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| 1 | Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma显示文摘In recent decades there has been a dramatic rise in the incidence of esophageal adenocarcinoma(EAC) in the developed world. Over approximately the same period there has also been an increase in the prevalence of obesity. Obesity, especially visceral obesity, is an important independent risk factor for the development of gastro-esophageal reflux disease, Barrett's esophagus and EAC. Although the simplest explanation is that this mediated by the mechanical effects of abdominal obesity promoting gastro-esophageal reflux, the epidemiological data suggest that the EAC-promoting effects are independent of reflux. Several, not mutually exclusive, mechanisms have been implicated, which may have different effects at various points along the refluxBarrett's-cancer pathway. These mechanisms include a reduction in the prevalence of Helicobacter pylori infection enhancing gastric acidity and possibly appetite byincreasing gastric ghrelin secretion, induction of both low-grade systemic inflammation by factors secreted by adipose tissue and the metabolic syndrome with insulin-resistance. Obesity is associated with enhanced secretion of leptin and decreased secretion of adiponectin from adipose tissue and both increased leptin and decreased adiponectin have been shown to be independent risk factors for progression to EAC. Leptin and adiponectin have a set of mutually antagonistic actions on Barrett's cells which appear to influence the progression of malignant behaviour. At present no drugs are of proven benefit to prevent obesity associated EAC. Roux-en-Y reconstruction is the preferred bariatric surgical option for weight loss in patients with reflux. Statins and aspirin may have chemopreventative effects and are indicated for their circulatory benefits. | Leo Alexandre Elizabeth Long Ian LP Beales | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 1 |
| 2 | PROSTATE CANCER DETECTION IN MEN WITH PROSTATE SPECIFIC ANTIGEN 4 TO 10 NG/ML USING A COMBINED APPROACH OF CONTRAST ENHANCED COLOR DOPPLER TARGETED AND SYSTEMATIC BIOPSY显示文摘 | ALEXANDRE PELZER JASMIN BEKTIC ANDREAS P. BERGER LEO PALLWEIN ETHAN J. HALPERN WOLFGANG HORNINGER GEORG BARTSCH FERDINAND FRAUSCHER | 2005 | The Journal of Urology2005，，6： | 1 |
| 3 | Value of magnetic resonance imaging in prostate cancer diagnosis显示文摘 | Friedrich A Leo P Alexandre P | 2007 | World Journal of Urology2007，25，4： | 1 |
| 4 | Value of magnetic resonance imaging in prostate cancer diagnosis显示文摘 | Friedrich A Leo P Alexandre P | 2007 | World Journal of Urology2007，25，4： | 1 |
| 5 | Frequency, Clinical Presentation and Evolution of Renal Oncocytomas: Multicentric Experience from a European Database显示文摘 | Leo Romis Luca Cindolo Jean Jacques Patard Giovanni Messina Vincenzo Altieri Laurent Salomon Claude Clement Abbou Dominique Chopin Bernard Lobel Alexandre de La Taille | 2003 | European Urology2003，，1： | 1 |
| 6 | Theplant cytosolic m^(6)A RNA methylome stabilizes photosynthesis in the cold显示文摘The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis,growth,and crop yield.Here,we showed that three abiotic perturbations—heat,cold,and high light—triggered considerable changes in the expression signatures of 42 epitranscriptomic factors(writers,erasers,and readers)with putative chloroplast-associated functions that formed clusters of commonly expressed genes in Arabidopsis.The expression changes under all conditions were reversible upon deacclimation,identifying epitranscriptomic players as modulators in acclimation processes.Chloroplast dysfunctions,particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOME UNCOUPLED-independent manner,triggered retrograde signals to remodel chloroplastassociated epitranscriptomic expression patterns.N6-methyladenosine(m^(6)A)is known as the most prevalent RNA modification and impacts numerous developmental and physiological functions in living organisms.During cold treatment,expression of components of the primary nuclear m^(6)A methyltransferase complex was upregulated,accompanied by a significant increase in cellular m^(6)A mRNA marks.In the cold,the presence of FIP37,a core component of the writer complex,played an important role in positive regulation of thylakoid structure,photosynthetic functions,and accumulation of photosystemⅠ,the Cytb6f complex,cyclic electron transport proteins,and Curvature Thylakoid1 but not that of photosystemⅡcomponents and the chloroplast ATP synthase.Downregulation of FIP37 affected abundance,polysomal loading,and translation of cytosolic transcripts related to photosynthesis in the cold,suggesting m^(6)Adependent translational regulation of chloroplast functions.In summary,we identified multifaceted roles of the cellular m^(6)A RNA methylome in coping with cold;these were predominantly associated with chloroplasts and served to stabilize photosynthesis. | Alexandre Magno Vicente Nikolay Manavski Paul Torben Rohn Lisa-Marie Schmid Antoni Garcia-Molina Dario Leister Charlotte Seydel Leo Bellin Torsten Möhlmann Gregor Ammann Stefanie Kaiser Jörg Meurer | 2023 | Plant Communications2023，4，6： | 0 |
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