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| 1 | Sirtuin deacetylases in neurodegenerative diseases of aging显示文摘Sirtuin 酶是高度保存的蛋白质 deacetylases 的一个家庭为他们的活动取决于菸碱腺嘌 dinucleotide (NAD+) 。在哺乳动物有七 sirtuins,这些蛋白质被 modulating 精力新陈代谢, genomic 稳定性和压力抵抗与热量的限制和老化连接了。Sirtuin 酶是在包括癌症,糖尿病,煽动性的混乱和 neurodegenerative 疾病的许多人的疾病的潜在的治疗学的目标。sirtuin 活动的调整被显示了包括 Alzheimer 的疾病影响几形成总数的 neurodegenerative 混乱的功课, Parkinson 的疾病,亨廷顿的疾病, amyotrophic 侧面的硬化和针、球根的肌肉发达的萎缩。Sirtuins 能由 modulating 抄写因素活动并且直接影响 neurodegenerative 混乱的前进 deacetylating proteotoxic 种类。这里,我们在几形成总数的 neurodegenerative 疾病描述 sirtuin 蛋白质目标并且讨论在这些混乱调制 sirtuin 活动的混合物的治疗学的潜力。 | Adrianna Z Herskovits Leonard Guarente | 2013 | Cell Research2013，23，6： | 13 |
| 2 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin显示文摘 | Petra Simic Kayvan Zainabadi Eric Bell David B. Sykes Borja Saez Sutada Lotinun Roland Baron David Scadden Ernestina Schipani Leonard Guarente | 2013 | EMBO Mol Med2013，，3： | 2 |
| 3 | SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle显示文摘 | Takashi Nakagawa David J. Lomb Marcia C. Haigis Leonard Guarente | 2009 | Cell2009，，3： | 2 |
| 4 | SIRT1 deacetylates and positively regulates the nuclear receptor LXR显示文摘 | Xiaoling li Songwen Zhang Leonard Guarente | 2007 | Molecular Cell2007，28，1： | 1 |
| 5 | hSIR2 SIRT1 Functions as an NAD-Dependent p53 Deacetylase显示文摘 | Homayoun Vaziri Scott K. Dessain Elinor Ng Eaton Shin-Ichiro Imai Roy A. Frye Tej K. Pandita Leonard Guarente Robert A. Weinberg | 2001 | Cell2001，，： | 1 |
| 6 | Mammalian SIRT1 Represses Forkhead Transcription Factors显示文摘 | Maria Carla Motta Nullin Divecha Madeleine Lemieux Christopher Kamel Delin Chen Wei Gu Yvette Bultsma Michael McBurney Leonard Guarente | 2004 | Cell2004，，： | 1 |
| 7 | SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging显示文摘 | Hung-Chun Chang Leonard Guarente | 2013 | Cell2013，，7： | 1 |
| 8 | hSIR2 SIRT1 Functions as an NAD-Dependent p53 Deacetylase显示文摘 | Homayoun Vaziri Scott K. Dessain Elinor Ng Eaton Shin-Ichiro Imai Roy A. Frye Tej K. Pandita Leonard Guarente Robert A. Weinberg | 2001 | Cell2001，，2： | 1 |
| 9 | Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease显示文摘 | Su-Ju Lin Leonard Guarente | 2003 | Current Opinion in Cell Biology2003，，2： | 1 |
| 10 | SIRTI Suppresses the Epithelial - to - Mesenehymal Transition in Caneer Metastasis and Organ Fibrosis显示文摘 | Petra Simic Leonard Guarente Bell EL | 2013 | Cell Rep2013，3，4： | 1 |
| 11 | SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice显示文摘 | Yao Hongwei Chung Sangwoon Hwang Jae-woong Rajendrasozhan Saravanan Sundar Isaac K Dean David A McBurney Michael W Guarente Leonard Gu Wei R?nty Mikko Kinnula Vuokko L Rahman Irfan | 2012 | EN2012，，6： | 1 |
| 12 | SIRT1 and other sirtuins in metabolism显示文摘 | Hung-Chun Chang Leonard Guarente | 2013 | Trends in Endocrinology & Metabolism2013，，： | 1 |
| 13 | High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction显示文摘 | Angeliki Chalkiadaki Leonard Guarente | 2012 | Cell Metabolism2012，，2： | 1 |
| 14 | SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10显示文摘 | Gizem Donmez Diana Wang Dena E. Cohen Leonard Guarente | 2010 | Cell2010，，2： | 1 |
| 15 | SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR显示文摘 | Xiaoling Li Songwen Zhang Gil Blander Jeanette G. Tse Monty Krieger Leonard Guarente | 2007 | Molecular Cell2007，，1： | 1 |
| 16 | Aging Research—Where Do We Stand and Where Are We Going?显示文摘 | Leonard Guarente | 2014 | Cell2014，，1： | 1 |
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