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| 1 | All-optical computing based on convolutional neural networks显示文摘The rapid development of information technology has fueled an ever-increasing demand for ultrafast and ultralow-en-ergy-consumption computing.Existing computing instruments are pre-dominantly electronic processors,which use elec-trons as information carriers and possess von Neumann architecture featured by physical separation of storage and pro-cessing.The scaling of computing speed is limited not only by data transfer between memory and processing units,but also by RC delay associated with integrated circuits.Moreover,excessive heating due to Ohmic losses is becoming a severe bottleneck for both speed and power consumption scaling.Using photons as information carriers is a promising alternative.Owing to the weak third-order optical nonlinearity of conventional materials,building integrated photonic com-puting chips under traditional von Neumann architecture has been a challenge.Here,we report a new all-optical comput-ing framework to realize ultrafast and ultralow-energy-consumption all-optical computing based on convolutional neural networks.The device is constructed from cascaded silicon Y-shaped waveguides with side-coupled silicon waveguide segments which we termed“weight modulators”to enable complete phase and amplitude control in each waveguide branch.The generic device concept can be used for equation solving,multifunctional logic operations as well as many other mathematical operations.Multiple computing functions including transcendental equation solvers,multifarious logic gate operators,and half-adders were experimentally demonstrated to validate the all-optical computing performances.The time-of-flight of light through the network structure corresponds to an ultrafast computing time of the order of several picoseconds with an ultralow energy consumption of dozens of femtojoules per bit.Our approach can be further expan-ded to fulfill other complex computing tasks based on non-von Neumann architectures and thus paves a new way for on-chip all-optical computing. | Kun Liao Ye Chen Zhongcheng Yu Xiaoyong Hu Xingyuan Wang Cuicui Lu Hongtao Lin Qingyang Du Juejun Hu Qihuang Gong | 2021 | Opto-Electronic Advances2021，4，11： | 3 |
| 2 | Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p 15^INK4B, p 16^INK4A, and p57^KIP2 transcription显示文摘 | Qingping Zheng Hongjia Fan Zhenzhen Meng Lin Yuan Cuicui Liu You Peng Weiwei Zhao Lulu Wang Jing Li Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 3 | Moderate papain addition improves the physicochemical,microbiological,flavor and sensorial properties of Chouguiyu,traditional Chinese fermented fish显示文摘The objective of this study was to investigate the effect of papain on the physicochemical and microbiological properties,volatile compound profiles,and sensorial attributes of Chouguiyu.Papain was applied at a dose of 10,50,200,400 U/g fish.Results showed that papain addition improved the release of free amino acids,essential amino acids,eicosapentaenoi acid(EPA,C20:5n3),and docosapentenoic acid(DPA,C22:5n6),respectively.Lower biogenic amines content,higher the volatile compound concentrations and relative abundance of Lactobacillales were also observed.Further results showed that the papain dose group decreased the fermentation time from 10 to 7 days while good organoleptic quality was remained,especially in the 200 U/g dose group.The redundancy analysis(RDA)showed a high correlation between Lactobacillus and the key volatile compounds in the 200 U/g and 400 U/g groups,which indicated that Lactobacillus could contribute to the fatty flavor.In summary,proper papain addition(i.e.200 U/g or 400 U/g)could reduce biogenic amines contents and maintain acceptable sensorial properties of Chouguiyu in a shorter fermentation time. | Wenhuan Xu Cuicui Jiang Aoxue Liu Ruiqi Bao Wenqing Wang Zuoli Zhang Chaofan Ji Huipeng Liang Sufang Zhang Xinping Lin | 2022 | Food Bioscience2022，46，2： | 2 |
| 4 | Polyploidy Induction of Pteroceltis tatarinowii Maxim.显示文摘[Objective] This study was conducted to obtain tetraploid Pteroceltis tatarinowii Maxim. with excellent ornamental traits. [Method] The stem apex growing points of Pteroceltis tatarinowii Maxim. were treated with different concentrations of colchicine solution for different hours to figure out a proper method and obtain polyploids. [Result] The most effective induction was obtained by treatment with 0.6%-0.8% colchicine for 72 h with 34.2% mutation rate. Flow cytometry and chromosome observation of the stem apex growing point of P. tatarinowii Maxim. proved that the tetraploid plants were successfully obtained with chromosome number 2n =4x =36.[Conclusion] The result not only fills the blank of polyploid breeding of P. tatarinowii,but also provides an effective way to broaden the methods of cultivation of fastgrowing, high-quality, disease-resilience, new varieties of Pteroceltis. | Lin ZHANG Feng WANG Zhongkui SUN Cuicui ZHU Rongwei CHEN | 2015 | Agricultural Science & Technology2015，16，6： | 2 |
