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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Biodistribution of ^68Ga-labelled Phosphodiester, Phosphorothioate, and 2'-O-methyl Phosphodiester Oligonueleotides in Normal Rats显示文摘 | LENDVAI G VELIKYAN I BERGSTROM M | 2005 | EurJ Pharm Sci2005，26，： | 1 |
| 3 | 显示文摘 | Zs Kovács A Castellero A L Lendvai G J | 2004 | Materials Science and Engineering2004，，： | 1 |
| 4 | Mechanical properties of AIZnMg alloys 显示文摘 | KOVACS I LENDVAI J UNGAR T GROMA G LAKNER J | 1980 | Acta Metallurgica1980，28，12： | 1 |
| 5 | Biodistribution of 68Ga-labelled phosphodiester,phosphorothioate,and 2'-O-methyl phosphodiester oligonucleotides in normal rats显示文摘 | Lendvai G Velikyan I Bergstrom M | | 0，，： | 1 |
| 6 | Conserved functions of retinoblastoma proteins from purple retina to green plant cells 显示文摘 | Miskolczi P Lendvai A Horvfith G V | 2007 | Plant Sci2007，172，4： | 1 |
| 7 | Chemieal rteuropro- tection in the cochlea: the modulation of dopamine release fromlatera olivocochlear efferents 显示文摘 | Lendvai t3 Halmos G B Pohmy G | 2011 | Neurochem Int2011，59，2： | 1 |
| 8 | Chemical neuroprotection in the cochlea: The modulation of dopamine release from lateral olivocochlear efferents显示文摘 | Lendvai B Halmos GB Polony G | 2011 | Neurochemistry International2011，150，： | 1 |
| 9 | Indentation creep in a short fibre-reinforced metal matrix composite显示文摘 | G Cseh J B?r H.-J Gudladt J Lendvai A Juhász | 1999 | Materials Science & Engineering A1999，，1： | 1 |
| 10 | Biodistribution of 68Ga-labelled phosphodiester,phosphorothioate,and 2'-O-methyl phosphodiester oligonucleotides in normal rats 显示文摘 | Lendvai G Velikyan I Bergstrom M | 2005 | Eur J Pharm Sci2005，26，1： | 1 |
| 11 | An ab i ntio study of the three-channel reaction between methanol and hydrogen atoms: BAC-MP4 and gaussian-2 calculation显示文摘 | Lendvay G Berces T Marta F | 1997 | J Phys Chem A1997，101，： | 1 |
| 12 | Some difficulties in computing BSSE-corrected potential surfaces of chemical reactions显示文摘 | LENDVAY G MAYER I | 1998 | Chem Phys Lett1998，297，516： | 1 |
| 13 | Biodistribution of 68Ga-labelled phosphodiester,phosphorothioate,and 2′-Omethyl phosphodiester oligonucleotides in normal rats显示文摘 | Lendvai G Velikyan I Bergstrm M | 2005 | Eur J Pharm Sci2005，26，1： | 1 |
| 14 | Quasiclassical Trajectory and Transition State Theory Studies of the N(4S)+ Hz'- NH (X3E- )+H Reaction显示文摘 | Paseual R Z Schatz G C Lendvay G | 2002 | J Phys Chem A2002，106，16： | 1 |
| 15 | Biodistribution of 68Galabeled LNA-DNA mixmer antisense oligonucleotides for rat chromogranin-A显示文摘 | Lendvai G Velikyan I Estrada S | | 0，，01： | 1 |
| 16 | Biodistribution of ^68Gaolabelled phosphodiester,phosphorothioate,and 2'-O-methyl phosphodiester oligonucleotides in normal rats显示文摘 | Lendvai G Velikyan I Bergstrom M | 2005 | Eur J Pharm Sci2005，26，1： | 1 |
| 17 | Aherations in microRNA expression patterns in liver diseases显示文摘 | Lendvai G Kiss A Kovalszky l et ai | 2010 | Orv Hetil2010，151，45： | 1 |
| 18 | Photocatalytic Degradation of 1,5-Naphthalenedisulfonate on Colloidal Titanium Dioxide显示文摘 | Szabó-Bárdos E Zsilák Z Lendvay G | | 0，，46： | 1 |
| 19 | Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease显示文摘 | Nóra J. Béres Dolóresz Szabó Dorottya Kocsis Dániel Sz?cs Zoltán Kiss Katalin E. Müller Gábor Lendvai András Kiss András Arató Erna Sziksz ádám Vannay Attila J. Szabó Gábor Veres | 2016 | Inflammatory Bowel Diseases2016，，2： | 1 |
| 20 | On the correlation of bond order and bond length显示文摘 | Lendvay G | 2000 | Journal of Molecular Structure(Theochem)2000，，： | 1 |
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