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| 1 | Radiofrequency ablation combined with transcatheter arterial chemoembolization therapy versus surgical resection for Barcelona-Clinic Liver Cancer(BCLC) A hepatocellular carcinoma: a meta-analysis显示文摘Purpose: The objective of our study was to compare the effectiveness of the combination of transcatheter arterial chemoembolization(TACE) and radiofrequency ablation(RFA) with that of surgical resection(SR) in Barcelona-Clinic Liver Cancer(BCLC) A hepatocellular carcinoma. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for comparisons of the two therapies from January 2006 to December 2017. Overall survival rate(OS), recurrence-free survival rate(RFS), complications, and the average length of hospital stay were compared and analyzed. Review Manager v. 5.2 from the Cochrane Collaboration was used for statistical analyses. Results: Seven case-control studies and one randomized controlled trial were identified, of which 717 were treated with a combination of TACE and RFA and 785 were treated with SR. Meta-analysis data revealed that TACE plus RFA had significantly better effectiveness on 1.0-y OS(OR = 0.50, p =.009). The major complications(ORcomplications = 1.88, p =.02) after the combined therapy were significantly lower than those after SR. There were three studies that reported the average length of hospital stay. The hospital stay for the SR group vs the combined therapy group was 19.8 ± 8.4 d vs 7.4 ± 2.2 d, respectively(p <.0001); 18.7 ± 4.9 d vs 11.5 ± 6.9 d, respectively(p <.0001); and 16.6 ± 6.7 d vs 8.5 ± 4.1 d, respectively(p <.0001). There was no significant difference in 3.0-or 5.0-y OS and 1.0-, 3.0-, or 5.0-y RFS. Conclusion: The combination of TACE and RFA has advantages in improving 1.0-y OS, reducing complications, and shortening the length of hospital stay over that of SR in the treatment of patients with BCLC A HCC. | Weidong Wang Sinan Hou Zelong Zhong JiaYan Ni Xiongying Jiang Dong Chen Yaoting Chen Jianghong Luo Hongliang Sun Linfeng Xu | 2018 | Journal of Interventional Medicine2018，1，1： | 9 |
| 2 | Very-High Color Rendering Index Hybrid White Organic Light-Emitting Diodes with Double Emitting Nanolayers显示文摘A very-high color rendering index white organic light-emitting diode(WOLED) based on a simple structure was successfully fabricated. The optimized device exhibits a maximum total efficiency of 13.1 and 5.4 lm/W at 1,000 cd/m2. A peak color rendering index of 90 and a relatively stable color during a wide range of luminance were obtained. In addition, it was demonstrated that the 4,40,400-tri(9-carbazoyl) triphenylamine host influenced strongly the performance of this WOLED.These results may be beneficial to the design of both material and device architecture for high-performance WOLED. | Baiquan Liu Miao Xu Lei Wang Hong Tao Yueju Su Dongyu Gao Linfeng Lan Jianhua Zou Junbiao Peng | 2014 | Nano-Micro Letters2014，6，4： | 4 |
| 3 | Trajectory prediction of ballistic missiles using Gaussian process error model显示文摘Ballistic Missile Trajectory Prediction(BMTP)is critical to air defense systems.Most Trajectory Prediction(TP)methods focus on the coast and reentry phases,in which the Ballistic Missile(BM)trajectories are modeled as ellipses or the state components are propagated by the dynamic integral equations on time scales.In contrast,the boost-phase TP is more challenging because there are many unknown forces acting on the BM in this phase.To tackle this difficult problem,a novel BMTP method by using Gaussian Processes(GPs)is proposed in this paper.In particular,the GP is employed to train the prediction error model of the boost-phase trajectory database,in which the error refers to the difference between the true BM state at the prediction moment and the integral extrapolation of the BM state.And the final BMTP is a combination of the dynamic equation based numerical integration and the GP-based prediction error.Since the trained GP aims to capture the relationship