| 5 | Combination of two multiplex genome-edited soybean varieties enables customization of protein functional properties显示文摘Dear Editor,Soybean(Glycine max)is a major source of plant-based protein for people worldwide,providing a healthy,affordable,and environmentally friendly alternative to animal-based protein(Montgomery,2003).It has been estimated that there are currently over 12000 food products that contain soy protein(Montgomery,2003).Different food applications of soy protein require distinct properties that affect its function and sensory features.For instance,the sensory quality of soymilk is significantly affected by protein emulsibility,whereas tofu quality is determined by protein-gelling ability(Kinsella,1979). | Mengyan Bai Cuicui Yuan Huaqin Kuang Qian Sun Xinchen Hu Luning Cui Wenxin Lin Chunyan Peng Peng Yue Shikui Song Zebin Guo Yuefeng Guan | 2022 | Molecular Plant2022，15，7： | 1 |
| 6 | Finite-time control of discrete-time systems with time-varying exogenous disturb- anee显示文摘 | ZHU Lin SHEN Yanjun LI Cuicui | 2009 | Comraunieation in Nonlinear Science and Numerical Simulation2009，14，： | 1 |
| 7 | Finite-time control of discrete-time systems with time-varying exogenous disturbance显示文摘 | Lin Zhu Yanjun Shen Cuicui Li | 2009 | Communications in Nonlinear Science and Numerical Simulation2009，14，： | 1 |
| 8 | Finite-time control of dis-crete-time systems with time-varying exogenous disturbance 显示文摘 | Zhu Lin Shen Yanjun Li Cuicui | 2009 | Communications in Nonlinear Science and Numerical Simulation2009，141，： | 1 |
| 9 | Prokaryotic Expression of Glycoprotein Gene of Infectious Hnematopoietic Necrosis Virus and Polyclonal Antibody Preparation显示文摘[Objective]The aim is to perform prokaryotic expression of the glycoprotein gene of infectious hnematopoietic necrosis virus and polyclonal antibody preparation. [Methods]Glycoprotein gene( G) of infectious hematopoietic tissue( IHNV) was synthesized,cloned to prokaryotic expression system pET-30a vector,yielding the recombinant plasmid pET-30a-IHNV-G. The yielded pET-30a-IHNV-G was transformed into E. coli strain BL21( DE3) plySs. [Results] SDSPAGE and Western blot results showed that protein G successfully expressed in E. coli at 37 ℃,1 mmol /L IPTG induction for 4 h. The molecular weight of fusion G protein was 57 KD. The polyclonal antibody was prepared by immunizing mice with the product of gel purification. ELISA analysis showed that the serum titer reached 1∶10 000. [Conclusion]The expressed G protein and the serum with polyclonal antibody obtained in this study provided the theoretical basis for the development of IHNV vaccine and detection of colloidal gold test strip. | Liu Xueguang Zheng Huaidong Guo Xinshuo Luo Jin Lin Cuicui Wang Qiuyu | 2014 | Animal Husbandry and Feed Science2014，6，2： | 0 |
| 10 | Bone Marrow-derived Mesenchymal Stem Cells Promote Microglia/Macrophage M2 Polarization and Enhance Neurogenesis in the Acute and Chronic Stages after Ischemic Stroke显示文摘Background:Ischemic stroke has been regarded as a major cause of disability and death around the world due to limited effective therapies.Accumulating evidence have shown that although microglia are polarized to an anti-inflammatory M2 phenotype in the early stage of ischemia,they transform progressively into a proinflammatory M1 phenotype.Bone marrow-derived mesenchymal stem cells(BMSCs)may be used to treat ischemic injury through regulating the poststroke inflammatory response.However,the mechanism by which BMSCs can treat ischemic stroke remains unclarified.Objective:This study aimed to investigate whether BMSCs shift M1-to-M2 phenotype transformation of mi-croglia/macrophages and enhance neurogenesis in a rat transient middle cerebral artery occlusion(tMCAO)model.Methods:Ninety-minute tMCAO was applied to the rats,followed by reperfusion.BMSCs were transplanted into the rats via intravenous injection at 24 h after tMCAO.After being randomly divided into the sham group,the MCAO group,and the BMSCs group,the rats’behavior was assessed at 1,3,7,and 14 days following tM-CAO.qRT-PCR,double-immunofluorescence staining,and Western blot were performed at 3 and 14 days after tMCAO to determine M1/M2 polarization of microglia/macrophages.Neurogenesis was examined by double-immunofluorescence staining at 14 days after tMCAO.Expression of brain-derived neurotrophic factor(BDNF)was measured on the protein level by immunofluorescence staining at 3 and 14 days after tMCAO.Results:We found that BMSCs treatment promoted the recovery of neurological function after tMCAO,inhibited the expression of TNF��,iNOS and CD16/32,which are markers of M1 microglia/macrophage,and enhanced the expression of IL10,TGF��and CD206 that are markers of M2 microglia/macrophage.Moreover,BMSCs treatment promoted neurogenesis and M2-derived BDNF expression after tMCAO.Conclusion:It is indicated by the results that BMSCs modulate neuroinflammation and enhance neurogenesis,which could be due to transforming microglia/macrophages from the M1 polarization state towards M2 in a rat tMCAO model. | Yan Yang Hangyang Bao Huaqian Jin Lin Li Yan Fang Cuicui Ren Jun Wang Lisheng Chu | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，4： | 0 |
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