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您的检索式：作者名="Lihui Yuwen"
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| 1 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 2 | Reduced gra- phene oxide/PAMAM-silver nanoparticles nanocomposite modified electrode for direct electrochemistry of glucose oxidase and glucose sensing 显示文摘 | Luo Zhimin Yuwen Lihui Hart Yujie | 2012 | Biosensors and Bioelec- tronics2012，36，： | 1 |
| 3 | Inclusion of tetracycline hydrochloride within supramolecular gels and itscontrolled release to bovine serum albumin显示文摘 | CHEN Liqin WU Junchen YUWEN Lihui | 2009 | Langmuir2009，25，15： | 1 |
| 4 | Crea- ting SERS hot spots on MoS2 nanosheets with in situ grown gold nanoparticles 显示文摘 | SU Shao ZHANG Chi YUWEN Lihui | 2014 | ACS Applied Materials Interfaces2014，6，18： | 1 |
| 5 | Reduced graphene oxide/ PAMAM - silver nanoparticles nanocomposite modified electrode for direct electrochemistry of glucose oxidase and glucose sensing 显示文摘 | Zhimin Luo Lihui Yuwen Ytijie Han | 2012 | Biosensors and Bioelectronics2012，36，： | 1 |
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