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| 1 | A zenith tropospheric delay correction model based on the regional CORS network显示文摘Tropospheric delay is a primary error source in earth observations and a variety of radio navigation technologies. In this paper, the relationship between zenith tropospheric delays and the elevation and longitude of stations is analyzed using the zenith tropospheric delay final products of International GNSS Service (IGS) stations from 2011. Two new models are proposed for estimating zenith tropospheric delays from regional CORS data without meteorological data. The proposed models are compared with the direct interpolation method and the remove-restore method using data from Guangxi CORS. The results show that the new models significantly improve the calculated precision. Finally, the root mean square (RMS) errors of the new models were used to estimate the surface precipitable water vapor (PWV) value at CORS station, which was determined to be less than 2 mm. | Huang Liangke Liu Lilong Yao Chaolong | 2012 | Geodesy and Geodynamics2012，3，4： | 11 |
| 2 | Study of the tolerance of Hippochaete ramosissimum to Cu stress显示文摘We investigated the tolerance of Hippochaete ramosissimum and the changes in physiological metabolism following exposure to copper using pot experiments and analyzing plant physiology and biochemistry. The results showed that Cu tolerance in Hippochaete ramosissimum varied significantly between different populations; the tolerance of plants living in Cu polluted areas for extended periods of time exceeded that of plants living in unpolluted areas.SOD and POD activities in highly Cu tolerant plants increased noticeably following exposure to Cu. This indicates that maintaining and increasing the two kinds of protective enzyme activities are the primary foundations of plant tolerance. However, no change in CAT activity was demonstrated following Cu exposure. In summary, there existed considerable differences in physiological metabolism between different populations of Hippochaete ramosissimum following exposure to Cu. | LIU Dengyi, LI Ying, CHU Ling, WANG Guanglin & WANG Lilong Biodiversity Research Center, Anhui Normal University, Wuhu 241000, China The Provincial Key Laboratory of Conservation and Exploitation of Biological Resources in Anhui, Wuhu 241000, China | 2005 | Science China(Life Sciences)2005，48，z1： | 7 |
| 3 | Spatiotemporal characteristics of GNSS-derived precipitable water vapor during heavy rainfall events in Guilin,China显示文摘Precipitable Water Vapor(PWV),as an important indicator of atmospheric water vapor,can be derived from Global Navigation Satellite System(GNSS)observations with the advantages of high precision and all-weather capacity.GNSS-derived PWV with a high spatiotemporal resolution has become an important source of observations in mete-orology,particularly for severe weather conditions,for water vapor is not well sampled in the current meteorological observing systems.In this study,an empirical atmospheric weighted mean temperature(Tm)model for Guilin is estab-lished using the radiosonde data from 2012 to 2017.Then,the observations at 11 GNSS stations in Guilin are used to investigate the spatiotemporal features of GNSS-derived PWV under the heavy rainfalls from June to July 2017.The results show that the new Tm model in Guilin has better performance with the mean bias and Root Mean Square(RMS)of−0.51 and 2.12 K,respectively,compared with other widely used models.Moreover,the GNSS PWV estimates are validated with the data at Guilin radiosonde station.Good agreements are found between GNSS-derived PWV and radiosonde-derived PWV with the mean bias and RMS of−0.9 and 3.53 mm,respectively.Finally,an investigation on the spatiotemporal characteristics of GNSS PWV during heavy rainfalls in Guilin is performed.It is shown that variations of PWV retrieved from GNSS have a direct relationship with the in situ rainfall measurements,and the PWV increases sharply before the arrival of a heavy rainfall and decreases to a stable state after the cease of the rainfall.It also reveals the moisture variation in several regions of Guilin during a heavy rainfall,which is significant for the moni-toring of rainfalls and weather forecast. | Liangke Huang Zhixiang Mo Shaofeng Xie Lilong Liu Chuanli Kang Shitai Wang | 2021 | Satellite Navigation2021，2，1： | 6 |
