2篇
您的检索式：作者名="Lexiang Yu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | D-ribose increases triglyceride via upregulation of DGAT in the liver显示文摘Dear Editor, Fatty liver disease or hepatic steatosis, recognized as the hepatic component of metabolic syndrome, can progress to cirrhosis and hepatocellular carcinoma (Youngwanichsetha, 2018). | Yao Chen Lexiang Yu Yan Wei Yang Long Yong Xu Tao He Rongqiao He | 2019 | Science China(Life Sciences)2019，62，6： | 9 |
| 2 | Acetylation of PPARγin macrophages promotes visceral fat degeneration in obesity显示文摘Obesity is characterized by chronic,low-grade inflammation,which is driven by macrophage infiltration of adipose tissue.PPARγ is well established to have an anti-inflammatory function in macrophages,but the mechanism that regulates its function in these cells remains to be fully elucidated.PPARγundergoes post-translational modifications(PTMs),including acetylation,to mediate ligand responses,including on metabolic functions.Here,we report that PPARγacetylation in macrophages promotes their infiltration into adipose tissue,exacerbating metabolic dysregulation.We generated a mouse line that expresses a macrophage-specific,constitutive acetylation-mimetic form of PPARγ(K293Q^(flox/flox):LysM-cre,mK293Q)to dissect the role of PPARγacetylation in macrophages.Upon highfat diet feeding to stimulate macrophage infiltration into adipose tissue,we assessed the overall metabolic profile and tissue-specific phenotype of the mutant mice,including responses to the PPARγagonist Rosiglitazone.Macrophage-specific PPARγK293Q expression promotes proinflammatory macrophage infiltration and fibrosis in epididymal white adipose tissue,but not in subcutaneous or brown adipose tissue,leading to decreased energy expenditure,insulin sensitivity,glucose tolerance,and adipose tissue function.Furthermore,mK293Q mice are resistant to Rosiglitazone-induced improvements in adipose tissue remodeling.Our study reveals that acetylation is a new layer of PPARγregulation in macrophage activation,and highlights the importance and potential therapeutic implications of such PTMs in regulating metabolism. | Nicole Aaron Tarik Zahr Ying He Lexiang Yu Brent Mayfield Utpal BPajvani Li Qiang | 2022 | Life Metabolism2022，1，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员