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| 1 | Adult stem cells in neural repair: Current options, limitations and perspectives显示文摘Stem cells represent a promising step for the future of regenerative medicine. As they are able to differentiate into any cell type, tissue or organ, these cells are great candidates for treatments against the worst diseasesthat defy doctors and researchers around the world. Stem cells can be divided into three main groups:(1) embryonic stem cells;(2) fetal stem cells; and(3) adult stem cells. In terms of their capacity for proliferation, stem cells are also classified as totipotent, pluripotent or multipotent. Adult stem cells, also known as somatic cells, are found in various regions of the adult organism, such as bone marrow, skin, eyes, viscera and brain. They can differentiate into unipotent cells of the residing tissue, generally for the purpose of repair. These cells represent an excellent choice in regenerative medicine, every patient can be a donor of adult stem cells to provide a more customized and efficient therapy against various diseases, in other words, they allow the opportunity of autologous transplantation. But in order to start clinical trials and achieve great results, we need to understand how these cells interact with the host tissue, how they can manipulate or be manipulated by the microenvironment where they will be transplanted and for how long they can maintain their multipotent state to provide a full regeneration. | Eric Domingos Mariano Manoel Jacobsen Teixeira Suely Kazue Nagahashi Marie Guilherme Lepski | 2015 | World Journal of Stem Cells2015，7，2： | 3 |
| 2 | Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats显示文摘Neuropathic pain after spinal cord injury(SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy;nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the ability of fetal neural stem cells(fNSC) to relieve chronic pain and, secondarily, their effects on motor recovery. Adult Wistar rats with traumatic SCI were treated, 10 days after injury, with intra-spinal injections of culture medium(sham) or fNSCs extracted from telencephalic vesicles(TV group) or the ventral medulla(VM group) of E/14 embryos. Sensory(von Frey filaments and hot plate) and motor(the Basso, Beattie,Bresnahan locomotor rating scale and inclined plane test) assessments were performed during 8 weeks. Thereafter, spinal cords were processed for immunofluorescence and transplanted cells were quantified by stereology. The results showed improvement of thermal hyperalgesia in the TV and VM groups at 4 and 5 weeks after transplantation, respectively. Moreover, mechanical allodynia improved in both the TV and VM groups at 8 weeks. No significant motor recovery was observed in the TV or VM groups compared with sham. Stereological analyses showed that ~70% of TV and VM cells differentiated into NeuN+ neurons,with a high proportion of enkephalinergic and GABAergic cells in the TV group and enkephalinergic and serotoninergic cells in the VM group. Our study suggests that neuronal precursors from TV and VM, once implanted into the injured spinal cord, maturate into different neuronal subtypes, mainly GABAergic, serotoninergic, and enkephalinergic, and all subtypes alleviate pain, despite no significant motor recovery. The study was approved by the Animal Ethics Committee of the Medical School of the University of S?o Paulo(protocol number 033/14) on March 4, 2016. | Chary M. Batista Eric D. Mariano Camila S. Dale Alexandre F. Cristante Luiz R. Britto Jose P. Otoch Manoel J. Teixeira Matthias Morgalla Guilherme Lepski | 2019 | Neural Regeneration Research2019，14，11： | 3 |
| 3 | Investigation of foamy oil phenomena in heavy oil reservoirs 显示文摘 | Albartamani N S Farouq Ali S M Lepski B | 1999 | SPE 540841999，，： | 1 |
| 4 | Modeling the Influence of Process Parameters and Additional Heat Sources on Residual Stresses in Laser Cladding显示文摘 | Bruckner F Lepski D Beyer E | 2007 | Journal of Thermal Spray Technology2007，16，2： | 1 |
| 5 | Modeling the influence of process parameters and additional heat sources on residual stresses in laser cladding 显示文摘 | BRUCKNER F LEPSKI D BEYER E | 2007 | Journal of Thermal Spray Technology2007，16，3： | 1 |
| 6 | Cell Transplantation for Spinal Cord Injury: A Systematic Review显示文摘 | Jun Li Guilherme Lepski Xuan Jin | 2013 | BioMed Research International2013，，： | 1 |
| 7 | Induction assisted laser remelting of gray cast iron with different chromium contents显示文摘 | Wetzig A Lepski D Brenner B | 2000 | Lasers in Engineering2000，10，1： | 1 |
| 8 | Cell transplantation for spinal cord injury:a systema-tic review显示文摘 | Li J Lepski G | 2013 | Biomed Res Int2013，2013，78： | 1 |
| 9 | Analysis of the Discontinuous Galerkin Method for Hamilton-Jaeobi Equations 显示文摘 | Lepsky O Hu C Q Shu C W | 2000 | Appl Numer Math2000，33，： | 1 |
| 10 | Safe resection of arteriovenous malformations in eloquent motor areas aided by functional imaging and intraoperative monitoring显示文摘 | Lepski G Honegger J Liebsch M | 2012 | Neurosurgery2012，70，2： | 1 |
| 11 | Analysis of the discontinuous Galerkin method for HamiltonJacobi equations显示文摘 | LEPSKY O HU Chang-qing SHU Qi-wang | | 0，，： | 1 |
| 12 | Investigation of Foamy Oil Phenomena in Heavy Oil Reservoirs显示文摘 | N S Albartamani S M Farouq Ali B Lepski | | SPE0，5，： | 1 |
| 13 | Modeling the influence of process parameters and additional heat sources on residual stresses in laser cladding 显示文摘 | Brueckner F Lepski D Beyer E | 2007 | J Therm Spray Technol2007，16，： | 1 |
| 14 | Modeling the Influence of Process Parameters and Additional Heat Sources on Residual Stresses in Laser Cladding显示文摘 | F. Brückner D. Lepski E. Beyer | 2007 | Journal of Thermal Spray Technology2007，，3： | 1 |
| 15 | Delayed functional matu-ration of:uman neuronal progenitor cells in vitro 显示文摘 | Lepski G Maciaezyk J Jannes C E | 2011 | Mol Cell Neu-resci2011，47，1： | 1 |
| 16 | Emergency preparedness and professional competency among health care providers during hurricanes katrina and rita : Pilot study results 显示文摘 | Lepski LA | 2007 | Disaster Manag Response2007，5，4： | 1 |
| 17 | Investiga- tion of foamy oil phenomena in heavy oil reservoirs显示文摘 | Albartamani N S Farouq Ali S M Lepski B | 1999 | SPE 540841999，，： | 1 |
| 18 | Combined spinal cord and peripheral nerve field stimulation for persistent post-herniorrhaphy pain显示文摘 | Lepski G Vahedi P Tatagiba MS | | 0，，： | 1 |
| 19 | Limited Ca2+ and PKA-pat- hway dependent neurogenic differentiation of human adult mesenchy- mal stem cells as comparedto fetal neuronal stem cells 显示文摘 | Lepski G Jannes CE Maciaczyk J | 2010 | Exp Cell Res2010，，2： | 1 |
| 20 | Apoptosis in the uterus of mice with pregnancy loss显示文摘 | Savion S Lepsky E Orenstein H | 2002 | Am J Reprod Immunol2002，47，2： | 1 |
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