|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Campylobacter concisus and inflammatory bowel disease显示文摘Investigation of the possible role of Campylobacter concisus(C. concisus) in inflammatory bowel disease(IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin(zot) gene from a virus(prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD. | Li Zhang Hoyul Lee Michael C Grimm Stephen M Riordan Andrew S Day Daniel A Lemberg | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 2 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 3 | Obesity and the metabolic syndrome 显示文摘 | Keller KB Lemberg C | 2003 | Am J Crit Care2003，12，2： | 1 |
| 4 | Cardiovascular Autonomic Dysfunction and hemodynamic response to anesthetic Iinduction in patients with coronary artery disease and diabetes mellitus显示文摘 | Keyl C Lemberger P Palitzsch KD | 1999 | Anesth Analg1999，88，5： | 1 |
| 5 | In vivo cartilage deformation after different types of activity and its dependence on physical training status 显示文摘 | Eckstein F Lemberger B Gratzke C | 2005 | Ann Rheum Dis2005，64，2： | 1 |
| 6 | Disruption of CREB function in brain leads to neurodegeneration 显示文摘 | Mantamadiotis T Lemberger T Bleckmann S C | 2002 | Nat Genet2002，31，11： | 1 |
| 7 | A comparision of the use of transoesophageal dopper and thermodilution techniques for cardiac output detemination显示文摘 | Keyl C |lodig G Lemberger P et a/ | 1996 | Eur Anaesthesiol1996，13，2： | 1 |
| 8 | SLALoM: ascalable location management scheme for large mobile ad-hoc networks 显示文摘 | Cheng C T Lemberg H L Philip S J | 2002 | Wireless Communications and Networ-king Conference2002，，： | 1 |
| 9 | The school boundary stability problem over lime显示文摘 | Lemberg D S C | 2000 | Socio-Economie Planning Sciences2000，34，3： | 1 |
| 10 | PPAR tissue distribution and interactions with other hormone-sig- naling pathways 显示文摘 | Lemberger T Braissant O Juge-Aubry C | 1996 | Ann N Y Acad Sci1996，804，： | 1 |
| 11 | Disruption of CREB function in brain leads to neurodegeneration 显示文摘 | Mantamadiotis T Lemberger T Bleckmann S C | 2002 | Nat Genet2002，31，1： | 1 |
| 12 | Perioperative changes in cardiac autonomic control in patients recerving either general or local anesthesia for ophthalmic surgery 显示文摘 | Lemberger P Frey AW | 1996 | Anesth Analg1996，82，： | 1 |
| 13 | PPAR tissue distribution and interactions with other hormone-signaling pathways显示文摘 | Lemberger T Braissant O Juge - Aubry C | 1996 | Ann N Y Acad Sci1996，804，： | 1 |
| 14 | Disruption of CREB function in brain leads to neuro degeneration显示文摘 | Mantamadiotis T Lemberger T Bleckmann S C etal | 2002 | Nat Genet2002，31，1： | 1 |
| 15 | Disruption of CREB function in brain leads to neurodegeneration显示文摘 | Mantamadiotis T Lemberger T Bleckmann S C | 2002 | Nat Genet2002，31，1： | 1 |
| 16 | Phosphorylafion of CREB Ser-142 regulates light-induced phase shifts of the circadian clock显示文摘 | Gau D Lemberger T von Gall C et cd | 2002 | Neuron2002，34，： | 1 |
| 17 | Phosphorylation of CREB Ser142 regulates light -induced phase shifts of the circadian clock显示文摘 | Gau D Lemberger T von Gall C | 2002 | Neuron2002，34，2： | 1 |
| 18 | PPAR tissue distribution and interactions with other hormone-signaling pathways显示文摘 | Lemberger T Braissant O Juge-Aubry C | 1996 | Arm NY Acad Sci1996，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员