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| 1 | 显示文摘 | Leimer M Kurtaran A Smith-Jones P | 1998 | J Nucl Med1998，39，12： | 1 |
| 2 | Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes显示文摘 | Anzuetol A Leimer Kesten S | 2009 | International Journal of COPD2009，4，： | 1 |
| 3 | Value of peptide receptor scintigraphy using 1231 - vasoactive intestinal peptide and 111 In - DTPA -D- Phel -octreotide in 194 carcinoid patients: Vienna University Experience, 1993 to 1998 显示文摘 | Raderer M Kurtaran A Leimer M | 2000 | J Clin Oncol2000，18，6： | 1 |
| 4 | Comparison of meth- ods for the determination of ochratoxin A in wine显示文摘 | Leimer A Zollener P Paolillo A | 2002 | Analyti- cal Chimica Acta2002，453，： | 1 |
| 5 | Value of peptide receptor scintigraphy using (123) I-vasoactive intestinal peptide and ( 111 ) In-DTPA-D-Phel-octreotide in 194 carcinoid patients: Vienna University Experience,1993 to 1998显示文摘 | Raderer M Kurtaran A Leimer M | 2000 | J Clin Oncol2000，18，6： | 1 |
| 6 | Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease 显示文摘 | Steiner H Capell A Leimer U | 1999 | Eur Arch Psychiatry Clin Neurosci1999，249，6： | 1 |
| 7 | Resonant and off-resonant light-driven plasmons in metal nanoparticles studied by femtosecond-resolution third-harmonic genera- tion显示文摘 | Lamprecht B Krenn J R Leimer A etal | 1999 | Physical Review Letters1999，83，21： | 1 |
| 8 | Genes and mechanisms in- volved in beta amyloid generation and Alzheimer's disease显示文摘 | Steiner H Cape!l A Leimer U | 1999 | Eur Arch Psychiatry Clin Neurosei1999，249，6： | 1 |
| 9 | Response to treatment with yttrium 90-DOTA-lanreotide of a patient with metastatic gastrinoma显示文摘 | Leimer M Kurtaran A Smith-Jones P | 1998 | J Nucl Med1998，39，12： | 1 |
| 10 | The diagnosis and conservative treatment of a complex type 3 dens invaginatus using cone beam computed tomography (CBCT) and 3D plastic models显示文摘 | Kfir A Telishevsky-Strauss Y Leimer A | 2013 | Int Endod J2013，46，3： | 1 |
| 11 | The dynamics of an- tibody response to Eseheriehia eoli vaccination in meat-type chicks显示文摘 | Yonash N Leimer G Cahaner A | 2010 | Poultry Science2010，79，： | 1 |
| 12 | Impact o frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes显示文摘 | Anzueto A Leimer 1 Kesten S | 2009 | Int J Chron Obstruct Pulmon Dis2009，4，： | 1 |
| 13 | Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways显示文摘 | AMBREE O LEIMER U HERRING A | 2006 | Am J Pathol2006，169，2： | 1 |
| 14 | Impact of frequency of COPD exacerbations of pulmonary function,health status and clinical outcomes显示文摘 | Anzuetol A Leimer I Kesten S | 2009 | Int J Chron Obstruct Pulmon Dis2009，4，2： | 1 |
| 15 | In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts显示文摘BACKGROUND Mesenchymal stem cells(MSC)modified by gene transfer to express cardiac pacemaker channels such as HCN2 or HCN4 were shown to elicit pacemaker function after intracardiac transplantation in experimental animal models.Human MSC derived from adipose tissue(haMSC)differentiate into cells with pacemaker properties in vitro,but little is known about their behavior after intracardiac transplantation.AIM To investigate whether haMSC elicit biological pacemaker function in vivo after transplantation into pig hearts.METHODS haMSC under native conditions(nhaMSC)or after pre-conditioning by medium differentiation(dhaMSC)(n=6 pigs each,5×106 cells/animal)were injected into the porcine left ventricular free wall.Animals receiving PBS injection served as controls(n=6).Four weeks later,total atrioventricular(AV)-block was induced by radiofrequency catheter ablation,and electronic pacemaker devices were implanted for backup stimulation and heart rate monitoring.Ventricular rate and rhythm of pigs were evaluated during a follow-up of 15 d post ablation by 12-lead-ECG with heart rate assessment,24-h continuous rate monitoring recorded by electronic pacemaker,assessment of escape recovery time,and pharmacological challenge to address catecholaminergic rate response.Finally,hearts were analyzed by histological and immunohistochemical investigations.RESULTS In vivo transplantation of dhaMSC into the left ventricular free wall of pigs elicited spontaneous and regular rhythms that were pace-mapped to ventricular injection sites(mean heart rate 72.2±3.6 bpm;n=6)after experimental total AV block.Ventricular rhythms were stably detected over a 15-d period and were sensitive to catecholaminergic stimulation(mean maximum heart rate 131.0±6.2 bpm;n=6;P<0.001).Pigs,which received nhaMSC or PBS presented significantly lower ventricular rates(mean heart rates 47.2±2.5 bpm and 37.4±3.2 bpm,respectively;n=6 each;P<0.001)and exhibited little sensitivity towards catecholaminergic stimulation(mean maximum heart rates 76.4±3.1 bpm and 60.5±3.1 bpm,respectively;n=6 each;P<0.05).Histological and immunohistochemical evaluation of hearts treated with dhaMSC revealed local clusters of transplanted cells at the injection sites that lacked macrophage or lymphocyte infiltrations or tumor formation.Intense fluorescence signals at these sites indicated membrane expression of HCN4 and other pacemaker-specific proteins involved in cardiac automaticity and impulse propagation.CONCLUSION dhaMSC transplanted into pig left ventricles sustainably induced rate-responsive ventricular pacemaker activity after in vivo engraftment for four weeks.The data suggest that pre-conditioned MSC may further differentiate along a pacemakerrelated lineage after myocardial integration and may establish superior pacemaker properties in vivo. | Fabrice F Darche Rasmus Rivinius Ann-Kathrin Rahm Eva Köllensperger Uwe Leimer Günter Germann Miriam Reiss Michael Koenen Hugo A Katus Dierk Thomas Patrick A Schweizer | 2020 | World Journal of Stem Cells2020，12，10： | 0 |
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