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您的检索式：作者名="Lin Yuezhi"
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| 1 | Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels显示文摘Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue engineering.In particular,the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue repair.Here,a novel design of an integral bilayer scaffold combined with a photocurable silk sealant for osteochondral repair is reported.First,we fabricated a bilayer silk scaffold with a cartilage layer resembling native cartilage in surface morphology and mechanical strength and a BMP-2-loaded porous subchondral bone layer that facilitated the osteogenic differentiation of BMSCs.Second,a TGF-β3-loaded methacrylated silk fibroin sealant(Sil-MA)exhibiting biocompatibility and good adhesive properties was developed and confirmed to promote chondrocyte migration and differentiation.Importantly,this TGF-β3-loaded Sil-MA hydrogel provided a bridge between the cartilage layer of the scaffold and the surrounding cartilage and then guided new cartilage to grow towards and replace the degraded cartilage layer from the surrounding native cartilage in the early stage of knee repair.Thus,osteochondral regeneration and superior lateral integration were achieved in vivo by using this composite.These results demonstrate that the new approach of marginal sealing around the cartilage layer of bilayer scaffolds with Sil-MA hydrogel has tremendous potential for clinical use in osteochondral regeneration. | Xiaolin Wu Mingliang Zhou Fei Jiang Shi Yin Sihan Lin Guangzheng Yang Yuezhi Lu Wenjie Zhang Xinquan Jiang | 2021 | Bioactive Materials2021，6，11： | 7 |
| 2 | High-Efficiency Rescue of Equine Infectious Anemia Virus from a CMV-Driven Infectious Clone显示文摘Dear Editor,Equine infectious anemia virus(EIAV)belongs to the macrophage-tropic lentiviruses family and infects mainly equines,including horses,donkeys and mules.EIAV shares many similar characteristics in its viral biology and host-virus immune regulation with other lentiviruses,such as human immunodeficiency virus type 1(HIV-1)and simian immunodeficiency virus(SIV),and has been accepted as a model for the study of other lentiviruses,especially HTV-1(Craigo and Montelaro 2013).Specifically,in the 1970s,Chinese scientists developed an attenuated EIAV vaccine and by using this vaccine,China has successfully controlled EIAV prevalence.This vaccine provides a meaningful reference for lentivirus research(Wang et al.2016). | Xue-Feng Wang Bowen Bai Yuezhi Lin Ting Qi Cheng Du Mingxin Song Xiaojun Wang | 2019 | Virologica Sinica2019，34，6： | 3 |
| 3 | In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safely of an atten- uated equine infectious anemia virus (EIAV) vaccine 显示文摘 | Ma Jian Jiang Cenggang Lin Yuezhi | 2009 | Arch Virol2009，154，5： | 1 |
| 4 | Equine Viperin Restricts Equine Infectious Anemia Virus Replication by Inhibiting the Production and/or Release of Viral Gag,Env,and Receptor via Distortion of the Endoplasmic Reticulum显示文摘 | Yandong Tang Lei Na Chunhui Zhu Nan Shen Fei Yang Xianqiu Fu Yuhong Wang Lihua Fu Jiayi Wang Yuezhi Lin Xuefeng Wang Xiaojun Wang Jianhua Zhou Chengyao Li | 2014 | J Virol2014，88，12： | 1 |
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