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| 1 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 2 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 3 | Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue,and its possible role in tumor immunity显示文摘AIM:To investigate the expression of 4-1BB molecule in hepatocellular carcinoma (HCC) and its adjacent tissues.METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the gene expression of 4-1BB in hepatocarcinoma and its adjacent tissues,and peripheral blood mononuclear cells (PBMCs) from both HCC and health control groups.Flow cytometry was used to analyse the phenotypes of T cell subsets from the blood of HCC patients and healthy volunteers,and further to determine whether 4-1BB molecules were also expressed on the surface of CD4+ and CD8+ T cells. The localization of 4-1BB proteins on tumor infiltrating T cells was determined by direct immunofluorescence cytochemical staining and detected by confocal microscopy.RESULTS:4-1BB mRNA, which was not detectable in normal liver,was found in 19 liver tissues adjacent to tumor edge(<1.0cm).Low expression of 4-1BB mRNA was shown in 8 tumor tissues and 6 liver tissues located within 1 to 5cm away from tumor edge. In PBMCs, 4-1BB mRNA was almost not detected. Percentage of CD4^+, CD8^+ and CD3^+/CD25^+ T cells, as well as ratio of CD4 to CD8 revealed no difference between groups (P>0.05,respectively),while a significant lower percentage of CD3^+ T cell was found in HCC group as compared to healthy control group (P<0.05).However, 4-1BB molecules were almost not found on the surface of CD4+ and CD8+ T cells in HCC and healthy control group.Double-staining of 4-1BB^+/CD4^+ and 4-1BB^+/CD8^+ immunofluorescence on tumor infiltrating T cells was detected in 13 liver tissues adjacent to tumor edge (<1.0cm) by confocal microscopy.CONCLUSION: Although HCC may escape from immune attack by weak immunogenicity or downregulated expression of MHC-1 molecules on the tumor cell surface,tumor infiltrating T cells can be activated via other costimulatory signal pathways to exert a limited antitumor effect on local microenvironment. The present study also implicates that modulating 4-1BB/4-1BBL costimulatory pathway may be an effective immunotherapy strategy to augment the host response. | Wan, YL Zheng, SS Zhao, ZC Li, MW Jia, CK Zhang, H | 2004 | World Journal of Gastroenterology2004，10，2： | 6 |
| 4 | Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats显示文摘 | Zhao,ZM Li,HJ Liu,HY Lu,SH Yang,RC Zhang,QJ Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 5 | Effects of nitrogen fertiliser and wheat straw application on CH4 and N20 emissions from a paddy rice field显示文摘 | Ma J Li XL Xu H Han Y Cai ZC Yagi K | 2007 | Australian Journal of Soil Research2007，45，： | 1 |
| 6 | Supine lithotomy venus prone position in minimally invasive percutaneous nephrolithotomy for upper urinary tract calculi显示文摘 | Zhan HL Li ZC Zhou XF | 2013 | Urol Int2013，91，3： | 1 |
| 7 | Increased plasma C-reactive protein and interleukin 6 concentrations in patients with slow coronary flow显示文摘 | Li J J Qin XW Li ZC | 2007 | Clin Chim Acta2007，385，： | 1 |
| 8 | Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow 显示文摘 | LI JJ QIN XW LI ZC | 2007 | Clin Chim Acta2007，385，12： | 1 |
| 9 | Micro-CT and mechani-cal evaluation of subchondral trabecular bone structure be-tween postmenopausal women with osteoarthritis and oste-oporosis 显示文摘 | Zhang ZM Li ZC Jiang LS | 2010 | Osteoporos Int2010，21，8： | 1 |
| 10 | Abnormal immunity and stern/progenitor- cells in acquired aplastic anenlia显示文摘 | Li JP Zheng CL Han ZC | 2010 | Crit Rev Oncol Hemato12010，75，2： | 1 |
| 11 | Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma显示文摘 | Zhang ZC Li YY Wang HY | 2014 | PLoS One2014，9，86： | 1 |
| 12 | Abnormal immunity and stem/progenitor cells in acquired aplastic anemia显示文摘 | Li JP Zheng CL Han ZC | | 0，，02： | 1 |
| 13 | Platelet factor 4 and other CXC chemokines support the survival of normal hematopoietic cells and reduce the chemosensitivity of cells to cytotoxic agents显示文摘 | Han ZC Lu I Li J | 1997 | Blood1997，89，7： | 1 |
| 14 | Micrc-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis 显示文摘 | Zhang ZM Li ZC Jiang LS | 2010 | Osteoporos Int2010，21，8： | 1 |
| 15 | Icariin promotes directed ehondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro 显示文摘 | Wang ZC Sun HJ Li KH et a/ | 2014 | Exp Ther Med2014，8，5： | 1 |
| 16 | Is slow coronary flow associated with inflammation 显示文摘 | Li JJ Xu B Li ZC | 2006 | Med Hypotheses2006，66，3： | 1 |
| 17 | FAK expression regulation and therapeutic potential显示文摘 | Li S Hua ZC | 2008 | Adv Cancer Res2008，101，1： | 1 |
| 18 | Prediction of soil organic matter in peak-cluster depression region using kriging and terrain indices显示文摘 | Yang QY Jiang ZC Li WJ Li H | 2014 | Soil and Tillage Research2014，144，： | 1 |
| 19 | Roles of some inflammatory mediatots in the pathogenesis of early pulmonary edema in steam respiratory bums 显示文摘 | Li Ao Jiang KY Yang ZC | 1987 | Chin ned J (Engl)1987，100，2： | 1 |
| 20 | Platelet factor 4 and other CXC chemkines support the survival of normal hematopoietic cells and reduce the chemo-sensitivity of cells to cytotoxic agents 显示文摘 | Han ZC Lu M Li J | 1997 | Blood1997，89，7： | 1 |
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