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| 1 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 2 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 3 | Personalized targeted therapy for esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial. | Xiaozheng Kang Keneng Chen Yicheng Li Jianying Li Thomas A D'Amico Xiaoxin Chen | 2015 | World Journal of Gastroenterology2015，21，25： | 10 |
| 4 | Trogocytosis of CD80 and CD86 by induced regulatory 7 cells显示文摘 | Peng Gu Julia Fang Gao Cheryl A D'Souza Aleksandra Kowalczyk Kuang-Yen Chou Li Zhang | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 5 | 儿童型囊性肾瘤在形态学、免疫表型和基因遗传学方面与成人型囊性肾瘤不同显示文摘传统意义上的囊性肾瘤包括两种肿瘤,一种是成人型囊性肾瘤,属于混合性上皮间质肿瘤(MEST)谱系的一部分;另一种是儿童型囊性肾瘤,与DICER1基因突变相关。目前,尚无有关该肿瘤两种病变在形态学、免疫表型和基因遗传学方面详细的对比性分析。 | Li Y Pawel B R Hill D A 魏建国 许春伟 | 2017 | 临床与实验病理学杂志2017，33，5： | 6 |
| 6 | Endophytic bacteria associated with endangered plant Ferula sinkiangensis K. M. Shen in an arid land: diversity and plant growth-promoting traits显示文摘Ferula spp. are traditional medicinal plants found in arid land. Large-scale excavation for extracting bioactive compounds from the plants in arid regions of Xinjiang over the last few years has, however, significantly decreased their distributions. Due to the urgent need for preservation of these plant resources, along with the need of searching for alternative source of the useful metabolites, it is important to screen the endophytic microbial resources associated with the plant Ferula sinkiangensis K. M. Shen. In the study, a total of 125 endophytic bacteria belonging to 3 phyla, 13 orders, 23 families, and 29 genera were isolated based on 16 SrRNA gene sequencing data. Among the different isolates, three strains isolated from roots were potential novel species of the genera Por phyrobacter, Paracoccus and Amycolatopsis. In this study, 79.4% and 57.1% of the total isolates were capable of producing indole-3-acetic acid(IAA) and siderophore, respectively. And, 40.6% of the strains inhibit the growth of fungal pathogen Alternaria alternata, 17.2% and 20.2% strains were positive for antagonism against Verticillium dahlia 991 and V. dahlia 7, respectively. These results demonstrated that F. sinkiangensis is a rich reservoir of endophytic bacterial resources with potential for production of biologically important functions such as plant growth-promoting factors. | LIU Yonghong GUO Jianwei LI Li Mipeshwaree D ASEM ZHANG Yongguang Osama A MOHAMAD Nimaichand SALAM LI Wenjun | 2017 | Journal of Arid Land2017，9，3： | 6 |
| 7 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 8 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 9 | Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation显示文摘B″蛋白质磷酸酶 2A (PP2A ) 的 /PR72 家庭一个重要 PP2A 家庭涉及多样的细胞的过程,并且特别地由钙绑定调整了到规章的子单元。在这个家庭的 PR70 子单元与房间部门控制 6 交往(Cdc6 ) ,为 DNA 复制的控制重要的一个房间周期管理者。这里,我们在 2.1 和 2.4 Å 的一个决定报导孤立的 PR72 和 trimeric PR70 holoenzyme 的水晶结构;,分别地并且在 Cdc6 dephosphorylation 的 vitro 描述。holoenzyme 结构表明 PR70 钙绑定主题之一直接联系支架子单元,导致在所有 PP2A holoenzymes 之中的最紧缩的支架子单元符合构造。PR70 也在活跃地点附近区别地绑在催化子单元,它被要求让 PR70 向 Cdc6 提高磷酸酶活动。我们的研究为 B″ 的唯一的规定提供一个结构的基础;由钙离子的 /PR72 holoenzymes,并且在 PP2A holoenzymes 之中为底层特性的精确控制建议机制。 | Nathan Wlodarchak Feng Guo Kenneth A Satyshur Li Jiang Philip D Jeffrey Tingwan Sun Vitali Stanevich Marc C Mumby Yongna Xing | 2013 | Cell Research2013，23，7： | 3 |
| 10 | On crack development in graphite-epoxy s laminates under uniaxial tension 显示文摘 | Wang A S D Kirshore N N Li C A | 1985 | Comp Sci Technol1985，23，： | 2 |
| 11 | Antifungal evaluation of pseudolaric acid B, a major constituent of pseudolarix kaempferi显示文摘 | Li E Clark A M Hufford C D | 1995 | J Nat Prod1995，58，： | 1 |
| 12 | Expression profile of the channel catfish spleen: analysis of genes involved in immune functions显示文摘 | Kocabas A M Li P Cao D | 2002 | Mar Biotechnol2002，4，： | 1 |
| 13 | Development of the East Asian mon- soon: Mineralogical and sedimentologic records in the northern South China Sea since 20 Ma 显示文摘 | Wan S Li A Clift P D | 2007 | Palaeogeography Palaeoclimatology Palaeoecology2007，254，： | 1 |
| 14 | A large metabolic carbon contribution to the delta^13C record in marine aragonitic bivalve shells 显示文摘 | Gillikin D P Lorrain A Li M | 2007 | Geochimicaet CosmochimicaActa2007，71，12： | 1 |
| 15 | An improved rice transformation system using the biolistic method显示文摘 | Li L C Qu R D de Kochko A Fauquet C Beachy R N | 1993 | PlantCell Rep1993，12，： | 1 |
| 16 | Computational prediction of novel components of lung transcription networks 显示文摘 | Martinez M J Smith A D Li B L | 2007 | Bioinformatics2007，23，1： | 1 |
| 17 | Up-regulation of heat shock proteins is essential for cold survival during insect diapause 显示文摘 | Rinehart J P Li A Yocum G D | 2007 | Proceedings of the National Academy of Sci- ences2007，104，11： | 1 |
| 18 | An evaluation of failure criteria for ma- trix induced failure in composite materials显示文摘 | Li R Kelly D Crosky A | 2002 | Composite Struc- tures2002，57，1： | 1 |
| 19 | Genome shuffling of Streptomyces viridochromogenes for improved produc- tion of avilamyein显示文摘 | Lv X A Jin Y Y Li Y D etal | 2013 | Applied Microbiology and Bio- technology2013，97，2： | 1 |
| 20 | Lidar DEM Error Analyses and Topographic Depression Identifi- cation in a Hummocky Landscape in the Prairie Region of Canada 显示文摘 | LI Sheng MACMILLAN R A LOBB D A | 2011 | Geomorphology2011，129，3： | 1 |
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