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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Spatio-temporal Variation of Wind Erosion in Inner Mongolia of China Between 2001 and 2010显示文摘Using Geographic Information System(GIS), based on wind speed, precipitation, topographic, soil, vegetation coverage and land use data of Inner Mongolia between 2001 and 2010, we applied the revised wind erosion equation(RWEQ) model to simulate wind erosion intensity. The results showed that an area of approximately 47.8 × 10~4 km^2 experienced wind erosion in 2010, 23.2% of this erosion could be rated as severe, and 46.0% as moderate. Both the area and the intensity of wind erosion had decreased from 2001 to 2010, the wind erosion area reduced 10.1%, and wind erosion intensity decreased by 29.4%. Precipitation, wind speed, population size and urbanization in rural areas, and gross domestic product of primary industry(GDP1) were the main factors influencing wind erosion. Overall, these factors accounted for 88.8% of the wind erosion. These results indicated that the decrease in wind erosion over the past decade related to the increase in precipitation and the decrease in the number of windy days, while modest urban development and optimization of the economic structure might partially reduced the level of ecological pressure, highlighting the importance of human activities in controlling wind erosion. | JIANG Ling XIAO Yi ZHENG Hua OUYANG Zhiyun | 2016 | Chinese Geographical Science2016，26，2： | 11 |
| 3 | Early prediction of pathological outcomes to neoadjuvant chemotherapy in breast cancer patients using automated breast ultrasound显示文摘Objective: Early assessment of response to neoadjuvant chemotherapy(NAC) for breast cancer allows therapy to be individualized.The optimal assessment method has not been established.We investigated the accuracy of automated breast ultrasound(ABUS) to predict pathological outcomes after NAC.Methods: A total of 290 breast cancer patients were eligible for this study.Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters(PC) or the longest diameter change(LDC).PC and LDC were analyzed on the axial and the coronal planes respectively.Receiver operating characteristic(ROC) curves were used to evaluate overall performance of the prediction methods.Youden's indexes were calculated to select the optimal cut-off value for each method.Sensitivity, specificity,positive and negative predictive values(PPV and NPV) and the area under the ROC curve(AUC) were calculated accordingly.Results: yp T0/is was achieved in 42 patients(14.5%) while yp T0 was achieved in 30 patients(10.3%) after NAC.All four prediction methods(PC on axial planes, LDC on axial planes, PC on coronal planes and LDC on coronal planes) displayed high AUCs(all>0.82), with the highest of 0.89 [95% confidence interval(95% CI), 0.83–0.95]when mid-treatment ABUS was used to predict final pathological complete remission(p CR).High sensitivities(85.7%–88.1%) were observed across all four prediction methods while high specificities(81.5%–85.1%) were observed in two methods used PC.The optimal cut-off values defined by our data replicate the WHO and the RECIST criteria.Lower AUCs were observed when mid-treatment ABUS was used to predict poor pathological outcomes.Conclusions: ABUS is a useful tool in early evaluation of p CR after NAC while less reliable when predicting poor pathological outcomes. | Xinguang Wang Ling Huo Yingjian He Zhaoqing Fan Tianfeng Wang Yuntao Xie Jinfeng Li Tao Ouyang | 2016 | Chinese Journal of Cancer Research2016，28，5： | 11 |
| 4 | Expression and significance of lysyl oxidase-like 1 and fibulin-5 in the cardinal ligament tissue of patients with pelvic floor dysfunction显示文摘Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support,leading to the herniation of the uterus into or through the vagina.POP is a complex problem that likely involves multiple mechanisms with limited therapies available,and is associated with defects in connective tissue including elastic fibers.This study was designed to investigate the expression of fibulin-5 and lysyl oxidase-like 1 (LOXL1) in the cardinal ligament in samples taken from the POP group compared to the non-POP group.Specimens were obtained during abdominal hysterectomy from the cardinal ligament of 53 women with POP and 25 age-and parity-matched women with non-POP among post-menopausal women with benign gynecologic pathology.Protein expression was evaluated using the immunohistochemical staining method.For statistical analyses,chi-square test and Spearman's