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| 1 | 实时荧光定量PCR分析雌激素受体相关受体α,β,γ与雌激素受体α,β在卵巢癌中mRNA的表达模式显示文摘目的:明确孤儿受体—雌激素受体相关受体(estrogen receptor-related recep-tor,ERRs)各亚型以及雌激素受体亚型在卵巢癌中mRNA的表达模式。方法:采用Light-Cycler-PCR定量检测40例卵巢癌标本以及15例正常卵巢组织中各种ERRs亚型和ERs亚型mRNA的表达丰度。采用ELISA方法分析各样本血清CA-125水平。结果:卵巢癌组织中ERRαmRNA表达的丰度和阳性表达率显著高于正常卵巢组织(P=0.04和P=0.02),ERRβ在卵巢癌组织和正常卵巢组织中的RNA表达的丰度和阳性表达率差异无统计学意义(P>0.05);ERRγmRNA在正常卵巢以及卵巢癌组织中表达的丰度差异无统计学意义(P>0.05),但卵巢癌组织中ERRγ的阳性表达率显著增高(P=0.045)。ERRs家族和ERs家族在卵巢癌中有很高的共同表达率,ERα/ERRα的比率在卵巢癌组织中明显下降(P=0.0412)。结论:ERRs与ERs在卵巢癌中有共同表达,两个家族间的相互作用可能是卵巢癌复杂的肿瘤内分泌生物学行为的分子基础。 | 孙蓬明 魏丽惠 高敏 王建六 赵超 W Lichtenegger J Sehouli | 2006 | 现代妇产科进展2006，15，4： | 6 |
| 2 | Simulation of spray coating in a spouted bed using recurrence CFD显示文摘Although numerical models such as the computational fluid dynamics–discrete element method (CFD–DEM) have enabled the accurate simulation of laboratory-scale apparatuses, the application of these methods to large-scale apparatuses with many particles and time scales ranging from minutes to hours remains a challenge. The recently developed recurrence CFD (rCFD) method seeks to overcome these issues in pseudo-periodic processes by extrapolating globally recurring patterns in a physically meaningful way and describing the transport and interaction of passive scalars using Lagrangian tracers. Spouted beds represent an interesting target because of the associated variety of flow regimes. They can be effectively described by CFD–DEM on the time scale of tens of seconds, whereas industrially relevant processes typically take hours. In this contribution, we established the validity of applying the Lagrangian rCFD method to spouted beds by demonstrating the accurate reproduction of the particle residence time distribution in a fictitious spray zone. The deposition of spray droplets onto tracer particles was simulated for 1 h, and the particle surface coverage distribution was estimated using a statistical approach for both an unstabilized prismatic spouted bed and one stabilized by draft plates. | Paul Kieckhefena Thomas Lichtenegger Swantje Pietsch Stefan Pirker Stefan Heinrich | 2019 | Particuology2019，17，1： | 2 |
| 3 | Surgical anatomy of the larynx 显示文摘 | FRIEDRICH G LICHTENEGGER R | 1997 | J Voice1997，11，3： | 1 |
| 4 | Urologieal complications after radical abdominal hysterectomy for cervical cancer显示文摘 | Ralph G Tamussino K Lichtenegger W | 1988 | Baillieres Clin Obstet Gynaecol1988，2，4： | 1 |
| 5 | Neural networkg for oil sspill detection using ERS-SAR data 显示文摘 | Frate F D Petroechi A Lichtenegger J | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，5，： | 1 |
| 6 | Einfluβ unterschiedlicher Schmelz-parameter auf die Ausbildung der MC-Karbide im Schnellarbeitsstahl S 6-5-2显示文摘 | G Pockl G Hackl G Lichtenegger and F Jeglitsch | 1995 | Sonderb(a)nde der Praktischen Metallographie1995，27，： | 1 |
| 7 | Neural networks for oil spill detection using ERS- SAR data显示文摘 | Fabio Del Frate Andrea Petrocchi Juerg Lichtenegger | 2000 | IEEE Transac-tions on Geoscience and Remote Sensing2000，38，5： | 1 |
| 8 | Electrochemical synthesis of nanostructured ZnO films utilizing self-assembly of surfactant molecules at solid-liquid interfaces显示文摘 | CHOI K S LICHTENEGGER H C STUCKY G D | 2002 | J Am Chem Soe2002，124，12： | 1 |
| 9 | Urological complications following radical abdominal hysterectomy for cervical cancer显示文摘 | Ralph G Tamussino K Lichtenegger W | 1988 | Arch Gynecol Obstet1988，243，： | 1 |
| 10 | Neoadjuvant letrozole in postmenopausal oestrogen and/or proges- terone receptor positive breast cancer: a phase II b/]]I trial to in- vestigate optimal duration of preoperative endocrine therapy 显示文摘 | Krainick-Strobel UE Lichtenegger W Wallwiener D | 2008 | BMC Cancer2008，8，： | 1 |
| 11 | Immunotherapy for acute myeloid leukemia 显示文摘 | Lichtenegger FS Krupka C Kihnke T | 2015 | Semin Hematol2015，52，3： | 1 |
| 12 | Neoadjuvant letrozole in postmenopausal estrogen and/or pro gesterone receptor positive breast cancer: a phase Ⅱ b/Ⅲ trial to investigate optimal duration of preoperative endocrine therapy 显示文摘 | Krainiek-Strobel U E Lichtenegger W Wallwiener D | 2008 | BMC Cancer2008，26，8： | 1 |
| 13 | The importance of parametrial lymph nodes in the treatment of cervicad cancer显示文摘 | Grardi F Lichtenegger W Tamassino K | | 0，，02： | 1 |
| 14 | Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission 显示文摘 | Beck B Dtirfel D Lichtenegger FS | 2011 | J Transl Med2011，9，： | 1 |
| 15 | Cyclin-dependant kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer显示文摘 | Annette Schmider-Ross Olaf Pirsig Elisabeth Gottschalk Carsten Denkert Werner Lichtenegger Angela Reles | 2006 | Journal of Cancer Research and Clinical Oncology2006，，3： | 1 |
| 16 | Neoadjuvant letrozole in post - menopausal estrogen and/or progesterone receptor positive breast cancer: A phase Ⅱ b/Ⅲ trial to investigate optimal duration of preoperative endocrine therapy 显示文摘 | Krainick - Strobel UE Lichtenegger W Wallwiener D | 2008 | BMC Cancer2008，8，： | 1 |
| 17 | The importance of parametrial lymph nodes in the treatment of cervical cancer显示文摘 | Girardi F Lichtenegger W Tamussino K | 1989 | Gynecol Oncol1989，34，： | 1 |
| 18 | Neoad- juvant letrozole in postmenopausal estrogen and/or progesterone re- ceptor positive breast cancer: a phase I1 b/Ill trial to investigate optimal duration of preoperative endocrine therapy显示文摘 | Krainick-Strobel UE Lichtenegger W Wallwiener D | 2008 | BMC Canc- er2008，8，： | 1 |
| 19 | Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer:A phase Ⅱb/Ⅲtrial to investigate optimal dtLration of preoperative endocrine therapy显示文摘 | Lichtenegger W | 2008 | BMC Concer2008，26，8： | 1 |
| 20 | Urological complications follow- ing radical abdominal hysterectomy for cervical cancer显示文摘 | Ralph G Tamussino K Lichtenegger W | 1988 | Arch Gynecol Obstet1988，243，： | 1 |
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