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| 1 | Characterization of gold/PMMA hybrid nanomaterials synthesized by hard X-ray synchrotron radiation显示文摘In this study, new types of hybrid gold poly(methyl methacrylate) (PMMA) nanomaterials are synthe-sized. Both PMMA spheres coated with gold nanoparticles and gold nanoparticles coated with PMMA can be synthesized using different ratios of HAuCl 4 and MMA precursors, by exposing the mixtures to hard X-ray synchrotron radiation without the use of a reducing agent. According to the photochemical mechanism, gold nanoparticles will precipitate from a solution of HAuCl 4 on exposure to synchrotron radiation, followed by the synthesis of PMMA by the polymerization of MMA monomers. These reactions can result in the formation of two different types of new hybrid nanomaterials. When a 1:1 volume ratio of HAuCl 4 to MMA is used, we obtain PMMA spheres coated with gold nanoparticles. When a 10:1 ratio of HAuCl 4 and MMA is used, we obtain gold nanoparticles coated with PMMA. The hybrid gold/PMMA nanostructures are characterized by transmission electron microscopy, elemental analysis, dynamic-light scattering analysis, gel permeation chromatography and Raman spectroscopy. The hybrid nanomaterials have potential application in the fields of biosensors and drug delivery. | Hueywen Liou Weijen Liou Hongming Lin Yeukuang Hwu Wenchang Chen | 2010 | Particuology2010，8，3： | 1 |
| 2 | Synthesis of titanium nitride thin films deposited by a new shielded arc ion plating显示文摘 | Yanhui Zhao Guoqiang Lin Jinquan Xiao Wenchang Lang Chuang Dong Jun Gong Chao Sun | 2011 | Applied Surface Science2011，，13： | 1 |
| 3 | Risky asset allocation and con- sumption rule in the presence of background risk and insurance markets 显示文摘 | Lin Wenchang Lu J | 2012 | Insurance: Mathematics and E- conomics2012，50，1： | 1 |
| 4 | Intronic microRNAs: discovery and biological implications 显示文摘 | Li Sungchou Tang Petrus Lin Wenchang | 2007 | DNA Cell Biol2007，26，4： | 1 |
| 5 | Cadmium exerts toxic effects on ovarian steroid hormone release in rats显示文摘 | Wenchang Zhang Fen Pang Yaqing Huang Ping Yan Wei Lin | 2008 | Toxicology Letters2008，，1： | 1 |
| 6 | An institutional analysis of the new product development process of small and medium enterprises (SMEs) in China, Hong Kong and Taiwan显示文摘 | Wai - sum Siu Tingling Lin Wenchang Fang Zhi Chao Liu | 2006 | Indus- trial Marketing Management2006，35，3： | 1 |
| 7 | PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis显示文摘Glaucoma is the leading cause of irreversible blindness worldwide.In the pathogen-esis of glaucoma,activated microglia can lead to retinal ganglion cells(RGCs)apoptosis and death,however,the molecular mechanisms remain largely unknown.We demonstrate that phospholipid scramblase 1(PLSCR1)is a key regulator promoting RGCs apoptosis and their clearance by microglia.As evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension(AOH)mouse model,overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane,as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and death.These damages were effectively attenuated by PLSCR1 inhibition.In the AOH model,PLSCR1 led to an increase in M1 type microglia activation and retinal neuroinflammation.Upregulation of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated microglia.Taken together,our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases. | Jingyi Luo Qing Lian Deliang Zhu Minglei Zhao Tingfang Mei Bizhi Shang Zeqiu Yang Chujun Liu Wenchang Xu Lan Zhou Keling Wu Xinqi Liu Yuhua Lai Fuxiang Mao Weihua Li Chengguo Zuo Kang Zhang Mingkai Lin Yehong Zhuo Yizhi Liu Lin Lu Ling Zhao | 2023 | Genes & Diseases2023，10，4： | 0 |
| 8 | Noise Pollution Reduction through a Novel Optimization Procedure in Passive Control Methods显示文摘This paper proposes a novel optimization framework in passive control techniques to reduce noise pollution.The geometries of the structures are represented by Catmull-Clark subdivision surfaces,which are able to build gap-free Computer-Aided Design models and meanwhile tackle the extraordinary points that are commonly encountered in geometricmodelling.The acoustic fields are simulated using the isogeometric boundary elementmethod,and a density-based topology optimization is conducted to optimize distribution of sound-absorbing materials adhered to structural surfaces.The approach enables one to perform acoustic optimization from Computer-Aided Design models directly without needingmeshing and volume parameterization,thereby avoiding the geometric errors and time-consuming preprocessing steps in conventional simulation and optimization methods.The effectiveness of the present method is demonstrated by three dimensional numerical examples. | Haojie Lian Leilei Chen Xiao Lin Wenchang Zhao Stephane P.A.Bordas Mingdong Zhou | 2022 | Computer Modeling in Engineering & Sciences2022，，4： | 0 |
| 9 | Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis显示文摘The conventional immunoadjuvants in vaccine have weak effect on stimulating antigen presentation and activating anti-tumor immunity.Unexpectedly,we discovered that non-pathogenic Sendai virus(SeV)could activate antigen-presenting cells(APCs)represented by dendritic cells(DCs).Here,we designed an injectable SeV-based hydrogel vaccine(SHV)to execute multi-channel recruitment and stimulation of DCs for boosting the specific immune response against tumors.After the release of the NIR-triggered antigens from tumor cells,dendritic cells around the vaccine efficiently transport the antigens to lymph nodes and present them to T lymphocytes,thereby inducing systemic anti-tumor immune memory.Our findings demonstrated that the SHV with excellent universality,convenience and flexibility has achieved better immune protection effects in inhibiting the occurrence of melanoma and breast cancer.In conclusion,the SHV system might serve as the next generation of personalized anti-tumor vaccines with enhanced features over standard vaccination regimens,and represented an alternative way to suppress tumorigenesis. | Bin Zheng Wenchang Peng Lin Gan Mingming Guo Shuchao Wang Xiao-Dong Zhang Dong Ming | 2021 | Bioactive Materials2021，6，11： | 0 |
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