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| 1 | Doxycycline-regulated co-expression of GDNF and TH in PC12 cells.显示文摘 | Wang JJ Zhang T Niu DB Wang K Li KR Xue B Wang XM | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 2 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013，10，6： | 10 |
| 3 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 4 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 5 | Multisensor image fusion using the wavelet transform 显示文摘 | LI H MANJUNATH B S MITRA S K | 1995 | Graph Models Image Process1995，57，3： | 1 |
| 6 | Dynamic testing at high strain rates of an ultrafine-grained magnesium alloy processed by ECAP 显示文摘 | Li B Joshi S Azevedoa K | 2009 | Mater Sci Eng A2009，517，2429： | 1 |
| 7 | 显示文摘 | Cao Z K Li B Yao G C | 2008 | Mater Sci Eng A2008，486，： | 1 |
| 8 | Power density distribution simulation and relevant heat effect calculation of a high-power CO2 laser with low order modes显示文摘 | MA K FAN Z B | 2002 | Chinese Journal of Laser2002，11，5： | 1 |
| 9 | Silicon quantum-wires arrays synthesized by chemical vapor deposition and its icrostructural properties显示文摘 | LU M LI M K KONG L B | 2003 | Chemical Physics Letters2003，374，： | 1 |
| 10 | Spatial and temporal patterns of soil organic matter in the urban-rural transition zone of Beijing显示文摘 | HU K LI H L | 2007 | Geoderma2007，141，34： | 1 |
| 11 | Energetics of charged point defects in rutile TiO2 by density functional theory显示文摘 | LI X FINNIS M W HE J BEHERA R K PHILLPOT S R SINNOTT S B DICKEY E C | 2009 | Acta Materialia2009，57，： | 1 |
| 12 | Hydrogen production fromdiluted molasses by anaerobic hydrogen producing bacteria in ananaerobic baffled reactor(ABR)显示文摘 | Li J Z Li B K Zhu G F | 2007 | International Journal ofHydrogen Energy2007，32，15： | 1 |
| 13 | Structured databases on the Web : Observations and implications 显示文摘 | Chang K C He B Li C | 2004 | ACM SIG- MOD Record2004，35，3： | 1 |
| 14 | High Precision Large Deflection Measurements of Thin Films Using Time Sequence Speckle Pattern Interferormetry显示文摘 | Li X Soh A K Deng B | 2002 | Measurement Science and Technology2002，13，8： | 1 |
| 15 | Transcrystalline morphology of an in situ microfibrillar poly(ethylene terephthalate)/poly(propylene) blend fabricated through a slit extrusion hot stretching-quenching process 显示文摘 | Li Z M Li L B Shen K Z | 2004 | Macromolecular Rapid Communications2004，25，3： | 1 |
| 16 | Effect of interdiffusion on the subbands in an Alx Ga1-xAs single quantum-well structure显示文摘 | Li E H Weiss B L Chan K S | 1992 | Phys Rev B1992，46，15： | 1 |
| 17 | Robust fixture configuration design for sheet metal assembly with laser welding显示文摘 | Li Bing Shiu B W Lau K J | 2003 | Journal of Manufacturing Science and Engineering2003，125，1： | 1 |
| 18 | A dynamic call admission policy with precision QoS guarantee using stochastic control for mobile wireless networks显示文摘 | S Wu K Y M Wong B Li | 2002 | IEEE/ACM Transactions on Networking2002，10，2： | 1 |
| 19 | Mixed mode fatigue crack growth criteria显示文摘 | Ai K S Li C B | 2001 | International Journal of Fatigue2001，23，5： | 1 |
| 20 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
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