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| 1 | Large-area growth of ultra-high-density single-walled carbon nanotube arrays on sapphire surface显示文摘获得高密度的、大区域的围单人赛的碳 nanotube (SWNT ) 的可伸缩的途径穿的 A 为在实际电子设备认识到 SWNT 的完整的潜力是必要的;这仍然是大挑战。这里,我们由联合特洛伊催化剂在蓝宝石表面上为 ultra-high-density SWNT 数组的大区域的生长报导一个改进合成方法(免除了底层,保证超离频密度) 与瞬间 nanoparticles (在表面上装载了,稳定释放特洛伊催化剂) 作为合作催化剂。稠密、非常排列的 SWNT 盖住全部底层,本地密度象 160 tubes/m 一样高。在如此的数组上造的地效果晶体管(联邦货物税) 在排水管来源电压给了 488 A/m 的产量电流密度(V ds )= 门来源电压(V gs )=2 V,相应于在传导力上每 244 S/m 的宽度。这些结果在 SWNT 的控制结构的生长证实特洛伊瞬间催化剂的潜在的应用的宽范围。 | Lixing Kang Yue Hu Hua Zhong Jia Si Shuchen Zhang Qiuchen Zhao Jingjing Lin Qingwen Li Zhiyong Zhang Lianmao Peng Jin Zhang | 2015 | Nano Research2015，8，11： | 5 |
| 2 | Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters显示文摘Dear Editor,Different from normal differentiated cells,metabolic reprogramming was spotted in cancer cells,due to increased demand for energy and macromolecule synthesis during their rapid proliferation(Hanahan and Weinberg,2011;Pavlova and Thompson,2016).Most cancer cells prefer anaerobic glycolysis even with oxygen in the environment due to its higher speed to produce macromolecular materials required for biosynthesis(Vander Heiden et al.,2009;DeBerardinis and Chandel,2016).But to compensate for the lower efficiency of anaerobic glycolysis in producing ATP,these cancer cells demand much higher glucose supply(Warburg,1956;Vander Heiden et al.,2009).These metabolic characteristics point to the huge demand of cancer cells for carbohydrate substrates,which creates the possibility of treating tumors by exploiting this feature(Patra et al.,2013;DeBerardinis and Chandel,2016). | Meng Gao Jian Huang Xin Jiang Yafei Yuan Huanhuan Pang Shuchen Luo Nan Wang Chengbo Yao Zuwan Lin Debing Pu Shuo Zhang Pengcheng Sun Zhuoyi Liu Yu Xiao Qian Wang Zeping Hu Hang Yin | 2020 | Protein & Cell2020，11，6： | 2 |
| 3 | Application of grey model to ward runoff forecasting 显示文摘 | Yu Paoshan Cehn Chiajung Chen Shiannjong Lin Shuchen | 2001 | Journal of The American Water Resources Association2001，37，1： | 1 |
| 4 | Fractal of rainfall: identification of temporal scaling law 显示文摘 | Lin Shuchen Liu Changling Lee Tzongyeang | 1997 | Fractals1997，7，2： | 1 |
| 5 | Aqueous self-assembly and surface-functionalized nanodots for live cell imaging and labeling显示文摘Nanoparticles 为 bioimaging 和 biolabeling 应用有庞大的潜力,在哪个常规有机性地基于荧光灯标签降级并且没能提供长期的追踪。因此,途径的开发做荧光灯可溶的探针水和标签房间有效为很生物的应用程序是合乎需要的。这里,我们为蛋白质标记作为一根探针从 3-aminopropyltriethoxysilane (APTES ) 在自我装配的 nanodots (沙) 的制造和描述上报导。我们显示出那荧光灯沙探针在水的环境展出明亮的光致发光和 biocompatibility。在用 hepatoma 房间线标记的蛋白质和糖类的 vitro 成像选择用分别地与卵白素和半乳糖结合的 biocompatible 沙被表明。Cytotoxicity 测试证明结合的沙粒子在房间增长上有可以忽略的效果。不同于要求 multistep 处理完成柔韧的表面 functionalization 并且开发灵活 bioconjugation 策略的另外的合成系统,我们的结果为创造多色表明这个一步舞沙制造方法的通用性荧光灯有定制的功能,有效排放,以及优秀 biocompatibility 的探针,为宽广生物使用要求了。 | Mei-Lang Kung Pei-Ying Lin Chiung-Wen Hsieh Shuchen Hsieh | 2014 | Nano Research2014，7，8： | 0 |
| 6 | Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia显示文摘Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers,best exemplified by loss-offunction mutations in genes encoding components of the TGF-βsignaling pathway in colorectal and pancreatic cancers.Alternatively,gain-of-function oncogene mutations can also disrupt antiproliferative TGF-βsignaling.However,the molecular mechanisms underlying oncogene-induced modulation of TGF-βsignaling have not been extensively investigated.Here,we show that the oncogenic BCR-ABL1 of chronic myelogenous leukemia(CML)and the cellular ABL1 tyrosine kinases phosphorylate and inactivate Smad4 to block antiproliferative TGF-βsignaling.Mechanistically,phosphorylation of Smad4 at Tyr195,Tyr301,and Tyr322 in the linker region