| 4 | Empirical T_m modeling in the region of Guangxi显示文摘This paper presents three strategies for modeling the regional empirical T_m (the weighted mean temperature of the atmosphere) to obtain more accurate determinations in a regional empirical model that is better adapted to the geographical and climatic characteristics of the applied area. The proposed models utilize data from four radiosonde stations in Guangxi, at Nanning, Guilin, Wuzhou and Baise, over an 11 month period (from Jan. to Nov. of 2011). The experimental results demonstrated the following: (1) there is no significant difference between monthly and annual regression results at each site; (2) it is more reasonable and feasible to use the proposed regional Hybrid model for the area far away from the radiosonde site; (3) from the analysis of the possible temperature conditions, the precision of the proposed regional Hybrid model is higher than that of the well-known Bevis formula and of some other existing models and can reach an accuracy within 1 mm for the GPS-derived PWV estimates for the applied region. | Liu Lilong Yao Chaolong Wen Hongyan | 2012 | Geodesy and Geodynamics2012，3，4： | 5 |
| 5 | High flux photocatalytic self-cleaning nanosheet C_(3)N_(4) membrane supported by cellulose nanofibers for dye wastewater purification显示文摘Hazardous dye substances discharged from the textile and dyestuff industries not only threaten local the surrounding ecosystems but are also hard to degraded.We report the preparation of process for a photocatalytic membrane device that can degrade dye pollution under visible light.This filtration membrane,with a well-organized multilayer structure,simultaneously achieves continuous and flow-through separation of degradation products.Cellulose nanofibers(CNFs)were used as a template for nanosheet C_(3)N_(4)(NS C_(3)N_(4))preparation;the performance for the photocatalytic degradation of dyes improved as the morphology changed from bulking to nanosheet.NS C3N4 was then attached to the surface of a prepared CNF membrane via vacuum filtration.This device exhibited high efficiency(the degradation rates of both Rhodamine B and Methylene blue both reached 96%),high flux(above 160 L·h^(-1)·m^(-2)·bar^(-1))and excellent stability(maintaining steady flux and high separation were maintained after 4 h).This easy-preparation,easy-scale-up,and low-cost process provides a new method of fabricating photocatalytic membrane devices for dye wastewater treatment. | Lilong Zhang Ge Meng Guifang Fan Keli Chen Yulong Wu Jian Liu | 2021 | Nano Research2021，14，8： | 3 |
| 6 | Triggering in-plane defect cluster on MoS_(2) for accelerated dinitrogen electroreduction to ammonia显示文摘Electrochemical nitrogen reduction reaction (eNRR) is an alternative promising manner for sustainable N2 fixation with low-emission. The major challenge for developing an efficient electrocatalyst is the cleaving of the stable Ntriple bondN triple bonds. Herein, we design a new MoS_(2) with in-plane defect cluster through a bottom-up approach for the first time, where the defect cluster is composed of three adjacent S vacancies. The well-defined in-plane defect clusters could contribute to the strong chemical adsorption and activation towards inert nitrogen, achieving an excellent eNRR performance with an ammonia yield rate of 43.4 ± 3 μg h^(−1) mgcat.^(−1) and a Faradaic efficiency of 16.8 ± 2% at −0.3 V (vs. RHE). The performance is much higher than that of MoS_(2) with the edge defect. Isotopic labeling confirms that N atoms of produced NH4+ originate from N2. Furthermore, the in-plane defect clusters realized the alternate hydrogenation of nitrogen in a side-on way to synthesize ammonia. This work provides a prospecting strategy for fine-tuning in-plane defects in a catalyst, and also promotes the progress of eNRR. | Wanru Liao Ke Xie Lijuan Liu Xiuyun Wang Yu Luo Shijing Liang Fujian Liu Lilong Jiang | 2021 | Journal of Energy Chemistry2021，30，11： | 3 |
| 7 | Differential efficiency of a begomovirus to cross the midgut of different species of whiteflies results in variation of virus transmission by the vectors显示文摘Begomoviruses are important crop viral disease agents, and they are transmitted by whiteflies of the Bemisia tabaci complex.Although the transmission of begomoviruses by whiteflies has been studied for many years, the mechanisms governing differential transmission of begomoviruses by different species of the Bemisia tabaci complex remain largely unknown. Here we firstly compared the transmission efficiency of tobacco curly shoot virus(TbCSV) by four species of the B. tabaci complex and found that Asia II 1 transmitted this virus with the highest efficiency, whereas MEAM1 transmitted it with the