correlation were used with the statistical package SPSS13.0 system.Our results showed that both fibulin-5 and LOXL1 expressions were decreased in the cardinal ligament in the POP group compared to the nonPOP group (P < 0.05).The expression of fibulin-5 and LOXL1 were correlated closely with the stage of POP,accompanied by stress urinary incontinence and frequency of vaginal delivery (P < 0.05),but had no relationship with post-menopausal state (P > 0.05).The expression of fibulin-5 was positively associated with LOXL1 in POP (P < 0.05).We conclude that changesin fibulin-5and LOXL1expression may playa role in the development of POP. | Yang Zhou Ouyang Ling Li Bo | 2013 | The Journal of Biomedical Research2013，27，1： | 10 |
| 5 | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway显示文摘Whether and how garlic-derived S-allylmercaptocysteine(SAMC) inhibits hepatocellular carcinoma(HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor(LDLR)-related protein 6(LRP6) in HCC progression and the anti-HCC mechanism of SAMC was examined in clinical sample, cell model and xenograft/orthotopic mouse models. We demonstrated that SAMC inhibited cell proliferation and tumorigenesis, while induced apoptosis of human HCC cells without influencing normal hepatocytes. SAMC directly interacted with Wnt-pathway co-receptor LRP6 on the cell membrane. LRP6 was frequently over-expressed in the tumor tissue of human HCC patients(66.7% of 48 patients) and its overexpression only correlated with the over-expression of β-catenin, but not with age, gender, tumor size, stage and metastasis. Deficiency or over-expression of LRP6 in hepatoma cells could partly mimic or counteract the anti-tumor properties of SAMC, respectively. In vivo administration of SAMC significantly suppressed the growth of Huh-7 xenograft/orthotopic HCC tumor without causing undesirable side effects. In addition, stable down-regulation of LRP6 in Huh-7 facilitated the anti-HCC effects of SAMC. In conclusion, LRP6 can be a potential therapeutic target of HCC. SAMC is a promising specific anti-tumor agent for treating HCC subtypes with Wnt activation at the hepatoma cell surface. | Jia Xiao Feiyue Xing Yingxia Liu Yi Lv Xiaogang Wang Ming-Tat Ling Hao Gao Songying Ouyang Min Yang Jiang Zhu Yu Xia Kwok-Fai So George L.Tipoe | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 6 | Insight into the catalytic activity of MXenes for hydrogen evolution reaction显示文摘MXenes have exhibited great potential as cost-effective electrocatalysts for hydrogen evolution reaction(HER). However, insight into the origin of activity is still missing. Herein, on the basis of a systematical investigation of the HER performance of 20 MXenes(M_2NO_2 and M_2CO_2, M = Sc, Ti, V, Cr, Zr, Nb, Mo,Hf, Ta and W), a Fermi-abundance model is proposed to understand variation of the activity in different MXenes. It is found that the occupied p electronic states of surface O atoms play a decisive role in the HER activity of MXenes. More importantly, Ti_2NO_2 and Nb_2NO_2 are found to be promising HER electrocatalysts with the free energy for hydrogen adsorption close to zero. This work not only provides possible catalysts for HER, the developed Fermi-abundance model but also is applicable to other two-dimensional materials and may serve as a simple descriptor of the intrinsic HER activity. | Xiaowan Bai Chongyi Ling Li Shi Yixin Ouyang Qiang Li Jinlan Wang | 2018 | Science Bulletin2018，63，21： | 6 |
| 7 | Qualitative detection of ginsenosides in brain tissues after oral administration of high-purity ginseng total saponins by using polyclonal antibody against ginsenosides显示文摘Given the limited studies and conflicting findings, the transport character of ginsenosides crossing the blood–brain barrier(BBB) remains unclear. The present study was designed to qualitatively determine the distribution of ginsenosides in brain tissues after oral administration of ginseng total saponins, using high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) combined with immunohistochemistry. In brain tissue homogenates, ginsenoside Rg1 was detectable and no other ginsenosides or their metabolites were found. No ginsenosides were detected in cerebrospinal fluid. Immunohistochemistry staining of brain tissue sections by using anti-ginsenoside polyclonal antibodies revealed the localization of ginsenosides in brain tissues. Furthermore, immunofluorescence double staining revealed that ginsenosides widely existed in vascular endotheliocytes and astrocytes, and in few neurons. These results indicated that Rg1 was the main component that entered the brain after oral administration of ginseng total saponins and that ginsenosides could cross the BBB, although the transport capability of ginsenosides through the BBB may be poor. | ZHAO Yu-Nan SHAO Xiao OUYANG Liu-Feng CHEN Lin GU Ling | 2018 | Chinese Journal of Natural Medicines2018，16，3： | 4 |
