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2篇 您的检索式：作者名="Lianwan Chen"

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		题名	作者	年代	出处	被引量
	1	The glial actin cytoskeleton regulates neuronal ciliogenesis显示文摘	Hao Zhu Lianwan Chen Yihong Yang Zhiwen Zhu Xianliang Zhang Wei Li Long Miao Yan Zhang Guangshuo Ou	2017	Cell Research2017，27，3：	1
	2	Cytosolic Ca^(2+)as a multifunctional modulator is required for spermiogenesis in Ascaris suum显示文摘The dynamic polar polymers actin fi laments and microtu-bules are usually employed to provide the structural ba-sis for establishing cell polarity in most eukaryotic cells.Radially round and immotile spermatids from nematodes contain almost no actin or tubulin,but still have the abil-ity to break symmetry to extend a pseudopod and initiate the acquisition of motility powered by the dynamics of cytoskeleton composed of major sperm protein(MSP)during spermiogenesis(sperm activation).However,the signal transduction mechanism of nematode sperm activation and motility acquisition remains poorly under-stood.Here we show that Ca^(2+) oscillations induced by the Ca^(2+) release from intracellular Ca^(2+) store through inositol(1,4,5)-trisphosphate receptor are required for Ascaris suum sperm activation.The chelation of cytosolic Ca^(2+) suppresses the generation of a functional pseudopod,and this suppression can be relieved by introducing ex-ogenous Ca^(2+) into sperm cells.Ca^(2+) promotes MSP-based sperm motility by increasing mitochondrial membrane potential and thus the energy supply required for MSP cytoskeleton assembly.On the other hand,Ca^(2+) promotes MSP disassembly by activating Ca^(2+)/calmodulin-depend-ent serine/threonine protein phosphatase calcineurin.In addition,Ca^(2+)/camodulin activity is required for the fusion of sperm-specifi c membranous organelle with the plasma membrane,a regulated exocytosis required for sperm mo-tility.Thus,Ca^(2+)plays multifunctional roles during sperm activation in Ascaris suum.	Yunlong Shang Lianwan Chen Zhiyu Liu Xia Wang Xuan Ma Long Miao	2013	Protein & Cell2013，4，6：	0

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