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您的检索式：作者名="Lin Maoguo"
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| 1 | Exosomes from adipose-derived mesenchymal stem cells promote survival of fat grafts by regulating macrophage polarization via let-7c显示文摘The rate of fat graft survival is a critical aspect of successful surgery and has been a matter of concern for over 20 years.Owing to their anti-inflammatory effects and regenerative property,adipose-derived mesenchymal stem cells(AD-MSCs)have been adapted for clinical application in fat grafting,although the mechanism underlying their action remains unclear.Recently,exosomes derived from MSCs were suggested as a better alternative,and these exosomes have also been applied in diverse clinical therapies.Accumulating evidence suggests that MSCs modulate macrophage differentiation via exosome secretion,and the connection between macrophage regulation and the rate of fat graft survival has been established.Here,we identified that let-7c,the key factor in the regulatory process,is shuttled by AD-MSC-derived exosomes to downregulate the transcription factor CCAAT/enhancer-binding protein(C/EBP)-δ.The downregulation of C/EBP-δresulted in the attenuation of pro-inflammatory M1 macrophages and elevation of anti-inflammatory M2 macrophages.These results suggest that AD-MSC-derived exosomes promote the survival of fat grafts by regulating macrophage polarization via let-7c.This is the first study to elucidate the mechanism underlying the promotion of the fat graft survival rate by AD-MSCs and to evaluate the immunotherapeutic potential of AD-MSC-derived exosomes in fat grafting. | Xiaoyan Hao Yuan Guo Rui Wang Xueyuan Yu Lin He Maoguo Shu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 2 | Niching clonal selection algorithm for multimodal function optimization显示文摘 | LIN Hao GONG Maoguo SUN Yifei | 2006 | Lecture Notes in Computer Science2006，4221，： | 1 |
| 3 | MgFe-layered double hydroxide modified electrodes for direct electron transfer of heme proteins显示文摘 | Lin Maoguo Ji Huiqin Wang Yinling | 2012 | Biosens Bioelectron2012，38，1： | 1 |
| 4 | Construction of Amperometric Glucose Biosensor based on In-situ Fabricated Hierarchical Mesomacroporous SiO2 Modified Au Film Electrodes显示文摘Gold nanoparticles(GNPs) modified hierarchical meso-macroporous(HMMP) SiO_2 layer on the surface of Au film electrode was developed as a novel enzyme immobilization matrix for biosensors construction.HMMP SiO_2-Au bilayer film electrodes were in-situ fabricated with magnetron sputtering process and templating method.The as-prepared HMMP SiO_2 films were characterized by SEM,TEM,and cyclic voltammetry(CV).The modified layer of HMMP SiO_2 has interconnected pore channels,and the sizes of macropores and mesopores are about 330 nm and 9 nm,respectively.The HMMP SiO_2 modified gold film electrodes not only have no diffusion barrier for electrochemical probes,but also exhibit good electrochemical properties.In addition,the activity and stability of the immobilized enzyme can be commendably retained in HMMP SiO_2.The biosensor exhibits an excellent bioelectrocatalytic response to glucose with a linear range of 1.0×10^(-4)M-1.0×10^(-2)M,high sensitivity of 18.0 μA·m M^(-1)·cm^(-2),as well as good reproducibility and stability. | 唐敏 LIN Xinhua LI Maoguo LI Jie NI Lin YIN Shiping | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 0 |
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