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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | One-step RT-PCR protocols improve the rate of dengue diagnosis com- pared to two-step RT-PCR approaches显示文摘 | De Paula S O D Lima C D M Torres M P | 2004 | J Clin Virol2004，30，： | 1 |
| 3 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 4 | Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells显示文摘 | Scolastici C Alves D E Lima R O | 2007 | Toxicology in Vitro2007，21，5： | 1 |
| 5 | Single-mask microfabrication of aspherical optics using KOH anisotropic etching of Si显示文摘 | D W de Lima Monteiro O Akhzar-Mehr P M Sarro | 2003 | Opitcal Express2003，11，18： | 1 |
| 6 | Kinetics of sulphuric acid leaching of a zinc silicate calcine显示文摘 | Souza A D Pina P S Lima E V O | | 0，，3： | 1 |
| 7 | High-density inductively coupled plasma chemical vapor deposition of silicon nitride for solar cell application 显示文摘 | PARMA I O KIMA K LIMA D G | 2002 | Solar Energy Materials and Solar Cells2002，74，14： | 1 |
| 8 | The effect of the orientation of the acetabular and femoralcomponents on the range of motion of the hip at different head-neck ratios显示文摘 | D'LIMA D D URQUHART A G BUEHLER K O | 2000 | J Bone Joint Surg(Am)2000，82，3： | 1 |
| 9 | Oto- mycosis:a retrospective study显示文摘 | PONTES Z B SILVA A D LIMA EDE O | 2009 | Braz J Otorhinolar- yngol2009，75，： | 1 |
| 10 | Kinetic of sulphuric acidleaching of a zinc silicate calcine显示文摘 | Souza A D Pina P S Lima E V O | 2007 | Hydrometallurgy2007，89，： | 1 |
| 11 | Single-mask microfabrication of aspherical optics using KOH anisotropic etching of Si显示文摘 | Lima Monteiro D W Akhzar-Mehr O Sarro P M | 2003 | Optical Express2003，11，18： | 1 |
| 12 | Human papillomavirus genotype attribution in invasive cervical cancer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L Geraets DT Klaustermeier JE Lloveras B Tous S Felix A Bravo LE Shin HR Vallejos CS de Ruiz PA Lima MA Guimera N Clavero O Alejo M Llombart-Bosch A Cheng-Yang C Tatti SA Kasamatsu E Iljazovic E Odida M Prado R Seoud M Grce M Usubutun A Jain A Suarez GA Lombardi LE Banjo A Menéndez C Domingo EJ Velasco J Nessa A Chichareon SC Qiao YL Lerma E Garland SM Sasagawa T Ferrera A Hammouda D Mariani L Pelayo A Steiner I Oliva E Meijer CJ AlJassar WF Cruz E Wright TC Puras A Llave CL Tzardi M Agorastos T Garcia-Barriola V Clavel C Ordi J Andújar M Castellsagué X Sánchez GI Nowakowsld AM Bornstein J Mu(n)oz N Bosch FX Retrospective International Survey and HPV Time Trends Study Group | 2010 | Lancet Oncol2010，11，11： | 1 |
| 13 | Thermo-oxidative stability of mineral naphthenic insulating oils: combined effect of antioxidants and metal passivator显示文摘 | Rabelo N R C Lima D O Pinheiro T D | 2004 | Industrial & Engineering Chemistry Research2004，43，23： | 1 |
| 14 | Pharmacokineticsof extended-release dipyridamole following administrationthrough a gastrostomy tube:an open-label,case-control,two-centre study显示文摘 | Batista L M Crandell D Lima F O | 2010 | Clin-Drug-Investig2010，30，7： | 1 |
| 15 | Synthesis,characterization and thermal decomposition of tin(Ⅳ) dithiocarbamate derivatives single source precursors for tin sulfide powders显示文摘 | Menezes D C de Lima G M Porto A O | 2004 | Polyhedron2004，23，： | 1 |
| 16 | The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios显示文摘 | D'LIMA D D URQUHART A G BUEHLER K O | 2000 | J Bone Joint Surg ( Am)2000，82，3： | 1 |
| 17 | Single-mask microfabrication of a spherical optics using KOH anisotropic etching of Si显示文摘 | D W de Lima Monteiro O Akhzar-Mehr P M Sarro | 2003 | Opt Express2003，11，18： | 1 |
| 18 | Kinetics of sulphuric acid leaching of a zinc silicate calcine显示文摘 | Souza A D Pina P S Lima E V O | 2007 | Hydrometallurgy2007，89，34： | 1 |
| 19 | Biodegradability of bacterialsurfactants显示文摘 | Lima T M S Procópio L C Brand?o F D | 2011 | Biodegradation2011，22，3： | 1 |
| 20 | DC conductivity and dielectric permittivity of collagen-chitosan films显示文摘 | LIMA C G A de OLIVEIRA R S FIGUEIR(O) S D | 2006 | Materials Chemistry and Physics2006，99，23： | 1 |
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