lowest. Next, by performing quantitative analysis of virus and immune-fluorescence detection, we found that the efficiency of TbCSV to cross the midgut wall was higher in Asia II 1 than in MEAM1. Finally, we set the quantities of virions in the haemolymph to the same level in Asia II 1 and MEAM1 via injection and then compared their capacity in TbCSV transmission, and found that the difference in TbCSV transmission between them became smaller. Taken together, our findings suggest that the efficiency of a begomovirus to cross the midgut wall of a whitefly to reach the vector's haemolymph plays a significant role in determining transmission of the virus. | Lilong Pan Qunfang Chen Tao Guo Xinru Wang Ping Li Xiaowei Wang Shusheng Liu | 2018 | Science China(Life Sciences)2018，61，10： | 2 |
| 8 | An individual urinary proteome analysis in normal human beings to define the minimal sample number to represent the normal urinary proteome 显示文摘 | Liu Xuejiao Shao Chen Wei Lilong | 2012 | ProteomeSei2012，10，1： | 1 |
| 9 | Efficient catalytic removal of COS and H_(2)S over graphitized 2D micro-meso-macroporous carbons endowed with ample nitrogen sites synthesized via mechanochemical carbonization显示文摘Developing a suitable catalyst for the elimination of highly toxic carbonyl sulfide(COS)and hydrogen sulfide(H_(2)S) is of great significance in terms of industrial safety and environmental protection.We demonstrate here the facile synthesis of graphitized 2D micro-meso-macroporous carbons by one-step carbonization of a mixture of urea and glucose at 700–900℃.The as-synthesized graphitized catalysts,designated as 2DNHPC-x(x=urea/glucose mass ratio),are endowed with an ultra-high concentration(12.9–20.2 wt%)of stable and versatile nitrogen sites(e.g.pyrrole and pyridine)which are anchored on the surface via stable covalent bonding.As a result,the 2D-NHPC-x are active in catalytic hydrolysis of COS on pyrrolic N to H_(2)S,and the H_(2)S can be subsequently captured on pyridinic N and converted to elemental sulfur at ambient conditions over the same materials.Among the prepared catalysts,2D-NHPC-x can catalytically hydrolysize 91%of COS to H_(2)S at 30℃,whereas the conversion ratio over the common catalysts g-C_(3)N_(4)and Fe_(2)O_(3)are below 6.0%.Furthermore,these catalysts also exhibit H_(2)S conversion and sulfur selectivity of nearly 100%at 180℃with long-time durability,which is higher than those of the most reported carbonbased catalysts.In contrast,the H_(2)S capacities of activated carbon,ordered mesoporous carbons(OMC)and N-doped OMC are 3.9,1.5 and2.39 mmol g^(-1),respectively.Both the experimental and theoretical results are disclosed that 2D-NHPC-x are superior to the nitrogen-doped porous materials ever applied in simultaneous catalytic elimination of both COS and H_(2)S. | Xun Kan Guanqing Zhang Yingying Luo Fujian Liu Yong Zheng Yihong Xiao Yanning Cao Chak-tong Au Shijing Liang Lilong Jiang | 2022 | Green Energy & Environment2022，7，5： | 1 |
| 10 | Evaluation of surface temperature and pressure derived from MERRA-2 and ERA5 reanalysis datasets and their applications in hourly GNSS precipitable water vapor retrieval over China显示文摘Temperature and pressure play key roles in Global Navigation Satellite System(GNSS) precipitable water vapor(PWV) retrieval. The National Aeronautics and Space Administration(NASA) and European Center for Medium-Range Weather Forecasts(ECMWF) have released their latest reanalysis product: the modern-era retrospective analysis for research and applications, version 2(MERRA-2) and the fifthgeneration ECMWF reanalysis(ERA5), respectively. Based on the reanalysis data, we evaluate and analyze the accuracy of the surface temperature and pressure products in China using the the measured temperature and pressure data from 609 ground meteorological stations in 2017 as reference values.Then the accuracy of the two datasets and their performances in estimating GNSS PWV are analyzed. The PWV derived from the pressure and temperature products of ERA5 and MERRA-2 has high accuracy. The annual average biases of pressure and temperature for ERA5 are-0.07 hPa and 0.45 K, with the root mean square error(RMSE) of 0.95 hPa and 2.04 K, respectively. The annual average biases of pressure and temperature for MERRA-2 are-0.01 hPa and 0.38 K, with the RMSE of 1.08 h Pa and 2.66 K, respectively.The accuracy of ERA5 is slightly higher than that of MERRA-2. The two reanalysis data show negative biases in most regions of China, with the highest to lowest accuracy in the following order: the