interferes with its binding to the transcription co-activator p300/CBP,thereby blocking the ability of Smad4 to activate the expression of cyclin-dependent kinase(CDK)inhibitors and induce cell cycle arrest.In contrast,the inhibition of BCR-ABL1 kinase with Imatinib prevented Smad4 tyrosine phosphorylation and re-sensitized CML cells to TGF-β-induced antiproliferative and pro-apoptotic responses.Furthermore,expression of phosphorylation-site-mutated Y195F/Y301F/Y322F mutant of Smad4 in Smad4-null CML cells enhanced antiproliferative responses to TGF-β,whereas the phosphorylation-mimicking Y195E/Y301E/Y322E mutant interfered with TGF-βsignaling and enhanced the in vivo growth of CML cells.These findings demonstrate the direct role of BCR-ABL1 tyrosine kinase in suppressing TGF-βsignaling in CML and explain how Imatinib-targeted therapy restored beneficial TGF-βanti-growth responses. | Lijing Wang Shuchen Gu Fenfang Chen Yi Yu Jin Cao Xinran Li Chun Gao Yanzhen Chen Shuchong Yuan Xia Liu Jun Qin Bin Zhao Pinglong Xu Tingbo Liang Hongyan Tong Xia Lin Xin-Hua Feng | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 7 | Fine-needle aspiration for periprosthetic fluid removal after implantation of a remote internal-port tissue expander显示文摘Background:Use of internal filling ports in tissue expander–based reconstructions are advantageous because of easier self-care,lower infection rates,and fewer instances of capsule formation.The appearance of periprosthetic fluid accumulation after internal-port tissue expander implantation is a common complication that warrants treatment.In this study,we introduced a noninvasive method using fine-needle aspiration(FNA)to remove fluids accumulated after implantation of a remote internal-port tissue expander.Methods:In this study,245 patients who underwent implantation of remote internal-port tissue expanders in our hospital from July 1,2012,to July 1,2019,were included and divided into two groups.In the control group,patients underwent tissue expander implantation before July 1,2016,and large quantities of fluids were removed with surgical aspiration procedures in most cases.In the FNA group,the patients underwent implantation after July 1,2016,and large quantities of fluids were removed first with the FNA procedure.Patients’demographic data,indications for FNA application,and related complications were collected and analyzed.Results:Overall,395 expanders were placed in 245 patients.Postoperative management was similar in both groups.Fluids were managed with 23 expanders in the control group and with 31 expanders in the FNA group.There was no difference in the fluid aspiration rate between the two groups.The surgical aspiration rate was 11.1%(23/208)in the control group.The success rate of FNA was 90.3%(28/31).In the FNA group,the surgical aspiration rate was 1.6%(3/187),which was significantly lower than that in the control group.There were no significant differences in complications between the two groups.Conclusion:FNA can be used for periprosthetic fluid removal after the implantation of a remote internal-port tissue expander in most cases.This method is more convenient and safer than surgical aspiration for the postoperative management of internal-port tissue expander implantation. | Xifeng Lin Shuchen Gu Yashan Gao Hainan Zhu Bin Gu Feng Xie Qingfeng Li Tao Zan Haizhou Li | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，3： | 0 |
