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| 1 | Sirtuin deacetylases in neurodegenerative diseases of aging显示文摘Sirtuin 酶是高度保存的蛋白质 deacetylases 的一个家庭为他们的活动取决于菸碱腺嘌 dinucleotide (NAD+) 。在哺乳动物有七 sirtuins,这些蛋白质被 modulating 精力新陈代谢, genomic 稳定性和压力抵抗与热量的限制和老化连接了。Sirtuin 酶是在包括癌症,糖尿病,煽动性的混乱和 neurodegenerative 疾病的许多人的疾病的潜在的治疗学的目标。sirtuin 活动的调整被显示了包括 Alzheimer 的疾病影响几形成总数的 neurodegenerative 混乱的功课, Parkinson 的疾病,亨廷顿的疾病, amyotrophic 侧面的硬化和针、球根的肌肉发达的萎缩。Sirtuins 能由 modulating 抄写因素活动并且直接影响 neurodegenerative 混乱的前进 deacetylating proteotoxic 种类。这里,我们在几形成总数的 neurodegenerative 疾病描述 sirtuin 蛋白质目标并且讨论在这些混乱调制 sirtuin 活动的混合物的治疗学的潜力。 | Adrianna Z Herskovits Leonard Guarente | 2013 | Cell Research2013，23，6： | 13 |
| 2 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | Strain improve- ment of recombinant Escherichia coli for efficient produc- tion of plant flavonoids 显示文摘 | Leonard E Yan Y Fowler Z L | 2008 | Molecular Pharmaceutics2008，5，2： | 1 |
| 4 | Hematopoiesis : an evolving paradigm for stem cell biology 显示文摘 | STUART H O LEONARD I Z | 2008 | Cell2008，132，： | 1 |
| 5 | On lifetime-based node failure and stochastic resilience of decentralized peer-to-peer networks 显示文摘 | LEONARD D YAO Z RAI V | 2007 | IEEE/ACM Trans on Networking2007，15，3： | 1 |
| 6 | An assessment of the effects of central interleukin-1 β , -2, -6, and tumor necrosis factor- α administration on some behavioural, neurochemical, endocrine and immune parameters in the rat显示文摘 | T.J Connor C Song B.E Leonard Z Merali H Anisman | 1998 | Neuroscience1998，，3： | 1 |
| 7 | Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalls 显示文摘 | Skottrup P D Leonard P Kaczmarek J Z | 2011 | Analy Bioehem2011，415，2： | 1 |
| 8 | Increased atherosclerosis in hyperlipidemic mice deficient in a-tocopherol transfer protein and vitamin E显示文摘 | Terasawa Y Ladha Z Leonard S W | 2000 | PNAS2000，97，13： | 1 |
| 9 | The behavioral consequences of service quality显示文摘 | VALARIE A Z LEONARD L B | 1996 | Journal of Marketing1996，60，2： | 1 |
| 10 | Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha 显示文摘 | CHEN F ZHANG Z LEONARD S S | 2001 | Oncogene2001，20，27： | 1 |
| 11 | The Bootstrap and Lyapunov Exponents in Deterministic Chaos显示文摘 | Leonard A S Jurgen K | 1999 | Nonlinear Phenomena:Physica D1999，126，： | 1 |
| 12 | Presence of a family of plasmids (29 to 65 kilobases) with a 26-kilobase common region in different strains of the sulfur-oxidizing bacterium acidithiobacillus caldus显示文摘 | LEONARD J Z DEANE M LILLY A L | 2008 | Appl and Environ Microbiol2008，74，14： | 1 |
| 13 | Six degree- of- freedom active vibration control using the Stewart platforms显示文摘 | Geng Z Jason Haynes Leonard S | 1994 | IEEE Transactions on Control Systems Technology1994，2，1： | 1 |
| 14 | Six Degree-of-Freedom Active Vibration Control Using the Stewart Platforms显示文摘 | Z Jason Geng Leonard S Haynes | 1994 | IEEE Transactions on Control systems Technology March1994，2，1： | 1 |
| 15 | Role of reactive oxygen species and MAPKs in vanadate-indueed G(2)/M phase arrest显示文摘 | Zhang Z Leonard SS Huang C | 2003 | Free Radic Biol Med2003，34，10： | 1 |
| 16 | Luteal Phase Support for Frozen Embryo Transfers: Does Route of Progesterone Administration Make a Difference?显示文摘 | Leonard PH Hokenstad AN Khan Z | 2013 | Fertil Steril2013，99，3： | 1 |
| 17 | A novel nitrite biosensor based on conductometric electrode modified with cytochrome c nitrite reductase composite membrane显示文摘 | Zhang Z Q Xia S Q Leonard D | 2009 | Biosensors & Bioelectronics2009，24，6： | 1 |
| 18 | Energy-efficient transmission for MIMO interference channels显示文摘 | JIANG C Z LEONARD C | 2013 | IEEE Transactions on Wireless Communica- tions2013，12，9： | 1 |
| 19 | Independent factors associated with major depres- sive disorder in a national sample of individuals with diabetes 显示文摘 | Leonard EE Deyi Z | 2003 | Diabetes Care2003，26，1： | 1 |
| 20 | Hierarchically mesoporous/macroporous metal oxides templated from polyethylene oxide surfactant assemblies显示文摘 | Blin J L Leonard A Yuan Z Y | 2003 | Angew Chem Int Ed2003，42，： | 1 |
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