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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Intrinsic mo tivations and exercise adherence显示文摘 | RYAN R M FREDERICK C M LEPES D | 1997 | Int J Sport Psychol1997，28，： | 1 |
| 3 | Applications of the GA/KNN Method to SELDI Proteomics Data显示文摘 | Li Leping Umbach D M Terry P | 2004 | Bioinformatics2004，20，10： | 1 |
| 4 | Alpha fetoprotein,ultrasound,computerized tomography and magnetic resonance imaging for detection of hepatocellular carcinoma in patients with advanced cirrhosis显示文摘 | SNOWBERGER N CHINNAKOTLA S LEPE R M | | 0，，09： | 1 |
| 5 | Meningitis in Children:Diagnosis and Treatment for the Emergency Clinician显示文摘 | Richard GC Lepe M | 2013 | Elsevier Inc2013，14，2： | 1 |
| 6 | Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity显示文摘 | Letelier M E Lepe A M Faundez M | 2005 | ChemicoBiological Interactions2005，151，2： | 1 |
| 7 | In vitro and intracellular activities of fosfomycin against clinical strains of Listeria monocytogenes显示文摘 | Lepe J A Torres M J Smani Y | 2014 | International Journal of Antimicrobial Agents2014，43，2： | 1 |
| 8 | Possible mecha- nisms underlying copper-induced damage in biological mem- branes leading to cellular toxicity显示文摘 | Letelier M E Lepe A M Fat:ndez M | 2005 | Chemico-Biological Inter- actions2005，151，2： | 1 |
| 9 | C]inical success of class V composite resin restorations without mechanical retention显示文摘 | McCoy R B Anderson M H Lepe X | 1998 | J Am Dent Assoc1998，129，5： | 1 |
| 10 | Viscous dark energy and phantom evolution 显示文摘 | Cataldo M Cruz N Lepe S | 2005 | Phys Lett B2005，619，： | 1 |
| 11 | Applications of the GA/KNN Method to SELDI Proteomics Data显示文摘 | Li Leping Umbach D M Terry P | 2004 | Bioinformatics2004，20，10： | 1 |
| 12 | Tracheostomy: Complications in fresh postoperative and late postoperative settings 显示文摘 | CARDONE G LEPE M | 2010 | Clin Ped Emerg Med2010，11，2： | 1 |
| 13 | Intrinsic mo- tivation and exercise adherence 显示文摘 | RYAN R M FREDERICK C M LEPES D | 1997 | Int J Sport Psychol1997，28，4： | 1 |
| 14 | Laboratory diagnosis and nonoperative management of biliary complications in living donor liver transplant patients显示文摘 | VENU M BROWN R D LEPE R | 2007 | J Clin Gastroenterol2007，41，5： | 1 |
| 15 | Worldwide emergence of extensively drug-resistant tuber culosis显示文摘 | Shah NS Wright A Bai GH Barrera L Boulahbal F Martin-Casabona N Drobniewski F Gilpin C Havelkova M Lepe R Lumb R Metchock B Portaels F Rodrigues MF Rusch-Gerdes S Van Deun A Vincent V Laserson K Wells C Cegiels ki JP | 2007 | Emerg Infect Dis2007，13，3： | 1 |
| 16 | Laboratory diagnosis and nonoperative management of biliary complications in living donor liver traosplant patients 显示文摘 | Venu M Brown RD Lepe R | 2007 | J Clin Gastroenterol2007，41，： | 1 |
| 17 | Intrinsic motivations and exercise adherence显示文摘 | Ryan R M Frederick C M Lepes D | 1997 | International journal of Sport Psychology1997，，28： | 1 |
| 18 | Possible mecha- nisms underlying copper-induced damage in biological membranes leading to cellular toxicity 显示文摘 | Letelier M Lepe A Fa6ndez M | 2005 | Chemico-Bio- logical Interactions2005，151，2： | 1 |
| 19 | Long-term efficacy of high-protein diets : a systematic review 显示文摘 | Lepe M BacardiGascon M Jimenez Cruz A | 2011 | Nutr Hosp2011，26，6： | 1 |
| 20 | Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity显示文摘 | Letelier M E Lepe A M Faundez M | 2005 | Chem Biol Interact2005，151，2： | 1 |
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