|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Association between PCR-RFLP Polymorphisms of Five Gene Loci and Milk Traits in Chinese Holstein显示文摘 | Zhang R F Chen H Lei C Z | 2007 | Asian-Aust J Anim Sei2007，20，2： | 1 |
| 3 | The Ag-BiOBrx composite photocatalyst;preparation,character-ization and their novel pollutants removal property显示文摘 | Lei Y Q Wang G H Guo P R | 2013 | Applied Surface Science2013，279，： | 1 |
| 4 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 5 | Low-temperature NH3-SCR of NO by lanthanum manganite perovskites: Effect of A-/B-site substitution and TiO2/CeO2 support显示文摘 | ZHANG R D YANG W LUO N LI P LEI Z G CHEN B H | 2014 | Appl Catal B: Environ2014，146，： | 1 |
| 6 | A study on the cycling stability of the Ti-V-based hydrogen storage electrode alloys 显示文摘 | PAN H ZHU Y GAO M LIU Y LI R LEI Y WANG Q | 2004 | J Alloys Compd2004，364，12： | 1 |
| 7 | Thermolumine- scence and temperature-dependent afterglow properties in BaSi202N2 : Eu2+ 显示文摘 | Qin J L Zhang H R Lei B F | 2013 | Journal of the American Ceramic Society2013，96，10： | 1 |
| 8 | Direct electron transfer of glucose oxidase on carbon nanotubos显示文摘 | Guiseppi-Elie A Lei C H Bauglunan R H | 2002 | Nanotechnology2002，13，： | 1 |
| 9 | Anovel nonlinear otically ac- tive tubular coordination network based on two distinct ho- mo-ehiral helices 显示文摘 | Lei H Hong M Wang R | 2003 | Chemical Communications2003，20，20： | 1 |
| 10 | Preparation of SrSi2 02 N+ : Eu2+ phosphor by SrSi alloy precursor and its long-lasting phosphorescence properties 显示文摘 | Zhang H R Lei B F Qin J L | 2013 | Jour- nal of the American Ceramic Society2013，96，6： | 1 |
| 11 | A novel structural design of CNx-Fe3 O4 as support to immobilize Pd for catalytic oxidation of formic acid显示文摘 | JIA J WANG R WANG H JI S KEY J LINKOV V SHI K LEI Z | 2011 | Catal Commun2011，16，1： | 1 |
| 12 | Regulatory link between DNA methylation and active demethylation in Arabidopsis显示文摘 | LEI M G ZHANG H M JULIAN R | 2015 | Proceedings of the national academy of sciences of the United States of America2015，112，11： | 1 |
| 13 | SME- Arrhenius model for WSI of rice flour in a twin- screw extruder显示文摘 | Lei H Fulcher R G Ruan R | 2005 | Cereal Chem2005，82，5： | 1 |
| 14 | Mechanical spectroscopy of polymer :nagnelile composites 显示文摘 | Bernd W Werner R Lei Q H | 2004 | Materials Science and Engineering A2004，370，12： | 1 |
| 15 | Rat amnion type Ⅳ collagen composition and metabolism: implications for membrane breakdown 显示文摘 | Lei H Kalluri R Furth E E | 1999 | Biol Reprod1999，60，1： | 1 |
| 16 | Integrated metabolomic analysis of the nano-sized copper particle induced hepatotoxieity and nephrotoxicity in rats: A rapid in vivo screening method for nanotoxicity 显示文摘 | Lei R H Wu C Q Yang B H | 2008 | Toxicol Appl Pharmacol2008，232，2： | 1 |
| 17 | 查看详情显示文摘 | Hu G Y Zhang J Y Zheng J Shen B F Liu S Y Yang J M Ding Y K Hu X Huang Y X Du H B Yi R Q Lei A L Xu Z Z | | 0，，： | 1 |
| 18 | Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection 显示文摘 | Lei R X Shi H Peng X M | 2009 | Hepatology2009，50，3： | 1 |
| 19 | Association between polymor- phisms of MST1V and MYF5 genes and growth traits in three Chinese cattle breeds, Asian - Australas 显示文摘 | Zhang R F Cben H Lei C Z | 2007 | Anita Sei2007，20，： | 1 |
| 20 | 查看详情显示文摘 | Hu G Y Zheng J Shen B F Lei A L Liu S Y Zhang J Y Yang J M Ding Y K Hu X Huang Y X Du H B Yi R Q Xu Z Z | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员