| 8 | Quantitative monitoring and mutations of ctDNA before and after non-small cell lung cancer radical surgery显示文摘Objective The aim of this study was to study the quantitative expression of circulating tumour DNA(ctDNA) in patients with non-small cell lung cancer(NSCLC) before and after radical operation and to explore the correlation between gene mutations in non-small cell lung cancer tissues and those in ctDNA.Methods We randomly assigned 5 NSCLC patients from the Department of Thoracic Surgery of Fujian Medical University Union Hospital. All the patients had undergone radical surgery. Venous blood samples were collected from the 5 NSCLC patients at two time points(before the operation and 21–37 days after the operation) for monitoring ctDNA levels. This was done by isolating plasma from venous blood using high velocity centrifugation, extracting DNA from the plasma using the QIAamp Circulating Nucleic Acid kit, and then quantifying the ctDNA levels. The results were analyzed using the Wilcoxon Rank Sum Test. Moreover, the ctDNA levels were compared with those of carcinoembryonic antigen(CEA), which was detected simultaneously with the ctDNA. Then, DNA samples from the tumor tissues and peripheral blood cells and ctDNA were sequenced using the Hiseq2000 sequencing platform(Illumina) and the mutant genes were screened out. Mutations that occurred within the tumor tissues were used as positive control, whereas those found in the pre-operative blood cells were used as a negative control. Based on the mutational analysis of ctDNA genes, a total of 508 cancer-related genes were screened. Results The median values of the pre-and post-operative ctDNA levels in the 5 patients with NSCLC were 0.612(0.518–0.876) and 0.430(0.372–0.612) ng/μL, respectively. There was a significant difference between the two groups(P < 0.05). The pre-operative CEA level was slightly higher than the post-operative level(P > 0.05). In one of the cases, LC tissues showed multiple mutations, consistent with pre-operative ctDNA. Moreover, isogenic mutations of the same type were not detected in post-operative ctDNA or peripheral blood cells. Conclusion Mutations found in the lung cancer(LC) ctDNA gene were consistent with the mutation type of LC tissue. Hence, the quantitative and qualitative analysis of ctDNA is a promising novel molecular biomarker for the evaluation of tumor burden changes in NSCLC. | Xiangqi Chen Tingyan Lin Zhisen Gao Jiangjiang Xu Rui Feng Sheng Yang Shuchen Chen Mingqiang Kang | 2019 | Oncology and Translational Medicine2019，5，3： | 0 |
| 9 | Brain-targeted drug delivery assisted by physical techniques and its potential applications in traditional Chinese medicine显示文摘The blood-brain barrier(BBB)constitutes a major obstacle to effective delivery of drugs to the brain.Recent technological advances have led to improvements in brain-targeted drug delivery.In this review,we summarize existing technologies for efficient drug delivery across the BBB.We discuss the mechanisms of current BBB-based drug delivery strategies and introduce prospects for application in braint-argeted delivery of traditional Chinese medicine.We highlight the use of physical techniques for brain-targeted drug delivery,including electroporation,ultrasound,magnetophoresis,microneedles,microwaves,and laser.The characteristics of these techniques and relevant studies employing these approaches are discussed.In general,microneedles,lasers,ultrasound,electroporation,magnetophoresis,and microwaves are effective for drug delivery across the BBB.Notably,the synergistic effects of multiple approaches are superior to the additive effects of each technique in isolation.Our review provides guidance for the practical application of brain-targeted drug delivery techniques in an efficient and safe manner. | Yunbo Sun Lina Du Meiyan Yang Qi Li Xueli Jia Qian Li Lin Zhu Yuanyuan Zhang Yijing Liu Shuchen Liu | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 0 |
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