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| 1 | Clinical Big Data and Deep Learning:Applications,Challenges,and Future Outlooks显示文摘The explosion of digital healthcare data has led to a surge of data-driven medical research based on machine learning. In recent years, as a powerful technique for big data, deep learning has gained a central position in machine learning circles for its great advantages in feature representation and pattern recognition. This article presents a comprehensive overview of studies that employ deep learning methods to deal with clinical data. Firstly,based on the analysis of the characteristics of clinical data, various types of clinical data(e.g., medical images,clinical notes, lab results, vital signs, and demographic informatics) are discussed and details provided of some public clinical datasets. Secondly, a brief review of common deep learning models and their characteristics is conducted. Then, considering the wide range of clinical research and the diversity of data types, several deep learning applications for clinical data are illustrated: auxiliary diagnosis, prognosis, early warning, and other tasks.Although there are challenges involved in applying deep learning techniques to clinical data, it is still worthwhile to look forward to a promising future for deep learning applications in clinical big data in the direction of precision medicine. | Ying Yu Min Li Liangliang Liu Yaohang Li Jianxin Wang | 2019 | Big Data Mining and Analytics2019，2，4： | 4 |
| 2 | Breakthrough Technologies for the Biorefining of Organic Solid and Liquid Wastes显示文摘有机固液废弃物包含大量能量、养分和水分,不应仅视其为废物。数十年来,人们一直对城市固体废物进行回收、堆制和燃烧,并从中提取能量和有价值的物质。污水的首要管理策略是治理和排放。随着技术的进步,通过新方法使利用固体废物和废水成为可能。考虑到废物特殊的化学、物理和生物性质,需要整合多种技术以使废物的能量和价值回收最大化。为此,生物炼制是完全利用废物中的能量和价值的一个合适的方法。研究证明,不可回收废弃物和生物固体可通过不同方法转化为可利用的热能、电能、燃料和化学品,并且液体废物或能帮助农作物和藻类的成长,为能量回收和食物生产提供不同的选择。本文针对有机固液废物提出新型生物炼制方案,这些废物来源于城市废料、食品和生物加工厂以及动物生产设施。四大新型突破性科技——真空辅助高温厌氧消化、扩展鱼菜共生系统、含油废物经甘油裂解制取生物柴油和微波辅助热化学转化,均可运用于生物炼制方案中,从而成功将废物转化,用以生产化学品、化肥、能量(沼气、合成气、生物柴油和生物油)、食物、饲料,得到干净的水并显著减少污染物的排放。 | Paul Chen Erik Anderson Min Addy Renchuan Zhang Yanling Cheng Peng Peng Yiwei Ma Liangliang Fan Yaning Zhang Qian Lu Shiyu Liu Nan Zhou Xiangyuan Deng Wenguang Zhou Muhammad Omar Richard Griffith Faryal Kabir Hanwu Lei Yunpu Wang Yuhuan Liu Roger Ruan | 2018 | Engineering2018，4，4： | 3 |
| 3 | Integrated multi-scheme digital modulations of spoof surface plasmon polaritons显示文摘The future wireless communications require different kinds of modulation functions to be integrated in a single intelligent device under different scenarios.Here,we propose a multi-scheme digital modulator to achieve this goal based on integrated spoof surface plasmon polaritons(SPP)in different frequency bands.By constructing switchable spoof SPP units,the propagating wave in the proposed spoof SPP waveguide can be manipulated in amplitude domain,frequency domain,and phase domain.As a proof of concept,the integrated multi-scheme digital modulator is experimentally verified to achieve at least three kinds of modulations,including amplitude shift keying,phase shift keying,and frequency shift keying,in a single digital spoof plasmonic waveguide.The simulated and measured results show that the modulator has excellent property of field confinement and is capable of frequency-domain modulation.Hence,the multi-scheme modulation property makes the proposed SPP digital modulator be an effective and reliable candidate for efficient manipulations of SPP waves and for advanced modulation technology. | Lepeng ZHANG Haochi ZHANG Min TANG Peihang HE Lingyun NIU Liangliang LIU Jiayuan LU Wenxuan TANG Junfa MAO Tiejun CUI | 2020 | Science China(Information Sciences)2020，63，10： | 2 |
| 4 | DNA-stabilized silver nanoclusters with guanine -enhanced fluo-rescence as a novel indicator for enzymatic detection of cho-lesterol 显示文摘 | DU AN Min PENG Yunlin ZHANG Liangliang | 2013 | Analytical Methods2013，5，9： | 1 |
| 5 | Electrospun perovskite nano-network for flexible, near-room temperature, environmentally friendly and ultrastable light regulation显示文摘Light regulation devices are essential for signal modulation, information encryption and energy-saving smart windows. Recently, due to their excellent stimuli-responsive properties, lead halide perovskites have shown great potential. However, the high transition temperature, irreversibility of the phase transition and toxicity of heavy metals make perovskite materials unsuitable for devices related to human activity. Herein, for the first time, a flexible perovskite nano-network is proposed and its application as a smart window is demonstrated. The perovskite-sodium alginate(SA) nano-network showed a 31.6 ℃(20% RH) transition temperature and stability over 1200 cycles. The hydrophobic surface and the “eggbox” structure formed by SA make that the lead leakage is only 2.569 ppb, which is much higher than the drinking water standard. This work provides a successful demonstration for energy-efcient buildings and inspires future nontoxic perovskite-based devices through heavy metal control. | Yongliang Li Haoxuan Sun Zhen Li Min Wang Linqi Guo Liangliang Min Fengren Cao Yeqiang Tan Liang Li | 2022 | Journal of Materials Science & Technology2022，，35： | 0 |
| 6 | A unique photosystem I reaction center from a chlorophyll d-containing cyanobacterium Acaryochloris marina显示文摘Photosystem I(PSI)is a large protein supercomplex that catalyzes the light-dependent oxidation of plastocyanin(or cytochrome c6)and the reduction of ferredoxin.This catalytic reaction is realized by a transmembrane electron transfer chain consisting of primary electron donor(a special chlorophyll(Chl)pair)and electron acceptors A_(0),A_(1),and three Fe_(4)S_(4) clusters,F_(X),F_(A),and F_(B).Here we report the PSI structure from a Chl d-dominated cyanobacterium Acaryochloris marina at 3.3Åresolution obtained by single-particle cryo-electron microscopy.The A.marina PSI exists as a trimer with three identical monomers.Surprisingly,the structure reveals a unique composition of electron transfer chain in which the primary electron acceptor A_(0) is composed of two pheophytin a rather than Chl a found in any other well-known PSI structures.A novel subunit Psa27 is observed in the A.marina PSI structure.In addition,77 Chls,13α-carotenes,two phylloquinones,three Fe-S clusters,two phosphatidyl glycerols,and one monogalactosyl-diglyceride were identified in each PSI monomer.Our results provide a structural basis for deciphering the mechanism of photosynthesis in a PSI complex with Chl d as the dominating pigments and absorbing far-red light. | Caihuang Xu Qingjun Zhu Jing-Hua Chen Liangliang Shen Xiaohan Yi Zihui Huang Wenda Wang Min Chen Tingyun Kuang Jian-Ren Shen Xing Zhang Guangye Han | 2021 | Journal of Integrative Plant Biology2021，63，10： | 0 |
| 7 | Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways显示文摘Fractures have an extraordinarily negative impact on individuals'quality of life and functional status.Nonunion or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new bone.The use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion. | Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu | 2024 | Genes & Diseases2024，11，1： | 0 |
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