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您的检索式：作者名="Liangfeng Liu"
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| 1 | A heteropore covalent organic framework for adsorptive removal of Cd(Ⅱ) from aqueous solutions with high efficiency显示文摘A heteropore covalent organic framework(COF) integrating tetraphenylethene skeleton and catechol segment is designed and synthesized.It exhibits extremely high stability in water under different pH conditions,which makes it an excellent material for adsorptive removal of Cd(Ⅱ) from aqueous solutions with very fast adsorption kinetics,high uptake capacity,and good recyclability. | Na Liu Liangfeng Shi Xianghao Han Qiao-Yan Qi Zong-Quan Wu Xin Zhao | 2020 | Chinese Chemical Letters2020，31，2： | 6 |
| 2 | Disassemblability Modeling Technology of Configurable Product Based on Disassembly Constraint Relation Weighted Design Structure Matrix(DSM)显示文摘The current research of configurable product disassemblability focuses on disassemblability evaluation and disassembly sequence planning.Little work has been done on quantitative analysis of configurable product disassemblability.The disassemblability modeling technology for configurable product based on disassembly constraint relation weighted design structure matrix(DSM)is proposed.Major factors affecting the disassemblability of configurable product are analyzed,and the disassembling degrees between components in configurable product are obtained by calculating disassembly entropies such as joint type,joint quantity,disassembly path,disassembly accessibility and material compatibility.The disassembly constraint relation weighted DSM of configurable product is constructed and configuration modules are formed by matrix decomposition and tearing operations.The disassembly constraint relation in configuration modules is strong coupling,and the disassembly constraint relation between modules is weak coupling,and the disassemblability configuration model is constructed based on configuration module.Finally,taking a hydraulic forging press as an example,the decomposed weak coupling components are used as configuration modules alone,components with a strong coupling are aggregated into configuration modules,and the disassembly sequence of components inside configuration modules is optimized by tearing operation.A disassemblability configuration model of the hydraulic forging press is constructed.By researching the disassemblability modeling technology of product configuration design based on disassembly constraint relation weighted DSM,the disassembly property in maintenance,recycling and reuse of configurable product are optimized. | QIU Lemiao LIU Xiaojian ZHANG Shuyou SUN Liangfeng | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 3 | Corynoxine B targets at HMGB1/2 to enhance autophagy forα-synuclein clearance in fly and rodent models of Parkinson's disease显示文摘Parkinson's disease(PD)is the most common neurodegenerative movement disease.It is featured by abnormal alphα-synuclein(α-syn)aggregation in dopaminergic neurons in the substantia nigra.Macroautophagy(autophagy)is an evolutionarily conserved cellular process for degradation of cellular contents,including protein aggregates,to maintain cellular homeostasis.Corynoxine B(Cory B),a natural alkaloid isolated from Uncaria rhynchophylla(Miq.)Jacks.,has been reported to promote the clearance ofα-syn in cell models by inducing autophagy.However,the molecular mechanism by which Cory B induces autophagy is not known,and theα-syn-lowering activity of Cory B has not been verified in animal models.Here,we report that Cory B enhanced the activity of Beclin 1/VPS34 complex and increased autophagy by promoting the interaction between Beclin 1 and HMGB1/2.Depletion of HMGB1/2 impaired Cory B-induced autophagy.We showed for the first time that,similar to HMGB1,HMGB2 is also required for autophagy and depletion of HMGB2 decreased autophagy levels and phosphatidylinositol 3-kinaseⅢactivity both under basal and stimulated conditions.By applying cellular thermal shift assay,surface plasmon resonance,and molecular docking,we confirmed that Cory B directly binds to HMGB1/2 near the C106 site.Furthermore,in vivo studies with a wild-typeα-syn transgenic drosophila model of PD and an A53Tα-syn transgenic mouse model of PD,Cory B enhanced autophagy,promotedα-syn clearance and improved behavioral abnormalities.Taken together,the results of this study reveal that Cory B enhances phosphatidylinositol 3-kinaseⅢactivity/autophagy by binding to HMGB1/2 and that this enhancement is neuroprotective against PD. | Qi Zhu Juxian Song Jia-Yue Chen Zhenwei Yuan Liangfeng Liu Li-Ming Xie Qiwen Liao Richard D.Ye Xiu Chen Yepiao Yan Jieqiong Tan Chris Soon Heng Tan Min Li Jia-Hong Lu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 2 |
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