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47篇 您的检索式：作者名="Leung PL"

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	题名	作者	年代	出处	被引量
1	Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD.	Y Leung M Geddes J Storek R Panaccione PL Beck	2006	World Journal of Gastroenterology2006，12，41：	5
2	Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis:identification of a novel mutation in inhA显示文摘	Leung TE Ho PL Yuen KY	2006	Anti-microb Agents Chemother2006，50，3：	1
3	Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology 显示文摘	Leung MCK Williams PL Benedetto A	2008	Toxicol Sci2008，106，1：	1
4	Outcome in laparoscopic management of persistent adnexal mass during the second trimes- ter of pregnancy 显示文摘	Yuen PM Nq PS Leung PL	2004	Surg Endosc2004，18，9：	1
5	Accessibility and perceived clinical utility of the GMFM-66:evaluating therapists'judgements of a computer-based scoring program 显示文摘	Leung KM Rosenbaum PL	2003	Phys Occup Ther Pediatr2003，23，2：	1
6	Outcome in lapaoscopic management of persistent adnexal mass during the second trimester of pregnancy显示文摘	Yuen PM Ng PS Leung PL	2004	Surg Endosc2004，18，9：	1
7	Outcome in laparoscopic management of persisting adnexal mass during the second trimester of pregnancy 显示文摘	Yuen PM Ng PS Leung PL	2004	Surg Endosc2004，18，90：	1
8	Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology 显示文摘	Leung MCK Williams PL Benedetto A	2008	Toxicological Sciences2008，106，：	1
9	Outeome in laparoseopic management of persistent adnexal mass during the second trimester of pegnancy显示文摘	Yuen PM Ng Ps Leung PL et a I	2004	SurgEndosc2004，18，9：	1
10	Caenorhabditis ele-gans:an emerging model in biomedical and environmental toxi-cology显示文摘	Leung MCK Williams PL Benedetto A	2008	Toxicol Sci2008，106，1：	1
11	Caenorhabdi- tis elegans: an emerging model in biomedical and envi- ronmental toxicology 显示文摘	Leung MC Williams PL Benedetto A	2008	Toxicol Sci2008，106，1：	1
12	Outcome in laparoscopic management of persistent adnexal mass during the second trimester of pregnancy显示文摘	Yuen PM Ng PS Leung PL	2004	Surg Endosc2004，18，9：	1
13	Analysis of incidence of childhood cancer in the west midlands of the united Kingdom in relation to proximity to main roads and petrol stations 显示文摘	Harrison RM Leung PL Somervaille L	1999	Occup Environ Med1999，56，：	1
14	An audit on hysterectomy for benign diseases in public hospitals in Hong Kong显示文摘	Leung PL Tsang SW Yuen PM	2007	Hong Kong Med J2007，13，3：	1
15	Hysteroscopic appearance of the endometrial cavity following thermal balloon endometrial ablation 显示文摘	Leung PL Tam WH Yuen PM	2003	Fertil Steril2003，79，5：	1
16	Outcome in laparescopic management ofpersistent adnexalmass during the second trimester Of pregnancy显示文摘	Yuen PM Leung PL	2004	Surg Endosc2004，18，9：	1
17	Outcome in laparoscopic management of persistent adnexal mass during the second trimester of pregnancy显示文摘	Yuen PM Ng PS Leung PL	2004	SurgEndose2004，18，9：	1
18	Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Esche- richia coli isolates显示文摘	Ho PL Leung LM Chow KH	2014	J Microbiol Immunol Infect2014，14，：	1
19	Posttraumatic growth in coronary artery disease outpatients:Relationship to degree of trauma and health service use 显示文摘	Leung YW Alter DA Prior PL	2012	Journal of Psychoso- matic Research2012，72，4：	1
20	Deep vein thrombosis and pulmonary embolism in the Chinese population显示文摘	Nandi PL Li WS Leung R	1998	Hong Kong Med J1998，4，3：	1

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