south,north, northwest, and Tibet Plateau. Comparing the GNSS PWV calculated using MERRA-2(GNSS MERRA-2 PWV) and ERA5(GNSS ERA5 PWV) with the radiosonde-derived PWV from 48 co-located GNSS stations and the measured PWV of the co-location radiosonde stations, it is found that the accuracy of GNSS ERA5 PWV is better than that of GNSS MERRA-2 PWV. These results show the different applicability of surface temperature and pressure products from MERRA-2 and ERA5 data, indicating that both have important applications in meteorological research and GNSS water vapor monitoring in China. | Liangke Huang Xiaoyang Fang Tengxu Zhang Haoyu Wang Lei Cui Lilong Liu | 2023 | Geodesy and Geodynamics2023，14，2： | 1 |
| 11 | Low temperature synthesis of YAG:Ce phosphors by LiF assisted sol–gel combustion method显示文摘 | Huan Jiao Qiang Ma Lilong He Zhen Liu Qiaoli Wu | 2009 | Powder Technology2009，，2： | 1 |
| 12 | Effect of pore-size distribution on Ru/ZSM-5 catalyst for enhanced N2 activation to ammonia via dissociative mechanism显示文摘In the present study,a series of Ru/ZSM-5 catalysts with different pore-size distributions were prepared and investigated for NH3 synthesis.Our studies indicate that Ru/ZSM-5-Mic with micropore structure exhibits superior NH3 synthesis rate,which is much higher than those of Ru/ZSM-5-Mac(with macroporous structure)and Ru/ZSM-5-Mes(with mesoporous structure)catalysts.A series of TPD experiments demonstrate that pore-size distributions play an important role in N2 adsorption and activation over Ru/ZSM-5.Moreover,the addition of La significantly promotes the NH3 synthesis performance over Ru/ZSM-5-Mic.Additionally,in situ DRIFTS studies indicate that the main intermediate species over Ru/ZSM-5-Mic are-NH2,and most of the surface hydrogen species desorb following the H2O-formation pathway. | Jihui Cai Congying Wang Yi Liu Jun Ni Bingyu Lin Xiuyun Wang Jianxin Lin Lilong Jiang | 2020 | Journal of Rare Earths2020，38，8： | 1 |
| 13 | Refining the ERA5-based global model for vertical adjustment of zenith tropospheric delay显示文摘Tropospheric delay is an important factor affecting high precision Global Navigation Satellite System(GNSS)positioning and also the basic data for GNSS atmospheric research.However,the existing tropospheric delay models have some problems,such as only a single function used for the entire atmosphere.In this paper,an ERA5-based(the fifth generation of European Centre for Medium-Range Weather Forecasts Reanalysis)global model for vertical adjustment of Zenith Tropospheric Delay(ZTD)using a piecewise function is developed.The ZTD data at 611 radiosonde stations and the MERRA-2(second Modern-Era Retrospective analysis for Research and Applications)atmospheric reanalysis data were used to validate the model reliability.The Global Zenith Tropospheric Delay Piecewise(GZTD-P)model has excellent performance compared with the Global Pressure and Temperature(GPT3)model.Validated at radiosonde stations,the performance of the GZTD-P model was improved by 0.96 cm(23%)relative to the GPT3 model.Validated with MERRA-2 data,the quality of the GZTD-P model is improved by 1.8 cm(50%)compared to the GPT3 model,showing better accuracy and stability.The ZTD vertical adjustment model with different resolutions was established to enrich the model's applicability and speed up the process of tropospheric delay calculation.By providing model parameters with different resolutions,users can choose the appropriate model according to their applications. | Ge Zhu Liangke Huang Yunzhen Yang Junyu Li Lv Zhou Lilong Liu | 2022 | Satellite Navigation2022，3，3： | 1 |
| 14 | Effect of barium and potassium promoter on Co/CeO_2 catalysts in ammonia synthesis显示文摘The Co/CeO_2 catalysts promoted with Ba or K were prepared to study the effect of promoter on the catalytic performance of ammonia synthesis. The results show that the presence of Ba or K promoter changes the properties of CeO_2-supported Co catalysts including the surface area, the crystallite size and the morphology of CeO_2, the reduction degree of cobalt species and the adsorption performance of hydrogen and nitrogen. As a consequence, the samples promoted with an appropriate amount of Ba show higher ammonia synthesis rates, while the catalysts with high Ba loading or K promoter all exhibit low catalytic activities. | Bingyu Lin Yi Liu Lan Heng Jun Ni Jianxin Lin Lilong Jiang | 2018 | Journal of Rare Earths2018，36，7： | 1 |