between the numerical integration and the unknown error,the modified BM state prediction is closer to the true one compared with the original TP.Furthermore,the GP is able to output the uncertainty information of the TP,which is of great significance for determining the warning range centered on the predicted BM state.Simulation results show that the proposed method effectively improves the BMTP accuracy during the boost phase and provides reliable uncertainty estimation boundaries. | Ruiping JI Yan LIANG Linfeng XU Zhenwei WEI | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 4 | Cryo-EM structure of human bile salts exporter ABCB11显示文摘Dear Editor,Bile is a complex aqueous secretion produced by the liver that facilitates the digestion of lipids in the small intestine.A group of ATP binding cassette(ABC)transporters localizing at the apical canalicular domain of hepatocytes are responsible for the secretion of the bile organic solutes to the bile canaliculi,1 including organic anions,cholesterol,bile salts,glutathione,organic cations and phospholipid(Fig.1a).To date,the 3-D structures of ABCG2,ABCG5/G8,ABCB1,ABCB4 have been reported,2'3 leaving the structures of ABCB11 and ABCC2 unknown,despite we can get some information from the homologous structures of ABCC1,4 ABCB1 and ABCB4. | Liang Wang Wen-Tao Hou Li Chen Yong-Liang Jiang Da Xu Linfeng Sun Cong-Zhao Zhou&Yuxing Chen | 2020 | Cell Research2020，30，7： | 2 |
| 5 | Cryo-EM structure of human lysosomal cobalamin exporter ABCD4显示文摘Dear Editor,Cobalamin,also known as vitamin B12,can only be biosynthesized by certain bacteria and archaea.As an essential nutrient for humans,it should be obtained from daily food.1 Exogenous cobalamin is taken up by the cell through an endocytosis process,then released into the lysosome as a free form,and finally pumped out to the cytosol for utilization.2 The human ATP-binding cassette(ABC)transporter ABCD4 localized on lysosomal membrane is indispensable for the efflux of cobalamin from lysosome to cytosol.3 Mutations in ABCD4 gene may result in cobalamin deficiency and inborn diseases.The patients suffer from combined symptoms:hypotonia,lethargy,poor feeding,bone marrow suppression,macrocytic anemia,and heart defects.3 However,the absence of the structure of human ABCD4 limits our understanding of the molecular mechanism of pathogenesis. | Da Xu Zhang Feng Wen-Tao Hou Yong-Liang Jiang Liang Wang Linfeng Sun Cong-Zhao Zhou Yuxing Chen | 2019 | Cell Research2019，29，12： | 2 |
| 6 | The effect of spacer in hybrid white organic light emitting diodes显示文摘Two kinds of highly efficient,bright hybrid white organic light emitting diodes have been fabricated by utilizing ambipolar material 4,4-N,N-dicarbazolebiphenyl(CBP)and unipolar material N,N0-di(naphthalene-1-yl)-N,N0-diphenyl-benzidine(NPB)as the spacer,respectively.By adjusting the thickness of spacers together with effectively utilizing combinations of exciton-harnessed orangephosphorescence/blue-fluorescence,the current efficiency of optimal device with CBP spacer and device with NPB spacer are 31.0 and 38.9 cd/A,the maximum power efficiency are 23.9 and 29.1 lm/W,the maximum brightness are 87,249 and 75,501 cd/m2,and the Commission Internationale de l’Eclairage(CIE)coordinates are(0.42,0.43)and(0.47,0.44)at a voltage of 11 V,respectively.Furthermore,systematic investigations focused on the effects of spacers on device performance have been performed.By virtue of the multifunctional spacer,energy transfer between the phosphorescent and fluorescent emitters can be avoided while the carriers still can pass through this spacer bridge,which is important to realize such high device performance.In addition,a novel concept that both ambipolar materials and unipolar materials can be the promising candidates for spacers has been proposed if the thickness of spacers with high triplet energy is optimized. | Baiquan Liu Miao Xu Hong Tao Yueju Su Dongyu Gao Jianhua Zou Linfeng Lan Junbiao Peng | 2014 | Chinese Science Bulletin2014，59，25： | 2 |
