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| 1 | Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury显示文摘Neglected for years, astrocytes are now recognized to fulfill and support many, if not all, homeostatic functionsof the healthy central nervous system(CNS). During neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS) and spinal cord injury(SCI), astrocytes in the vicinity of degenerating areas undergo both morphological and functional changes that might compromise their intrinsic properties. Evidence from human and animal studies show that deficient astrocyte functions or loss-of-astrocytes largely contribute to increased susceptibility to cell death for neurons, oligodendrocytes and axons during ALS and SCI disease progression. Despite exciting advances in experimental CNS repair, most of current approaches that are translated into clinical trials focus on the replacement or support of spinal neurons through stem cell transplantation, while none focus on the specific replacement of astroglial populations. Knowing the important functions carried out by astrocytes in the CNS, astrocyte replacement-based therapies might be a promising approach to alleviate overall astrocyte dysfunction, deliver neurotrophic support to degenerating spinal tissue and stimulate endogenous CNS repair abilities. Enclosed in this review, we gathered experimental evidence that argue in favor of astrocyte transplantation during ALS and SCI. Based on their intrinsic properties and according to the cell type transplanted, astrocyte precursors or stem cell-derived astrocytes promote axonal growth, support mechanisms and cells involved in myelination, are able to modulate the host immune response, deliver neurotrophic factors and provide protective molecules against oxidative or excitotoxic insults, amongst many possible benefits. Embryonic or adult stem cells can even be genetically engineered in order to deliver missing gene products and therefore maximize the chance of neuroprotection and functional recovery. However, before broad clinical translation, further preclinical data on safety, reliability and therapeutic efficiency should be collected. Although several technical challenges need to be overcome, we discuss the major hurdles that have already been met or solved by targeting the astrocyte populationin experimental ALS and SCI models and we discuss avenues for future directions based on latest molecular findings regarding astrocyte biology. | Charles Nicaise Dinko Mitrecic Aditi Falnikar Angelo C Lepore | 2015 | World Journal of Stem Cells2015，7，2： | 13 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes 显示文摘 | Rosenblatt-Velin N Lepore MG Cartoni C | 2005 | J Clin Invest2005，115，7： | 1 |
| 4 | An objective auditory measure to assess speech recognition in adult cochlear implant users显示文摘 | TURGEON C LAZZOUNI L LEPORE F | 2014 | Clin Neurophysiol2014，125，： | 1 |
| 5 | Early Removal of Urinary Catheter after Radical Retropuhie Prostatectomy Is Both Feasible and Desirable显示文摘 | Lepor H Nieder A M Fraiman M C | 2001 | Urology2001，58，： | 1 |
| 6 | An epidemiological analysis of retinopathy of prematurity over ten years 显示文摘 | Giannantonio C Papacci P Molle F Lepore D Gallini F Romag- noli C | 2008 | J Pediatr Ophthalmol Strabismus2008，45，3： | 1 |
| 7 | Pharmacokinetics and pharmacodynamics of subcutaneous injection of Long- Acting HumanInsulinAnalogGlargine, NPHInsulin, andUltra- lenteHuman Insulin and continuous subcutaneous infusion of Insulin Lispro显示文摘 | Lepore M Pampanell S Faneill C | 2000 | Diabetes2000，49，12： | 1 |
| 8 | Rainfall-induced land- slide susceptibility zonation of Puerto Rico显示文摘 | Lepore C Sameer A K Peter S | 2012 | Environ- mental Earth Sciences2012，，66： | 1 |
| 9 | FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes 显示文摘 | ROSENBLATT-VELIN N LEPORE MG CARTONI C | 2005 | J Clin Invest2005，115，： | 1 |
| 10 | Er: YAG laser treatments on dentine surface: micro- Raman spectroscopyand SEM analysis 显示文摘 | Camerlingo C Lepore M Gaeta GM | 2004 | J Dent2004，32，： | 1 |
| 11 | Er: YAG laser treatments ondentinesurface: micro-Raman spectroscopy and SEM analysis 显示文摘 | AMERLINGO C LEPORE M GAETA G M | 2004 | Journal of Dentistry2004，32，5： | 1 |
| 12 | Er:YAG laser treatments on dentine surface:Micro-Raman spectroscopy and SEM analysis显示文摘 | Camerlingo C Lepore M Gaeta GM | 2004 | J Dent2004，32，5： | 1 |
| 13 | Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women 显示文摘 | Alexander C J Tangchimob EP Lepor NE | 2009 | Rev Obstet Gynecoll2009，2，4： | 1 |
| 14 | Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro显示文摘 | Lepore M Pampanelli S Fanelli C | 2000 | Diabetes2000，49，12： | 1 |
| 15 | An objectiveauditory measure to assess speech recognition in adult cochlearimplant users显示文摘 | Turgeon C Lazzouni L Lepore F | 2014 | Clin Neurophysiol2014，125，4： | 1 |
| 16 | Er:YAG laser treatments on dentine surface: micro-Raman spectroscopy and SEM analysis显示文摘 | Carmelingo C Lepore M Gaeta GM | 2004 | Dent2004，32，： | 1 |
| 17 | Generalized tensor-basedmorphometry of HIV/AIDS using multivariate statistics on defor-mation tensors显示文摘 | Lepore N Brun C Chou YY | 2008 | IEEE Trans Med Imaging2008，27，1： | 1 |
| 18 | Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine,NPH insulin,and ultralente human insulin and continous subcutaneous infusion of insulin lispro显示文摘 | Lepore M Pampanelli S Fanelli C | 2000 | Diabetes2000，49，12： | 1 |
| 19 | Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro 显示文摘 | Lepore M Pampanelli S Fanelli C | 2000 | Diabetes2000，49，12： | 1 |
| 20 | Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro显示文摘 | Lepore M Pampanelli S Fanelli C | 2000 | Diabetes2000，49，12： | 1 |
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