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您的检索式：作者名="Leonel Rodriguez"
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| 1 | Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children显示文摘 | Leonel Rodriguez Katayun Irani Hongyu Jiang Allan M. Goldstein | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，2： | 1 |
| 2 | Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children显示文摘More than a century has elapsed since the identification of Clostridia neurotoxins as the cause of paralytic diseases. Clostridium botulinum is a heterogeneous group of Gram-positive, rod-shaped, spore-forming, obligate anaerobic bacteria that produce a potent neurotoxin. Eight different Clostridium botulinum neurotoxins have been described(A-H) and 5 of those cause disease in humans. These toxins cause paralysis by blocking the presynaptic release of acetylcholine at the neuromuscular junction. Advantage can be taken of this blockade to alleviate muscle spams due to excessive neural activity of central origin or to weaken a muscle for treatment purposes. In therapeutic applications, minute quantities of botulinum neurotoxin type A are injected directly into selected muscles. The Food and Drug Administration first approved botulinum toxin(BT) type A in 1989 for the treatment of strabismus and blepharospasm associated with dystonia in patients 12 years of age or older. Ever since, therapeutic applications of BT have expanded to other systems, including the gastrointestinal tract. Although only a single fatality has been reported to our knowledge with use of BT for gastroenterological conditions, there are significant complications ranging from minor pain, rash and allergic reactions to pneumothorax, bowel perforation and significant paralysis of tissues surrounding the injection(including vocal cord paralysis and dysphagia). This editorial describes the clinical experience and evidence for the use BT in gastrointestinal motility disorders in children. | Ricardo A Arbizu Leonel Rodriguez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 1 |
| 3 | Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction显示文摘 | Katy Irani Leonel Rodriguez Daniel P. Doody Allan M. Goldstein | 2008 | Pediatric Surgery International2008，，7： | 1 |
| 4 | Hirschsprung's disease associated enterocolitis:A comprehensive review显示文摘Hirschsprung’s disease(HSCR)is a congenital disorder characterized by failure of the neural crest cells to migrate and populate the distal bowel during gestation affecting different lengths of intestine leading to a distal functional obstruction.Surgical treatment is needed to correct HSCR once the diagnosis is confirmed by demonstrating the absence of ganglion cells or aganglionosis of the affected bowel segment.Hirschsprung’s disease associated enterocolitis(HAEC)is an inflammatory complication associated with HSCR that can present either in the pre-or postoperative period and associated with increased morbidity and mortality.The pathogenesis of HAEC remains poorly understood,but intestinal dysmotility,dysbiosis and impaired mucosal defense and intestinal barrier function appear to play a significant role.There is no clear definition for HAEC,but the diagnosis is primarily clinical,and treatment is guided based on severity.Here,we aim to provide a comprehensive review of the clinical presentation,etiology,pathophysiology,and current therapeutic options for HAEC. | Eric M Gershon Leonel Rodriguez Ricardo A Arbizu | 2023 | World Journal of Clinical Pediatrics2023，12，3： | 0 |
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