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| 1 | 乙型肝炎病毒导致的肝硬化伴肝癌患者血清中N糖组学改变显示文摘肝细胞癌(HCC)是最常见的肿瘤和最主要的死因之一,多发生于HBV和HCV感染导致的肝硬化患者,筛查肝硬化人群,早期诊断HCC可降低肿瘤的病死率。甲胎蛋白(AFP)是目前广泛应用的辅助诊断HCC的血清学指标,是对B超、CT等影像学诊断的有效补充。最近的荟萃分析表明,不同研究论文报道的AFP的灵敏度和特异度有很大的不同,这种现象不能完全用AFP的临界值不同解释。血清中的N糖蛋白主要由肝脏和B淋巴细胞合成,N糖成分的改变可反应肝脏或B淋巴细胞功能的改变,糖链的改变常常反应出机体的异常改变。糖组学在诊断领域的应用曾经因为缺少合适的分析技术而受限制,血清中N糖组学分析技术克服了这一屏障。本研究的目的是评价血清中N糖指纹图谱应用于乙型肝炎后肝硬化伴肝癌辅助诊断的意义。 | 刘学恩 Liesbeth Desmyter 高春芳 Wouter Laroy Sylviane Dewaele Valerie Vanhooren 王玲 庄辉 Nico Callewaert Claude Libert Roland Contreras 陈翠英 | 2008 | 中华肝脏病杂志2008，16，1： | 11 |
| 2 | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease:more than just a barrier显示文摘The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial(CPE) cells surrounding fenestrated capillaries.These CPE cells not only form an anatomical barrier,called the blood-cerebrospinal fluid barrier(BCSFB),but also present an active interface between blood and cerebrospinal fluid(CSF).CPE cells perform indispensable functions for the development,maintenance and functioning of the brain.Indeed,the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules,such as nutrients,neurotrophins,and growth factors,as well as by clearing toxic and undesirable molecules from CSF.The choroid plexus also acts as a selective entry gate for leukocytes into the brain.Recent findings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer's disease.In this review,we review some recent findings that highlight the importance of the CPE-CSF system in Alzheimer's disease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy. | Sriram Balusu Marjana Brkic Claude Libert Roosmarijn E.Vandenbroucke | 2016 | Neural Regeneration Research2016，11，4： | 2 |
| 3 | 联合应用维甲酸和干扰素对膀胱癌细胞生长抑制及诱导凋亡作用的实验研究显示文摘目的 探讨联合应用维甲酸和干扰素对人膀胱癌细胞生长抑制和诱导凋亡的作用机理。 方法 应用全反式维甲酸 (ATRA)、9 顺式维甲酸 (9cRA)、联合干扰素α 2a(IFNα 2a)作用于 4组膀胱癌细胞 ,应用TUNEL、FCM、RT PCR及Western等技术观察维甲酸、干扰素单独或联合应用时对不同膀胱癌细胞株的生长抑制、诱导凋亡作用以及核维甲酸类受体、Stat1蛋白等方面的改变。 结果 ATRA和 9cRA对所有膀胱癌细胞的抑制生长和诱导凋亡作用均不明显 ,而IFNα 2a能增强ATRA和9cRA对膀胱癌的这种作用 ,联合应用ATRA和IFNα 2a能诱导膀胱癌细胞RARβ受体和Statl的表达。 结论 IFNα 2a能协同ATRA和 9cRA对膀胱癌细胞生长抑制和凋亡诱导效应 ,上调Stat1基因表达可能是其主要分子学作用机理。 | 钱立新 Monica Libert Changchun Zou Changping Zou | 2004 | 中华泌尿外科杂志2004，25，6： | 2 |
| 4 | Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene显示文摘 | Samson M Libert F Doranz BJ | | 0，，6593： | 1 |
| 5 | Matrix metalloprotein- ases as drug targets in ischemia/repeffusion injury 显示文摘 | Dejonckheere E Vandenbroucke RE Libert C | 2011 | Drug Discov Today2011，16，1718： | 1 |
| 6 | Reduction of wound-induced respiration and ethylene production in carrot root tissues by gamma irradiation 显示文摘 | Chervin C Triantaphylides C Libert M F | 1992 | Postharvest Biology and Technology1992，8，2： | 1 |
| 7 | 查看详情显示文摘 | Liberts G Mitrofanov Y Cebers A | | 0，，： | 1 |
| 8 | Faetors that intluence cancer patients: anxieqy following a medical consultation: impact of a communication skills training programme for physicians显示文摘 | Lienard A Merckaert I Libert Y | 2006 | Ann Oneol2006，17，9： | 1 |
| 9 | Prognostic factors for survival in advanced non-small cell lung cancer: uni-and multivariate analysis including RECPAM in 1 052 patients 显示文摘 | Paemans M Sculler J P Libert P | 1995 | J Clin Oncol1995，13，： | 1 |
| 10 | SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive显示文摘 | Libert S Pointer K Bell EL | 2011 | Cell2011，147，7： | 1 |
| 11 | Retinal Toxicity of Intravitreal Gentamicin显示文摘 | D'Amico DJ Libert J Kenyon KR | 1984 | Invest Ophthalmol Vis Sci1984，25，5： | 1 |
| 12 | Mobilization and utilization of cyanogenic glycosides显示文摘 | Selnard Libert R BeihLB | 1988 | Plant Physiol1988，86，： | 1 |
| 13 | The second ex-tracellular loop of CCR5 is the major determinant of lig-and specificity 显示文摘 | Samson M LaRosa G Libert F | 1997 | J Biol Chem1997，272，24： | 1 |
| 14 | Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1 显示文摘 | van Hauwermeiren F Vandenbroucke RE Libert C | 2011 | Cytokine Growth Factor Rev2011，22，56： | 1 |
| 15 | Matrix metallo- proteinases as drug targets in ischemia/reperfusion injury 显示文摘 | Dejonckheere E Vandenbroucke RE Libert C | 2011 | Drug Discov Today2011，16，1718： | 1 |
| 16 | Prognostic factors for survival in advanced non-small-cell lung cancer:Univariate and multivariate analysis including recursive partitioning and amalgamation algorithms in 1052 patientsl 显示文摘 | Paesmans M Sculier JP Libert P | 1995 | J Clin Oncol1995，13，5： | 1 |
| 17 | Complete nucleotide sequence of a putative G protein coupled receptor: RDC1 显示文摘 | Libert F Parmentier M Lefort A | 1990 | Nucleic Acids Res1990，18，7： | 1 |
| 18 | Key evolution systems in untrusted update environments显示文摘 | Libert B Quisquater J Yung M | 2010 | ACM Yrans on Information and Systems Security2010，13，4： | 1 |
| 19 | prognostic factors for survival in advanced non-small cell lung cancer:univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1052 patients显示文摘 | Paesmans M Sculie JP Libert G | 1995 | J Clin Oncol1995，13，5： | 1 |
| 20 | Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene 显示文摘 | Samson M Libert F Doranz BJ | 1996 | Nature1996，382，6593： | 1 |
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