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您的检索式：作者名="Lilan Zeng"
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| 1 | Effects of combined chemical design(Cu addition) and topographical modification(SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities显示文摘Cu has been proved to possess various beneficial biological activities, while sandblasting and acid etching(SLA) is widely used to modify the commercial dental implant in order to improve osseointegration. Based on the above, a novel antimicrobial dental implant material, Ti-Cu alloy, was treated with SLA, to combine chemical design(Cu addition) and topographical modification(SLA). In this work, the effects of SLA treated Ti-Cu alloys(Ti-Cu/SLA) on osteogenesis, angiogenesis and antibacterial properties were evaluated from both in vitro and in vivo tests, and Ti/SLA and Ti-Cu(without SLA) were served as control groups. Benefiting by the combined effects of chemical design(Cu addition) and micro-submicron hybrid structures(SLA),Ti-Cu/SLA had significantly improved inhibitory effects on oral anaerobic bacteria(P. gingivalis and S.mutans) and could induce upregulation of osteogenic-related and angiogenic-related genes expression in vitro. More importantly, in vivo studies also demonstrated that Ti-Cu/SLA implants had wonderful biological performance. In the osseointegration model, Ti-Cu/SLA implant promoted osseointegration via increasing peri-implant bone formation and presenting good bone-binding, compared to Ti/SLA and Ti-Cu implants. Additionally, in the peri-implantitis model, Ti-Cu/SLA effectively resisted the bone resorption resulted from bacterial infection and meanwhile promoted osseointegration. All these results suggest that the novel multiple functional Ti-Cu/SLA implant with rapid osseointegration and bone resorption inhibition abilities has the potential application in the future dental implantation. | Rui Liu Yulong Tang Hui Liu Lilan Zeng Zheng Ma Jun Li Ying Zhao Ling Ren Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，12： | 6 |
| 2 | In vitro and in vivo antibacterial performance of Zr&O PIII magnesium alloys with high concentration of oxygen vacancies显示文摘The effects of dual Zr and O plasma immersion ion implantation(Zr&O PIII)on antibacterial properties of ZK60 Mg alloys are systematically investigated.The results show that a hydrophobic,smooth,and ZrO_(2)-containing graded film is formed.Electrochemical assessment shows that the corrosion rate of the plasma-treated Mg alloy decreases and the decreased degradation rate is attributed to the protection rendered by the surface oxide.In vitro and in vivo antibacterial tests reveal Zr&O PIII ZK60 presents higher antibacterial rate compared to Zr PIII ZK60 and untreated control.The hydrophobic and smooth surface suppresses bacterial adhesion.High concentration of oxygen vacancies in the surface films are determined by X-ray photoelectron spectroscopy(XPS),UV-vis diffuse reflectance spectra(UV-vis DRS)and electron paramagnetic resonance(EPR)and involved in the production of reactive oxygen species(ROS).The higher level of ROS expression inhibits biofilm formation by down-regulating the expression of icaADBC genes but up-regulating the expression of icaR gene.In addition,Zr&O PIII improves cell viability and initial cell adhesion confirming good cytocompatibility.Dual Zr&O PIII is a simple and practical means to expedite clinical acceptance of biodegradable magnesium alloys. | Tao Liang Lilan Zeng Yunzhu Shi Haobo Pan Paul K.Chu Kelvin W.K.Yeung Ying Zhao | 2021 | Bioactive Materials2021，6，10： | 0 |
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