| 7 | Uterine artery chemoembolization treatment of placenta implantation combined safety and clinical efficacy of postpartum hemorrhage 显示文摘 | Yaoting Chen Linfeng Xu Hongliang Sun | 2010 | Chin J Obstet Gynecol2010，45，4： | 1 |
| 8 | Functions of non-coding RNAs in regulating cancer drug targets显示文摘With the development of precision medicine,the efficiency of tumor treatment has been significantly improved.More attention has been paid to targeted therapy and immunotherapy as the key to precision treatment of cancer.Targeting epidermal growth factor receptor(EGFR)has become one of the most important targeted treatments for various cancers.Comparing with traditional chemotherapy drugs,targeting EGFR is highly selective in killing tumor cells with better safety,tolerability and less side effect.In addition,tumor immunotherapy has become the fourth largest tumor therapy after surgery,radiotherapy and chemotherapy,especially immune checkpoint inhibitors.However,these treatments still produce a certain degree of drug resistance.Non-coding RNAs(ncRNAs)were found to play a key role in carcinogenesis,treatment and regulation of the efficacy of anticancer drugs in the past few years.Therefore,in this review,we aim to summarize the targeted treatment of cancers and the functions of ncRNAs in cancer treatment. | Binshu Chai Zhongliang Ma Xianyi Wang Linfeng Xu Yanli Li | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 1 |
| 9 | Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets显示文摘Dear Editor,Bile acids are a group of cholesterol-derived physiological surfactants required for digestion of lipids and fat-soluble vitamins.1However,excess of bile acids is detrimental to metabolic homeostasis and bile acid imbalance can contribute to cancer progression.2Bile acids are produced primarily in the liver and then secreted to the bile duct before delivery to the small intestine,where up to 95%of bile acids are reabsorbed and recirculated to the liver(Supplementary information,Fig.S1a).The primary bile acids are biosynthesized in hepatocytes via oxidation of cholesterol and modified by either taurine or glycine,forming the conjugated primary bile acids which harbor a cholic acid moiety and a taurine/glycine moiety(Supplementary information,Fig.S1 b).This enterohepatic circulation of bile acids is driven by a series of transmembrane transporters(Supplementary informa-tion,Fig.S1a),including the ATP-binding cassette(ABC)transpor-ter ABCB11(also termed bile salt export pump BSEP). | Liang Wang Wen-Tao Hou Jie Wang Da Xu Cong Guo Linfeng Sun Ke Ruan Cong-Zhao Zhou Yuxing Chen | 2022 | Cell Research2022，32，5： | 1 |
| 10 | Saliency detection using joint spatial-color constraint and multi-scale segmentation显示文摘 | Xu Linfeng Li Hongliang Zeng Liaoyuan | 2013 | Journal of Visual Communication and Image Representation2013，24，4： | 1 |
| 11 | Modeling and state estima-tion for dynamic systems with linear equality con-straints 显示文摘 | Xu Linfeng Li X R | 2013 | IEEE Transactions on Signal Pro-cessing2013，61，11： | 1 |
| 12 | Characteristics of low altitude ionospheric electric field over Hainan Island,China显示文摘A sounding rocket experiment undertaken by the Chinese Meridian Project from a low latitude station on Hainan Island(19.5°N,109.1°E),China,measured the DC electric field during 05:45-05:52 LT on April 5,2013.The data observed using a set of electric field double probes,as part of the rocket's scientific payload,revealed the special profile of how the vectors of the DC electric field vary with altitude between 130 and 190 km.During the experiment,the vertical electric field was downward,and the maximum vertical electric field was nearly 5.1 mV/m near the altitude of 176 km.The zonal electric field was eastward and slightly less than 0.6 mV/m.The plasma drift velocity was estimated from the E×B motion,and the zonal drift velocity was eastward and of the order of 100 m/s.The zonal wind velocity was also estimated using the drift velocity near the maximum density height in the F1-region,and it was found to be nearly 120 m/s.This work constituted the first in situ measurement of the DC electric field conducted within the Fl-region(between 130 and 190 km) in the East Asian Sector. | LI RenKang CHEN Tao MAN Feng JIANG XiuJie LUO Jing HE ZhaoHai ZHANG HuiMing WANG LinFeng LIU Cheng Francisco Carlos de MENESES WANG GuoJun XU JiYao | 2017 | Science China Earth Sciences2017，60，4： | 1 |
