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| 1 | Block sulfonated poly(ether ether ketone) s (SPPEEK) iononmers with high ion-exchange capacities for proton exchange membranes显示文摘 | Zhao Chengji Lin Haidan Shao Ke | 2006 | J Power Sources2006，162，： | 1 |
| 2 | Covalently cross-linked proton exchange membranes based on sulfonated poly(arylene ether ketone) and polybenzimidazole oligomer显示文摘 | Chengji Zhao Haidan Lin Miaomiao Han Hui Na | 2010 | Journal of Membrane Science2010，353，： | 1 |
| 3 | Nafion-assisted cross-linking of sulfonated poly(arylene ether ketone) bearing carboxylic acid groups and their composite membranes for fuel cells显示文摘 | Haidan Lin Chengji Zhao Hui Na | 2009 | Journal of Power Sources2009，，11： | 1 |
| 4 | Low water swelling and high methanol resistant proton exchange membrane fabricated by cross-linking of multilayered polyelectrolyte complexes显示文摘 | Haidan Lin Chengji Zhao Wenjia Ma Hongtao Li Hui Na | 2009 | Journal of Membrane Science2009，，1： | 1 |
| 5 | Prominent genetic structure across native and introduced ranges of Pluchea indica, a mangrove associate, as revealed by microsatellite markers显示文摘阔苞菊(Pluchea indica)是一种红树林伴生植物,以其在原产地的药用特性和部分引入地的入侵性而闻名。本研究旨在评估阔苞菊在其分布范围内遗传变异的地理分布,确定影响其遗传结构的因素,并利用这些信息对阔苞菊在原产地和引入地的保护和管理策略提出建议。我们以来自阔苞菊原产地(亚洲)和引入地(美国)的31个种群共348个个体的15个核微卫星位点数据对阔苞菊的遗传多样性和种群结构进行了评估。在大尺度范围以及局部区域两种空间尺度上对阔苞菊遗传变异的空间格局进行了探讨,并验证了以下假说:地理距离和自然地理屏障将影响种群结构并在空间尺度上产生不同程度的分化。研究结果表明,与所研究区域内的其它红树林物种的遗传多样性参数相比,我们发现阔苞菊在种群水平上具有相对较高的遗传多样性以及在物种水平上具有明显的遗传分化。大多数阔苞菊种群显示杂合子缺失,这主要是由于近交和有限的基因流所导致。在较大空间尺度上进行的种群结构分析显示,该物种自然分布范围内存在两个主要遗传谱系,中国的种群与印度尼西亚、马来西亚、新加坡、泰国、柬埔寨和菲律宾的种群分别属于不同的谱系,而美国的种群可能来自于中国的谱系。此外,在局部区域范围内也同样检测到种群之间的遗传分化。大部分阔苞菊种群所表现出的遗传瓶颈效应强调了其具有本地灭绝的风险。基于上述研究结果,我们建议采用原位保护策略对阔苞菊进行管理,并开展对优先保护种群的保护行动以维持遗传多样性。 | Yuting Lin Achyut Kumar Banerjee Haidan Wu Fengxiao Tan Hui Feng Guangwen Tan Wuxia Guo Yelin Huang | 2020 | Journal of Plant Ecology2020，13，3： | 0 |
| 6 | FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth显示文摘Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FBXW7β,a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC,is an E3 ligase of fatty acid synthase(FASN).Cancer-specific FBXW7βmutations that could not degrade FASN can lead to sustained lipogenesis in CRC.COP9 signalosome subunit 6(CSN6),an oncogenic marker of CRC,increases lipogenesis via interacting with and stabilizing FASN.Mechanistic studies show that CSN6 associates with both FBXW7βand FASN,and antagonizes FBXW7β’s activity by enhancing FBXW7βautoubiquitination and degradation,which in turn prevents FBXW7β-mediated FASN ubiquitination and degradation,thereby regulating lipogenesis positively.Both CSN6 and FASN are positively correlated in CRC,and CSN6-FASN axis,regulated by EGF,is responsible for poor prognosis of CRC.The EGF-CSN6-FASN axis promotes tumor growth and implies a treatment strategy of combination of orlistat and cetuximab.Patient-derived xenograft experiments prove the effectiveness of employing orlistat and cetuximab combination in suppressing tumor growth for CSN6/FASN-high CRC.Thus,CSN6-FASN axis reprograms lipogenesis to promote tumor growth and is a target for cancer intervening strategy in CRC. | Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 7 | Continuously released Zn^(2+)in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties显示文摘Long-term nonunion of bone defects has always been a major problem in orthopedic treatment.Artificial bone graft materials such as Poly(lactic-co-glycolic acid)/β-tricalcium phosphate(PLGA/β-TCP)scaffolds are expected to solve this problem due to their suitable degradation rate and good osteoconductivity.However,insufficient mechanical properties,lack of osteoinductivity and infections after implanted limit its large-scale clinical application.Hence,we proposed a novel bone repair bioscaffold by adding zinc submicron particles to PLGA/β-TCP using low temperature rapid prototyping 3D printing technology.We first screened the scaffolds with 1 wt%Zn that had good biocompatibility and could stably release a safe dose of zinc ions within 16 weeks to ensure long-term non-toxicity.As designed,the scaffold had a multi-level porous structure of biomimetic cancellous bone,and the Young’s modulus(63.41±1.89 MPa)and compressive strength(2.887±0.025 MPa)of the scaffold were close to those of cancellous bone.In addition,after a series of in vitro and in vivo experiments,the scaffolds proved to have no adverse effects on the viability of BMSCs and promoted their adhesion and osteogenic differentiation,as well as exhibiting higher osteogenic and anti-inflammatory properties than PLGA/β-TCP scaffold without zinc particles.We also found that this osteogenic and anti-inflammatory effect might be related to Wnt/β-catenin,P38 MAPK and NFkB pathways.This study lay a foundation for the follow-up study of bone regeneration mechanism of Zn-containing biomaterials.We envision that this scaffold may become a new strategy for clinical treatment of bone defects. | Chunxu Li Fengbo Sun Jingjing Tian Jiahao Li Haidan Sun Yong Zhang Shigong Guo Yuanhua Lin Xiaodan Sun Yu Zhao | 2023 | Bioactive Materials2023，，6： | 0 |
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