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| 1 | Human amnion epithelial cells can be induced to differentiate into functional insulin-producing cells显示文摘胰腺的小岛移植证明了长期的胰岛素独立可以在受不了糖尿病 mellitus 类型 1 的病人被完成。然而,小岛织物的有限可获得性意味着对葡萄糖应答的生产胰岛素的房间的新来源被要求。这里,我们显示出那人的羊膜上皮的房间(HAEC ) 能被导致在 vitro 区分进功能的生产胰岛素的房间。在区别的正式就职以后, HAEC 表示了多重胰腺的 β-cell 基因,包括胰岛素,胰十二指肠 homeobox-1,配对的盒子基因 6, NK2 抄写因素相关的地点 2,小岛 1, glucokinase,和葡萄糖 transporter-2,和以响应另外的细胞外的刺激的一种调整葡萄糖的方式的释放 C 肽。进导致 streptozotocin 的糖尿病的 C57 老鼠的导致的 HAEC 的移植颠倒了多糖症,恢复了身体重量,并且维持了为 30 d 的 euglycemia。这些调查结果显示 HAEC 可以是为在类型 1 糖尿病的房间代替治疗的新来源。 | Yanan Hou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 25 |
| 2 | Groundwater Systems and Resources in the Ordos Basin,China显示文摘Ordos 盆是在西北的中国的大规模沉积的盆。到顶的从底部的 hydrostratigraphic 单位是 pre 寒武纪的变形岩石,更低的古生代的碳酸盐岩石,上面对中生代碎屑状的岩石和新生代存款古生代。全部的厚度直到 6000 m。三个地下水系统在 Ordos 盆是在场的,基于地质的设置,即石灰岩地区常见的地形地下水系统,白垩纪碎屑状的地下水系统和第四级的地下水系统。这份报纸系统地描述每个系统的地下水流动模式和对地下水资源的全面评价。 | HOU Guangcai LIANG Yongping SU Xiaosi ZHAO Zhenghong TAO Zhengping YIN Lihe YANG Yuncheng WANG Xiaoyong | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 5 |
| 3 | Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas显示文摘 | Liyu Li Jianjun Hou Xinjie Liu Yujia Guo Yun Wu Lihe Zhang Zhenjun Yang | 2014 | Biomaterials2014，，： | 1 |
| 4 | Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng C.A.Mey.显示文摘Panax ginseng C.A.Mey.is an important plant species used in traditional Chinese medicine,whose primary active ingredient is a ginsenoside.Ginsenoside biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural genes.Nonetheless,the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary metabolites.Squalene epoxidase(SQE)is a key enzyme in the mevalonic acid pathway,which affects the biosynthesis of secondary metabolites such as terpenoid.Using ginseng transcriptome,expression,and ginsenoside content databases,this study employed bioinformatic methods to systematically analyze the genes encoding SQE in ginseng.We first selected six PgSQE candidates that were closely involved in ginsenoside biosynthesis and then identified PgSQE08-01 to be highly associated with ginsenoside biosynthesis.Next,we constructed the overexpression vector pCAMBIA3301-PgSQE08-01 and the RNAi vector pART27-PgSQE08-01 and transformed ginseng adventitious roots using Agrobacterium rhizogenes,to obtain positive hairy-root clones.Thereafter,quantitative reverse transcriptionpolymerase chain reaction and high-performance liquid chromatography were used to determine the expression of relevant genes and ginsenoside content,respectively.Then,we focused on the function of PgSQE08-01 gene,which was noted to be involved in ginsenoside biosynthesis.Thus,these findings not only provided a molecular basis for the identification of important functional genes in ginseng but also enriched genetic resources for the biosynthesis of ginsenosides using synthetic biology. | Lei Zhu Lihe Hou Yu Zhang Yang Jiang Yi Wang Meiping Zhang Mingzhu Zhao Kangyu Wang | 2024 | Phyton-International Journal of Experimental Botany2024，93，2： | 0 |
| 5 | Acetylcholinesterase is associated with apoptosis in β cells and contributes to insulin-dependent diabetes mellitus pathogenesis显示文摘Acetylcholinesterase (疼痛) 表示在 apoptosis 期间是枢轴的。确实,疼痛禁止者部分保护房间免受 apoptosis 的伤害。胰岛素依赖者糖尿病 mellitus (IDDM ) 被胰腺的房间 apoptosis 部分地描绘。这里,我们在 IDDM 的发展调查了疼痛的角色并且分析了疼痛禁止者的保护的效果。多重低剂量的 streptozotocin (MLD-STZ ) 管理在一个老鼠模型导致了 IDDM。西方的污点分析,细胞化学的染色,并且染色的 immunofluorescence 被用来在 MIN6 房间,主要房间,和 apoptotic 检测疼痛表示 MLD-STZ-treated 老鼠的胰腺的房间。疼痛禁止者予 MLD-STZ 老鼠 intraperitoneally 被以 30 天。血葡萄糖,血浆胰岛素,和肌酸层次被测量,并且葡萄糖忍耐测试被执行。MIN6 房间上的疼痛禁止者的效果也被评估。当与 STZ 对待时,疼痛表示在 vivo 在 vitro 和胰腺的小岛在 apoptotic MIN6 房间和主要房间被导致。正式就职和在胰腺的小岛的疼痛的进步累积在 IDDM 开发期间与 apoptotic 房间被联系。疼痛禁止者的管理有效地减少了在 MLD-STZ 老鼠的糖尿病的多糖症和发生,和恢复血浆胰岛素层次和血浆肌酸清理。疼痛禁止者部分保护了 MIN6 房间免受 STZ 治疗引起的损坏的伤害。在胰腺的小岛和 IDDM 的发作和发展上的疼痛禁止者的保护的效果的疼痛的正式就职和累积显示在疼痛和 IDDM 之间的一种靠近的关系。 | Bao Zhang Lei Yang Luyang Yu Bo Lin Yanan Hou Jun Wu Qin Huang Yifan Han Lihe Guo Qi Ouyang Bo Zhang Lu Lu Xuejun Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，3： | 0 |
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