| 15 | Analysis on accuracy of Engineering Star RTK in cadastral survey based on SOUTH-CORS显示文摘Currently,with the fast development of GPS technique,GPS RTK is rapidly being applied to the cadastral survey. GPS RTK technique not only improves efficiency and accelerates the rate of mapping,but also increases economic efficiency. The authors introduced a method for GPS RTK rapid positioning,which uses continuous operational reference system (CORS) as a base station to change the method of previous map drawing by obtaining real-time three-dimensional coordinates of boundary points and statistically analyzing with the three-dimensional coordinates obtained by Total Station to get the accuracy of GPS RTK real-time coordinates. The application of GPS RTK in practical measurement was discussed when the data link had been lost especially. The results show that the three-dimensional coordinates measured by total station can be replaced by real-time three-dimensional coordinates measured by Engineering Star RTK in the CORS. | SONG Yuanming LIU Lilong HU Jiaxing LIU Jingye | 2010 | Global Geology2010，13，3： | 0 |
| 16 | Oxygen vacancy defects engineering on Cu-doped Co_(3)O_(4) for promoting effective COS hydrolysis显示文摘The activation of H_(2)O is a key step of the COS hydrolysis,which may be tuned by oxygen vacancy defects in the catalysts.Herein,we have introduced Cu into Co_(3)O_(4) to regulate the oxygen vacancy defect content of the catalysts.In situ DRIFTS and XPS spectra reveal that COS and H_(2)O are adsorbed and activated by oxygen vacancy.The 10 at%Cu doped Co_(3)O_(4) sample(10Cu-Co_(3)O_(4))exhibits the optimal activity,100%of COS conversion at 70℃.The improved oxygen vacancies of CueCo_(3)O_(4) accelerate the activation of H_(2)O to form active -OH.COS binds with hydroxyl to form the intermediate HSCO^(-)_(2),and then the activated-OH on the oxygen vacancy reacts with HSCO^(-)_(2) to form HCO^(-)_(3).Meanwhile,the catalyst exhibits high catalytic stability because copper species(Cu+/Cu^(2+))redox cycle mitigate the sulfation of Co_(3)O_(4)(Co^(2+)/Co^(3+)).Our work offers a promising approach for the rational design of cobalt-related catalysts in the highly efficient hydrolysis COS process. | Guanyu Mu Yan Zeng Yong Zheng Yanning Cao Fujian Liu Shijing Liang Yingying Zhan Lilong Jiang | 2023 | Green Energy & Environment2023，8，3： | 0 |
| 17 | Fault-distribution-dependent reliable control for time-varying delay system显示文摘This paper considers the problem of reliable control for continuous-time systems with interval time-varying delay. By introducing a random matrix, a new practical actuator fault model is established. Using the Lyapunov-Krasovskii approach, a sufficient condition for the existence of reliable controller is expressed by a linear matrix inequality(LMI). An illustrative example is exploited to show the effectiveness of the proposed design procedures. | Zhou GU Jinliang LIU Lilong DU Engang TIAN | 2011 | 控制理论与应用(英文版)2011，9，4： | 0 |
| 18 | Efficient Preparation of Nanoparticle-Reinforced Nickel-based Composite Coating with Highly Preferred(220)Orientation显示文摘Nanoparticle-reinforced metal matrix composite coatings have significant potential in mechanical part surface strengthening owing their excellent mechanical properties.This paper reports a phenomenon in which the grain orientation gradually evolves to(220)as the deposition current density increases when preparing nanoparticle-reinforced nickel-based composite coatings through jet electrodeposition(JED).During the preparation of the Ni-SiC composite coatings,the deposition current density increased from 180 A/dm2 to 220 A/dm2,and TC(220)gradually increase from 41.4%to 97.7%.With an increase of TC(220),the self-corrosion potential increases from−0.575 to−0.477 V,the corrosion current density decreases from 9.52μA/cm^2 to 2.76μA/cm^2,the diameter of the corrosion pits that after 10 days of immersion in a 3.5 wt%NaCl solution decreases from 278–944 nm to 153–260 nm,and the adhesion of the coating increases from 24.9 N to 61.6 N.Compared a conventional electrodeposition(CED),the Ni-SiC composite coating using JED has the advantages of a smooth surface morphology,high corrosion resistance,and strong adhesion,which are more obvious with an increase in TC(220). | Renjie Ji Hui Jin Yonghong Liu Tiancong Dong Fan Zhang Lilong Zhao Xinlei Wu Qiang Sun Peng Liu Hang Dong Chi Ma Dege Li Baoping Cai | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 0 |
