YunMao Jin-YiLi LeiXu Chang-ShanRen YanXin | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 3 | Influence of Aging Time on the Properties of Precursors of CuO/ZnO Catalysts for Methanol Synthesis显示文摘The aging process of pure copper precursors and copper-zinc binary precursors were studied by XRD, TG-DTG and TPR techniques. The catalytic activity and stability of CuO/ZnO were tested using fixed-bed flow reactor, and the physical properties of the catalysts and Cu species were characterized with N2 adsorption and N2O passivation method, respectively. For the Cu-Zn binary system prepared at the precipitating condition of pH=8.0 and temperature=80 ℃, the initial phase was a mixture of copper nitrate hydroxide Cu2(NO3)(OH)3, georgeite and hydrozincite Zn5(CO3)2(OH)6. By increasing the duration of its aging time, the phase of Cu2(NO3)(OH)2 first transited to georgeite, and then interdiffused into Zn5(CO3)2(OH)6 and resulted in two new phases: rosasite (Cu,Zn)2CO3(OH)2 and aurichalcite (Zn,Cu)5(CO3)2(OH)6. The former phase was much easier to be formed than the latter one,while the latter phase was more responsible for the activity of methanol synthesis than the former one. It is found that the composition and structure of the precursors altered obviously after the colour transition point. The experimental results showed that methanol synthesis is a structure-sensitive catalytic reaction. | DerenFang ZhongminLiu ShuangheMeng LigangWang LeiXu HuaWang | 2005 | Journal of Natural Gas Chemistry2005，14，2： | 5 |
| 4 | NegativeinterferenceinserumHBsAgELISAfromrheumatoidfactors显示文摘 | LeiXu ZhenYu WenFan eta1 | 2013 | PLoSOne2013，8，80： | 1 |
| 5 | Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures显示文摘 | HongGuo ZhongshuTang YiYu LeiXu GuozhangJin JiaweiZhou | 2002 | European Journal of Neuroscience2002，，10： | 1 |
| 6 | Expression of metastasis-related genes in human epithelial ovarian tumors 显示文摘 | Herrera A Leixu Corazon D | 2002 | Int J Oncol2002，20，： | 1 |
| 7 | A new curv detection method: randomized Hough transform (RHT)显示文摘 | LeiXu Erkki Oja Pekka Kultanen | 1990 | Pattern Recognition Letters1990，11，1： | 1 |
| 8 | Spatial-Temporal Variation Characteristics and Cause Analysis of Water Quality in Yinma River Basin显示文摘In order to comprehensively understand the water quality in Yinma River Basin,and to analyze the spatial-temporal variation characteristics of water quality over the years and the causes of water pollution,15 sections were selected in the Yinma River Basin.Based on the water quality monitoring data in the past decade,7 evaluation indexes including dissolved oxygen(DO),5-day biochemical oxygen demand(BOD_(5)),permanganate index(COD_(MN)),chemical oxygen demand(COD),ammonia nitrogen(NH_(4)-N),total phosphorus(TP)and total nitrogen(TN)were determined,according to the Environmental Quality Standard for Surface Water(GB3838-2002)and the historical monitoring data of rivers.The water quality of 15 sections in Yinma River Basin was comprehensively evaluated,and the water quality categories and the evolution of river water quality were analyzed.The pollution sources of Yinma River Basin were analyzed,and the constructive countermeasures were put forward according to the conclusions. | Xiaolai WU Jing WANG Shukun JIANG LeiXU Xiangzhe MENG | 2022 | Asian Agricultural Research2022，14，4： | 0 |
| 9 | Reduced-Order Observer-Based LQR Controller Design for Rotary Inverted Pendulum显示文摘The Rotary Inverted Pendulum(RIP)is a widely used underactuated mechanical system in various applications such as bipedal robots and skyscraper stabilization where attitude control presents a significant challenge.Despite the implementation of various control strategies to maintain equilibrium,optimally tuning control gains to effectively mitigate uncertain nonlinearities in system dynamics remains elusive.Existing methods frequently rely on extensive experimental data or the designer’s expertise,presenting a notable drawback.This paper proposes a novel tracking control approach for RIP,utilizing a Linear Quadratic Regulator(LQR)in combination with a reduced-order observer.Initially,the RIP system is mathematically modeled using the Newton-Euler-Lagrange method.Subsequently,a composite controller is devised that integrates an LQR for generating nominal control signals and a reduced-order observer for reconstructing unmeasured states.This approach enhances the controller’s robustness by eliminating differential terms from the observer,thereby attenuating unknown disturbances.Thorough numerical simulations and experimental evaluations demonstrate the system’s capability to maintain balance below50Hz and achieve precise tracking below1.4 rad,validating the effectiveness of the proposed control scheme. | Guogang Gao LeiXu Tianpeng Huang Xuliang Zhao Lihua Huang | 2024 | Computer Modeling in Engineering & Sciences2024，140，7： | 0 |
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