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| 1 | pH modeling for maximum dissolved organic matter removal by enhanced coagulation显示文摘Correlations between raw water characteristics and pH after enhanced coagulation to maximize dissolved organic matter(DOM) removal using four typical coagulants(FeCl3,Al2(SO4)3,polyaluminum chloride(PACl) and high performance polyaluminum chloride(HPAC)) without pH control were investigated.These correlations were analyzed on the basis of the raw water quality and the chemical and physical fractionations of DOM of thirteen Chinese source waters over three seasons.It was found that the final pH after enhanced coagulation for each of the four coagulants was in?uenced by the content of removable DOM(i.e.hydrophobic and higher apparent molecular weight(AMW) DOM),the alkalinity and the initial pH of raw water.A set of feed-forward semi-empirical models relating the final pH after enhanced coagulation for each of the four coagulants with the raw water characteristics were developed and optimized based on correlation analysis.The established models were preliminarily validated for prediction purposes,and it was found that the deviation between the predicted data and actual data was low.This result demonstrated the potential for the application of these models in practical operation of drinking water treatment plants. | Jiankun Xie Dongsheng Wang John van Leeuwen Yanmei Zhao Linan Xing Christopher W. K. Chow | 2012 | Journal of Environmental Sciences2012，24，2： | 5 |
| 2 | Doxorubicin-loaded zein in situ gel for interstitial chemotherapy of colorectal cancer显示文摘The aim of this research was to evaluate doxorubicin(DOX)-loaded zein in situ gels,a new drug delivery system in which a liquid state drug can be transformed into semi-solid after intratumoral injection.In vitro release of DOX-loaded zein was investigated and the pharmacokinetics,biodistribution and therapeutic efficacy of these DOX-loaded zein formulations were investigated using BAI B/c nude tumor-bearing mice.In vitro release of DOX from the gels extended up to 7 days.Efficient accumulation of DOX in the tumor with lower drug concentration in blood and normal organs was obtained resulting in effective inhibition of tumor growth and fewer off-target side effects.In conclusion,a DOX-loaded in situ gel was developed with sustained release,enhanced anti-cancer efficacy for colorectal cancer in vivo,and especially with reduced off-target side effects. | Ning Shen Jie Hu Linan Zhang Li Zhang Yongjun Sun Yinghua Xie Shaomei Wu Lei Liu Zibin Gao | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 3 |
| 3 | Epigenetic modification associated with climate regulates betulin biosynthesis in birch显示文摘The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unclear.In this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence it.Whole-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast China.ZEB treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent manner.The methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic dose-response.In the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively correlated.Thus climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin biosynthesis.This study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production. | Jiang Wang Bowei Chen Shahid Ali Tianxu Zhang Yu Wang He Zhang Lishan Wang Yonglan Zhang Linan Xie Tingbo Jiang Jing Yin Heike W.Sederoff Gaurav Zinta Ronald R.Sederoff Yuhua Li Qingzhu Zhang | 2023 | Journal of Forestry Research2023，34，1： | 0 |
| 4 | Oxalic acid cross-linked sodium alginate and carboxymethyl chitosan hydrogel membrane for separation of dye/NaCl at high NaCl concentration显示文摘Dye desalination is a challenge in the treatment of textile wastewater with high salt concentration. It is imperative to develop salt resistance membrane that is from sustainable materials to effectively treat dye/salt mixtures. And most polymer membrane materials are non-renewable petrochemical resources.In this paper, a green hydrogel membrane(CMCS-OA-Na Alg) was prepared by non-metallic ions of oxalic acid(OA) cross-linking of two natural macromolecules of sodium alginate(Na Alg) and carboxymethyl chitosan(CMCS). The membrane showed excellent anti-swelling at high salt concentration(swelling rate less than 8.0% in 10.0 wt% Na Cl solution) and good anti-fouling performance. The membrane exhibited a rejection higher than 95.0% for dyes(bright blue, direct black, direct red, and Congo red) and lower than7.0% for Na Cl, which can achieve better dye/Na Cl separation performance. This study provides a promising membrane material for high salt textile wastewater treatment only using water and carbohydrates as raw materials without any organic solvents. | Wenbin Xie Kongyin Zhao Lijing Xu Ningning Gao Hui Zhao Zelong Gong Linan Yu Jun Jiang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
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