| 19 | An ERA5 tropospheric parameters-augmented approach for improving GNSS precise point positioning显示文摘Precise Point Positioning(PPP) technology has developed into a potent instrument for geodetic positioning, ionospheric modeling, tropospheric atmospheric parameter detection, and seismic monitoring.As atmospheric reanalysis data products’ accuracy and spatiotemporal resolution have improved recently, it has become important to apply these products to obtain high-accuracy tropospheric delay parameters, like zenith tropospheric delay(ZTD) and tropospheric horizontal gradient. These tropospheric delay parameters can be applied to PPP to reduce the convergence time and to increase the accuracy in the vertical direction of the position. The European Centre for Medium-Range Weather Forecasts Reanalysis 5(ERA5) atmospheric reanalysis data is the latest product with a high spatiotemporal resolution released by the European Center for Medium-Range Weather Forecasts(ECMWF). Only a few researches have evaluated the application of ERA5 data to Global Navigation Satellite System(GNSS)PPP. Therefore, this study compared and validated the ZTD products derived from ERA5 data using ZTD values provided by 290 global International GNSS Service(IGS) stations for 2016-2017. The results indicated a stable performance for ZTD, with annual average bias and RMS values of 0.23 cm and 1.09 cm,respectively. Further, GNSS observations for one week in each of the four seasons(spring: DOY 92-98;summer: DOY 199-205;autumn: DOY 275-281;and winter: DOY 22-28) from 34 multi-GNSS experiments(MGEX) stations distributed globally in 2016 were considered to evaluate the performance of ERA5-derived tropospheric delay products in GNSS PPP. The performance of ERA5-enhanced PPP was compared with that of the two standard GNSS PPP schemes(without estimated tropospheric horizontal gradient and with estimated tropospheric horizontal gradient). The results demonstrated that ERA5-enhanced GNSS PPP showed no significant improvement in the convergence times in both the Eastern(E) and Northern(N) directions, while the average convergence time over four weeks in the vertical(U)direction improved by 53.3% and 52.7%, respectively(in the case of pngm station). The average convergence times for each week in the U direction of the northern and southern hemisphere stations indicated a decrease of 16.3%, 12.6%, 9.6%, and 9.1%, and 16.9%, 9.6%, 8.9%, and 14.5%, respectively.Regarding positioning accuracy, ERA5-enhanced PPP showed an improvement of 13.3% and 16.2% over the two standard PPP schemes in the U direction, respectively. No significant improvement in the positioning performance was observed in both the E and N directions. Thus, this study demonstrated the potential application of the ERA5 tropospheric parameters-augmented approach to Beidou navigation and positioning. | Liangke Huang Feifan Liu Lijie Guo Guiwen Lan Lv Zhou Cheng Wang Lilong Liu | 2023 | Geodesy and Geodynamics2023，14，5： | 0 |
| 20 | Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo显示文摘Background:Currently,direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds.Delivery of transcriptional factors may affect genome stability,while small-molecule compounds may require more evaluations when applied in vivo.Thus,a defined medium with only conventional growth factors or additives for cell culture is desirable for inducing neuronal trans-differentiation.Results:Here,we report that a defined medium(5C)consisting of basic fibroblast growth factor(bFGF),N2 supplement,leukemia inhibitory factor,vitamin C(Vc),andβ-mercaptoethanol(βMe)induces the direct conversion of somatic cells to cells with neuronal characteristics.Application of 5C medium converted mouse embryonic fibroblasts(MEFs)into TuJ+neuronal-like cells,which were capable of survival after being transplanted into the mouse brain.The same 5C medium could convert primary rat astrocytes into neuronal-like cells with mature electrophysiology characteristics in vitro and facilitated the recovery of brain injury,possibly by inducing similar conversions,when infused into the mouse brain in vivo.Crucially,5C medium could also induce neuronal characteristics in several human cell types.Conclusions:In summary,this 5C medium not only provides a means to derive cells with neuronal characteristics without viral transfection in vitro but might also be useful to produce neurons in vivo for neurodegenerative disease treatment. | Songwei He Yiping Guo Yixin Zhang Yuan Li Chengqian Feng Xiang Li Lilong Lin Lin Guo Haitao Wang Chunhua Liu Yi Zheng Chuanming Luo Qiang Liu Fuhui Wang Hao Sun Lining Liang Lingyu Li Huanxing Su Jiekai Chen Duanqing Pei Hui Zheng | 2015 | Cell Regeneration2015，4，1： | 0 |
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