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| 1 | Synthesis and Structure of A Novel Caged Bicyclic Phosphate Flame Retardant显示文摘A novel caged bicyclic phosphate flame retardant tri(1-oxo-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane-methyl) phosphate (Trimer) was synthesized from 1-oxo-4-hydroxymethyl-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane (PEPA) and phosphorus oxychloride in this paper. Its structure was characterized by elemental analysis, FTIR, 1H NMR, 31P NMR and X-ray diffraction analysis. | Li, X Ou, YX Zhang, YH Lian, DJ | 2000 | Chinese Chemical Letters2000，11，10： | 28 |
| 2 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 3 | Bioactive asterosaponins from the starfish Culcita novaeguineae显示文摘 | Tang HF Yi YH Li L Sun P Zhang SQ Zhao YP | 2005 | 第二军医大学学报2005，26，8： | 5 |
| 4 | Relationship between polymetallic nodules and submarine hydrothermalism in the Central Pacific Ocean显示文摘THE huge reserves of submarine polymetallic nodules make them an important kind of potentialmineral resources. It has already been discovered that polymetallic nodules are related withsubmarine vollcanogene hydrothermalism. For example, pyroclasts usually occur as coresubstances of the nodules, and large amounts of mineralizing materials such as manganese aredischarged to form ferromanganese oxides along with the submarine vocanogene hydrothermal- | Li, YH Song, HB Li, JC Yao, XM | 1997 | Chinese Science Bulletin1997，42，23： | 4 |
| 5 | Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes: A cross-sectional study显示文摘 | Fan XH Wu QH Li Y Hao YH Ning N Kang Z Cui Y Liu RH | 2014 | Chinese Medical Journal2014，，4： | 4 |
| 6 | Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘 | Pan W Quarles LD Song LH Yu YH Jiao C Tang HB Jiang CH Deng HW Li YJ Zhou HH Xiao ZS | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 7 | Molecular diversity of microbial community in acid mine drainages of Yunfu sulfide mine显示文摘 | He ZG Xiao SM Xie XH Zhong H Hu YH Li QH Gao FL Li GY Liu JS Qiu GZ | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 8 | Ureaplasma urealyticum induced production proinflammatory cytokines by macrophages 显示文摘 | Li yh Brauner A Jonsson B | 2000 | Pediatr Res2000，48，1： | 1 |
| 9 | Medical Conditions Treated by Acupuncture: A Preliminary Review of Randomized Controlled Trials显示文摘 | Du YH Xiong J Li B | 2009 | Medical Acupuncture2009，21，3： | 1 |
| 10 | Functional mutation in the promoter region of thrombomodulin gene in relation to carotid atherosclerosis 显示文摘 | Li YH Chen CH Yeh PS | 2001 | Atherosclerosis2001，154，1： | 1 |
| 11 | Phacoemulsification treatment of subjects with acute primary angle closure and chronic primary angle-closure glaucoma 显示文摘 | Zhuo YH Wang M Li Y | 2009 | J Glaucoma2009，18，9： | 1 |
| 12 | Endotoxin-induced alterations in insulin-stimulated phsophorylation of insulin receptor, IRS-1, and MAP kinase in skeletal muscle 显示文摘 | Fan J Li YH Wojnar MM | 1996 | Shock1996，6，： | 1 |
| 13 | Determination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection显示文摘 | Li YH Wang CY Sun JY | 2005 | Analytica Chimica Acta2005，550，12： | 1 |
| 14 | A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma 显示文摘 | Lan YH Li YG Liang ZW | 2007 | Cancer Immunol Immunother2007，56，7： | 1 |
| 15 | Control of three-phase boost-type PWM rectifier in stationary frame under unbalanced input voltage显示文摘 | Li Z X Li YH Wang P | 2010 | IEEE Transactions on Industrial Electronics2010，25，10： | 1 |
| 16 | Effect of diet and exercise in preventing NIDDM in people with impaired glucose tolerance显示文摘 | Pan XR Li GW Hu YH | 1997 | Diabetes Care1997，20，： | 1 |
| 17 | Modified technique of radical inguinal lymphadenectomy for penile carcinoma: morbidity and outcome 显示文摘 | Yao K Tu H Li YH | 2010 | J Urol2010，184，2： | 1 |
| 18 | Reduced brain edema and ma- trix metalloproteinase (MMP) expression by pre-reperfution in- fusion into ischemic territory, in rat 显示文摘 | Ding YH Li J Rafols JA | 2004 | Neurosci Lett2004，372，12： | 1 |
| 19 | MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia显示文摘 | Gao XN Lin J Li YH | 2011 | Oncogene2011，30，31： | 1 |
| 20 | Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy显示文摘 | Tan XY Li YJ Liu YH | | 0，，10： | 1 |
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