| 13 | Face hallucination via similarity constraints 显示文摘 | Li Hongliang Xu Linfeng Liu Guanghui | 2013 | IEEE Signal Processing Letters2013，20，1： | 1 |
| 14 | Integrating bottom-up and top-down visual stimulus for saliency detection in news video显示文摘 | Wu Bo Xu Linfeng | 2014 | Multimedia Tools and Applications2014，73，3： | 1 |
| 15 | Saliency detection using joint spatial-color constraint and multi-scale segmentation显示文摘 | Xu Linfeng Li Hongliang Zeng Liaoyuan | 2013 | Journal of Visual Communication and Image Representation2013，24，4： | 1 |
| 16 | Laparoscopic radiofrequency ablation?assisted enucleation of Xp11.2translocation renal cell carcinoma: A case report显示文摘 | Linfeng Xu Rong Yang Wei Wang Yifen Zhang Weidong Gan | 2014 | Oncology Letters2014，，3： | 1 |
| 17 | Two-layer Aver- age-to-peak Ratio Based Saliency Detection 显示文摘 | LI Hongliang XU Linfeng LIU Guanghui | 2013 | Signal Processing:Image Communication2013，28，： | 1 |
| 18 | Microcellular foamed polyamide 6/carbon nanotube composites withsuperior electromagnetic wave absorption显示文摘Electromagnetic (EM) wave pollution causing damage to precision equipment and threatening thehealth of living organisms has attracted considerable attention. Herein, promising microcellular foamedpolyamide 6 (PA6)/carbon nanotube (CNT) composites for highly efficient EM wave absorption were successfully fabricated using supercritical CO_(2) foaming. Nanocomposites foams with a void fraction rangingfrom 38.7% to 85.1% were achieved, providing a platform to assess the correlation of the electrical conductivity, the dielectric permittivity and the EM wave absorption properties with porosity. Notably, theFoam-257.5C sample with a void fraction of 38.7% exhibited outstanding EM wave absorption characteristics at a thickness of only 1.59 mm and an ultra-low reflection loss value of -55.3 dB (99.9997% wave absorption). Most importantly, the effective absorption bandwidth (EAB) of the Foam-257.5C sample couldcover the entire Ku band (12.4–18 GHz) by slightly adjusting the thickness from 1.20 to 1.60 mm. Thesuperior EM wave absorption performance of the Foam-257.5C sample was attributed to multiple reflections and scattering at the solid-gas interfaces, favorable impedance matching due to the existence ofa large polymer-air interface area, conductive loss near the interfaces and interfacial polarization. Thus,this study offers an eco-friendly, simple and versatile methodology to develop high-efficiency, flexiblepolymer-based EM wave absorbents. | Menglong Xu Linfeng Wei Li Ma Jiawei Lu Tao Liu Ling Zhang Ling Zhao Chul B.Park | 2022 | Journal of Materials Science & Technology2022，，22： | 1 |
| 19 | Modeling and state estimation for dynamic systems with linear equality constraints显示文摘 | Xu Linfeng Rong X Li F | 2013 | IEEE Transactions on Signal Processing2013，61，11： | 1 |
| 20 | Lycium ruthenicum Murr. treatment attenuates APP_(SWE)/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model显示文摘Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease(AD). However, it is unclear whether different mouse models with mitochondrialrelated diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APP_(SWE)/PS1ΔE9 transgenic mouse were examined using transmission electron microscope(TEM). Both young Slc25a46 knockout mice and aged APP_(SWE)/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD. | Min Wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao Maojin Yao Jiaoyan Ren | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
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