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| 1 | Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice显示文摘 | Shi-Jiang Lu Feng Li Hong Yin Qiang Feng Erin A Kimbrel Eunsil Hahm Jonathan N Thon Wei Wang Joseph E ltaliano Jaehyung Cho Robert Lanza | 2011 | Cell Research2011，21，3： | 14 |
| 2 | Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy显示文摘Real-time vibrational spectroscopic imaging is desired for monitoring cellular states and cellular processes in a label-free manner.Raman spectroscopic imaging of highly dynamic systems is inhibited by relatively slow spectral acquisition on millisecond to second scale.Here,we report microsecond scale vibrational spectroscopic imaging by lock-in free parallel detection of spectrally dispersed stimulated Raman scattering signal.Using a homebuilt tuned amplifier array,our method enables Raman spectral acquisition,within the window defined by the broadband pulse,at the speed of 32 μs and with close to shot-noise limited detection sensitivity.Incorporated with multivariate curve resolution analysis,our platform allows compositional mapping of lipid droplets in single live cells,observation of intracellular retinoid metabolism,discrimination of fat droplets from protein-rich organelles in Caenorhabditis elegans,spectral detection of fast flowing tumor cells and monitoring drug diffusion through skin tissue in vivo.The reported technique opens new opportunities for compositional analysis of cellular compartment in a microscope setting and high-throughput spectral profiling of single cells in a flow cytometer setting. | Chien-Sheng Liao Mikhail N Slipchenko Ping Wang Junjie Li Seung-Young Lee Robert A Oglesbee Ji-Xin Cheng | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 3 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 4 | On crack development in graphite-epoxy s laminates under uniaxial tension 显示文摘 | Wang A S D Kirshore N N Li C A | 1985 | Comp Sci Technol1985，23，： | 2 |
| 5 | Development and characterization of monoclonal antibody specific to nuclear protein of avian influenza virus type A 显示文摘 | LI N QIN A J SHAO H X | 2008 | Agricuhural Science & Technology2008，9，1： | 1 |
| 6 | Studies on the micropolarities of /TX-100/toluene ionic liquid microemulsions andtheir behaviors characterized by UV - visible spectroscopy 显示文摘 | Li N Gao Y A Zheng L Q | 2007 | Langmuir2007，23，： | 1 |
| 7 | Gene expression levels in normal human lymphablasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility显示文摘 | KOMISSAROVA E V LI P UDDIN A N | 2008 | Toxicol Appl Pharmaco12008，226，2： | 1 |
| 8 | An improved rice transformation system using the biolistic method显示文摘 | Li L C Qu R D de Kochko A Fauquet C Beachy R N | 1993 | PlantCell Rep1993，12，： | 1 |
| 9 | Physics and materials challenges for lead-free solders 显示文摘 | Tu K N Gusak A M Li M | 2003 | Journal of Applied Physics2003，93，3： | 1 |
| 10 | Pare:a eytoplasmie anchor for p53显示文摘 | Nikolaev A Y Li M Puskas N | 2003 | Cell2003，112，1： | 1 |
| 11 | Research advances in dry anaerobic digestion process of solid organic wastes 显示文摘 | JHA A K LI J LORING N | 2011 | Africa Journal of Biotechnology2011，10，14： | 1 |
| 12 | Characteriza-tion of Products Recycling from PCB Waste Pyrolysis显示文摘 | QUAN C LI A M GAO N B | 2010 | Journal of Analytical and Applied Pyrolysis2010，89，： | 1 |
| 13 | Inhibition of autophagy augments 5-fluorouracil chemo- therapy in human colon cancer in vitro and in vivo model 显示文摘 | Li J Hou N Faried A | 2010 | Eur J Cancer2010，46，10： | 1 |
| 14 | Carbon dioxide solubility in some ionic liquids at moderate pressures显示文摘 | SORIANO A N DOMA B T LI M | 2009 | Journal of the Taiwan Institute of Chemical Engineers2009，40，4： | 1 |
| 15 | Potential magnesium alloys for high temperature die cast automotive applications: a review 显示文摘 | Hu H Yu A Li N | 2003 | Materials and ManufacturingProcesses2003，18，5： | 1 |
| 16 | Bioconversion of dairy manure by black soldier fly (Diptera:Stratiomyidae) for biodiesel and sugar production显示文摘 | Li Q Zheng L Qiu N et a/ | 2011 | Waste Management2011，31，： | 1 |
| 17 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 18 | Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia 显示文摘 | Li Y Chu N Hu A | 2007 | Brain2007，130，2： | 1 |
| 19 | Activation of the nicotinic acetylcholine receptor involves a switch in conformarion of the subunits显示文摘 | UNWIN N MIYAZAWA A LI J | 2002 | J Mol Biol2002，319，： | 1 |
| 20 | Diameter-selective encapsulation of metallocenes in single walled carbon nanotubes 显示文摘 | Li L J Khlobystov A N Wiltshire J G Briggs G A D Nicholas R J | 2005 | Nature Materials2005，4，： | 1 |
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