|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tissue specificity of DNA damage response and tumorigenesis显示文摘The genome of cells is constantly challenged by DNA damages from endogenous metabolism and environmental agents.These damages could potentially lead to genomic instability and thus to tumorigenesis.To cope with the threats, cells have evolved an intricate network, namely DNA damage response(DDR) system that senses and deals with the lesions of DNA.Although the DDR operates by relatively uniform principles, different tissues give rise to distinct types of DNA damages combined with high diversity of microenvironments across tissues.In this review, we discuss recent findings on specific DNA damage among different tissues as well as the main DNA repair way in corresponding microenvironments, highlighting tissue specificity of DDR and tumorigenesis.We hope the current review will provide further insights into molecular process of tumorigenesis and generate new strategies for cancer treatment. | Siman Sun Michael DOsterman Mo Li | 2019 | Cancer Biology & Medicine2019，16，3： | 3 |
| 2 | 40 cases of hypospadias treatment显示文摘 | Chen Yongsheng Li Siman Peng Mingdong | 2014 | Joumal of Kunming Medical University2014，35，2： | 1 |
| 3 | Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities显示文摘Efficient oral delivery of drugs treating brain diseases has long been a challenging topic faced by the drug delivery community. Fortunately, polyester nanoparticles offer certain solutions to this problem. This review article firstly describes the main obstacles faced by oral administered brain targeting, including:(1)instability in the gastrointestinal tract;(2) poor penetration of the intestinal mucosa and epithelium;(3)blood clearance;and(4) restriction by the BBB. Then the key factors influencing brain-targeting efficiency of orally administered polyester nanoparticles are also discussed, such as size, shape and surface properties. Finally, recent brain-targeting delivery strategies using oral polyester nanoparticles as carriers and their effects on brain drugs transport are reviewed, and the delivery ‘as a whole’ strategy of polyester nanoparticles will provide new insight for oral brain-targeting delivery. And by combination of multiple strategies, both the stability and permeability of polyester nanoparticles can be greatly improved for oral brain drug delivery. | Ping Wang Yue Wang Ping Li Chen Chen Siman Ma Linxuan Zhao Haibing He Tian Yin Yu Zhang Xing Tang Jingxin Gou | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员