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| 1 | Targeting mast cells in gastric cancer with special reference to bone metastases显示文摘Bone metastases from gastric cancer(GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells(MCs) positive to tryptase(MCPT) in primary gastric tumor angiogenesis. Recently,we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumorinfiltrating,peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents,such as MCs tryptase inhibitors(gabexate mesylate,nafamostat mesylate) or c-KitR tyrosine kinase inhibitors(imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patientsaffected by bone metastases. | Christian Leporini Michele Ammendola Ilaria Marech Giuseppe Sammarco Rosario Sacco Cosmo Damiano Gadaleta Caroline Oakley Emilio Russo Giovambattista De Sarro Girolamo Ranieri | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 2 | Sand transport in multiphase flow mixtures in a horizontal pipeline:An experimental investigation显示文摘An inherent problem with both oil and natural gas production is the deposition of sand particles in pipeline,which could lead to problems such as excessive pressure drops,equipment failure,pipeline erosion,and production decline.The characterization of sand particles transport and sedimentation in different flow systems such as sandemultiphase mixtures is vital to predict the sand transport velocity and entrainment processes in oil and gas transportation pipelines.However,it seems that no model exists able to accurately characterize the sand transport and deposition in multiphase pipeline.In fact,in the last decade several researchers tried to extend the modeling of liquid-solid flow to gas-liquid-solid flow,but no significant results have been obtained,especially in slug flow condition due to the complexity of the phenomenon.In order to develop and validate a mathematical model properly formulated for the calculation of the sand critical deposition velocity in gas-liquid flow,more and more experimental data are necessary.This paper presents a preliminary experimental study of three phase flows(air-water-sand)inside a horizontal pipe and the application of the sand-liquid models present in literature.Significant observations were made during the experimental study from which several conclusions were drawn.Different sand flow regimes were established by physical observation and data analysis:fully dispersed solid flow,moving dunes and stationary bed.The critical deposition velocities were determined at different sand concentrations.It was concluded that sand transport characteristics and the critical deposition velocity are strongly dependent on the gas-liquid flow regime and on sand concentration. | Mariella Leporini Barbara Marchetti Francesco Corvaro Giuseppe di Giovine Fabio Polonara Alessandro Terenzi | 2019 | Petroleum2019，5，2： | 1 |
| 3 | Effect of phytochemical concentrations on biological activities of cranberry extracts显示文摘 | Menghini L Leporini L Scanu N | | 0，，01： | 1 |
| 4 | Targeting Mast Cells Tryptase in Tumor Microenvironment: A Potential Antiangiogenetic Strategy显示文摘 | Michele Ammendola Christian Leporini Ilaria Marech Cosmo Damiano Gadaleta Giovanni Scognamillo Rosario Sacco Giuseppe Sammarco Giovambattista De Sarro Emilio Russo Girolamo Ranieri Xiaokun Li | 2014 | BioMed Research International2014，，： | 1 |
| 5 | Bayesian wavelet denoising-Besov priors and non-Gaussian noises显示文摘 | Pesquet J C Leporini D | 2001 | Signal Processing2001，81，1： | 1 |
| 6 | Targeting mast cells tryptase in tumor microenvironment :a potential antiangiogenetic strat- egy 显示文摘 | Ammendola M Leporini C Marech I | 2014 | Biomed Res Int2014，2014，15： | 1 |
| 7 | Quantum computational logics and possible applications显示文摘 | Chiara M L D Giuntini R Leporini R di Francia G T | 2008 | Springer Science2008，47，1： | 1 |
| 8 | An Unsharp Logic from Quantum Computation显示文摘 | Gianpiero Cattaneo Maria Luisa Dalla Chiara Roberto Giuntini Roberto Leporini | 2004 | International Journal of Theoretical Physics (-)2004，，7： | 1 |
| 9 | Bayesian wavelet denoising: Besov priors and non-Gaussian noises 显示文摘 | Pesquet J C Leporini D | 2001 | Signal Processing (S0165-1684)2001，81，1： | 1 |
| 10 | Anti-vascular endothelial growth factor drugs safety and efficacy in ophthalmic diseases显示文摘 | Ventrice P Leporini C Aloe JF | | 0，，： | 1 |
| 11 | Lower Kppa with activated acidic hydrogen peroxide-a removal of lignin or hexenuronic acids显示文摘 | Sedss H U Leporini C Hopf B | 2005 | Appita2005，，： | 1 |
| 12 | A Natural Formulation Increases Brain Resistance to Oxidative Stress 显示文摘 | Menghini L Ferrante C Leporini L | 2014 | European Journal of Medicinal Plants2014，4，2： | 1 |
| 13 | An Unsharp Logic from Quantum Computation显示文摘 | Gianpiero Cattaneo Maria Luisa Dalla Chiara Roberto Giuntini Roberto Leporini | 2004 | International Journal of Theoretical Physics (-)2004，，7： | 1 |
| 14 | Lower Kappa with activated acidic hydrogen peroxide-a removal of lignin or hexenuronic acids显示文摘 | Suess H U Leporini C HopfB | | Appita0，2，： | 1 |
| 15 | Anti-vascular endothelial growth factor drugs safety and efficacy in ophthalmic diseases显示文摘 | Ventrice P Leporini C Aloe JF | 2013 | J Pharmacol Pharmacother2013，4，1： | 1 |
| 16 | Lower Kappa with ac-tivated acidic hydrogen peroxide-a removal of lignin or hex-enuronic acid显示文摘 | Suess H U Leporini C Hopf B | | 0，，： | 1 |
| 17 | Development and application of an innovative tool to automate the process of results extraction from the thermo-hydraulic simulator Olga显示文摘This paper presents the development and application of an innovative code to extract in an automated way data from the thermo-hydraulic simulator Olga.The results show that the tool can significantly reduce the time needed for the data extraction procedure and increase the reliability of results due to the fact that there is no more the need of the human operator.Moreover,during the data extraction phase,the Olga code is available for running different simulations allowing to optimize the use of this resource. | Francesco Carducci Antonio Del Monaco Giancarlo Giacchetta Mariella Leporini Barbara Marchetti | 2015 | Petroleum2015，1，2： | 0 |
| 18 | Pipeline wax deposition modeling:A sensitivity study on two commercial software显示文摘This paper presents the results of a sensitivity study carried out to investigate the performances of two commercial codes,OLGA and LedaFlow,used to model the wax deposition process in pipelines under multiphase flow.Reliable simulations of the phenomenon are essential to properly design pipelines and to adopt cost-effective strategies for prevention and removal of wax deposits,reducing the risks of blockage.The main limit of the available models is that their predictions depend on a number of parameters which are usually adjusted to fit the experimental data obtained from laboratory deposition tests.Since a reliable upscale criterion has not been developed yet,model predictions have been more suitably validated using real field data,reported in literature.The performances of the commercial codes in modelling wax precipitation and deposition have been compared to each other. | Giancarlo Giacchetta Barbara Marchetti Mariella Leporini Alessandro Terenzi Davide Dall’Acqua Laura Capece Roberta Cocci Grifoni | 2019 | Petroleum2019，5，2： | 0 |
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