| 8 | Discrimination of toxic ingredient between raw and processed Pinellia ternata by UPLC/Q-TOF-MS/MS with principal component analysis and T-test显示文摘Objective: To investigate the toxicity difference between raw and processed Pinelliae Rhizoma(Banxia in Chinese, BX), the rhizoma of Pinellia ternata, from the view of chemical composition.Methods: Sixteen samples of raw and processed BX were prepared and analyzed by UPLC/Q-TOF-MS/MS.The discrimination(chemical marker) between the two group was investigated by principal component analysis(PCA) and T-test analysis. According to the accurate charge-to-mass ratio, MS/MS fragments, and comparison of corresponding data with the reference or database, the chemical markers were identified preliminarily.Results: Liquiritin, liquiritigenin, and lysophosphatidylcholine(LPC) were identified as the characteristic markers. The reducing of LPC in processed BX was one of the main reasons for detoxification because LPC could induce the inflammatory response;Liquiritin and liquiritigenin showed the anti-inflammatory effect and reduced liver injury, therefore the appearance of them in processed BX was an another reason for detoxification.Conclusion: An approach to explain the mechanisms of reducing the toxicity in medicinal plants by processing was proposed. Moreover, the chemical markers of toxicity could be used to differentiate the raw material from processed herbs for the quality control and safety application in clinical practice. | Xing-ying Zhai Ling Zhang Bing-tao Li Yu-lin Feng Guo-liang Xu Hui Ouyang Shi-lin Yang Chen Jin | 2019 | Chinese Herbal Medicines2019，11，2： | 4 |
| 9 | Upper embeddability,edge independence number and girth显示文摘Combined with the edge-connectivity, this paper investigates the relationship between the edge independence number and upper embeddability. And we obtain the following result: Let G be a k-edge-connected graph with girth g. If α '(G)≤((k-1)2+2) [g/2]+(1-(-1)n)/2((k-1)(k-2)+1)-1,where k =1, 2, 3, and α (G) denotes the edge independence number of G, then G is upper embeddable and the upper bound is best possible. And it has generalized the relative results. | OUYANG ZhangDong TANG Ling HUANG YuanQiu | 2009 | Science China Mathematics2009，52，9： | 2 |
| 10 | Resonance Scattering Effect of Dopamine Product Particle and Its Application to Polyphenoloxidase Activity Assay显示文摘在 pH 7.2 Na2HPO4-NaH2PO4 缓冲区答案, polyphenoloxidase (PPO ) 能催化多巴胺(DA ) 的氧化在黑暗红的颜色形成聚合物粒子,它展出了散布的强壮的回声(RS ) 在 780 nm 的山峰。处于选择条件,当 PPO 活动增加了,在 780 nm 的 RS 紧张线性地增加了。增加的 RS 紧张(I780 nm ) 对在 0.106.0 U 的范围的 PPO | Jiang, Caina Ling, Shaoming Liang, Aihui Ouyang, Huixiang Wang, Pengfei Jiang, Zhiliang | 2011 | Chinese Journal of Chemistry2011，29，3： | 2 |
| 11 | Increasing Fatty Acids in Rice Root Improves Silence of Rice Seedling to Salt Stress显示文摘Salt stress is one of the major abiotic stresses around the world, and salt salinity is one of the major constrains affecting rice production (Tu et al, 2014;Reddy et al, 2017). According to the statistics, more than one billion hectares of the land in the major continents are affected by salinity (Fageria et al, 2012;Zhou et al, 2018). Rice is a salt sensitive crop, considered more sensitive to salt stress during early stage (Hasanuzzaman et al, 2009). Understanding the method to improve plant salt tolerance is a potential way to enhance agriculture productivity in the future (Jing and Zhang, 2017). Polyunsaturated fatty acid (PUFA) on plasma membrane plays important roles in salt tolerance through enhancing the activity of Na^+/H^+ transporters (López-Pérez et al, 2009). | LIU Ling CHEN Jin TAN Yanning ZHOU Tianshun OUYANG Ning ZENG Jia YUAN Dingyang DUAN Meijuan | 2019 | Rice science2019，26，6： | 2 |
| 12 | The Crossing Numbers of Cartesian-Products of Stars and 5-Vertex Graphs显示文摘In this paper, the crossing numbers of the Cartesian products of a specific 5-vertex graph with a star are given, and thus the result fills up the crossing number list of Cartesian products of all 5-vertex graphs with stars (presented by Marián Kle). In addition, we also give an up to date description of Cartesian products of 5-vertex graphs with stars, whose crossing numbers are known. | HE Pei Ling QIAN Chun Hua OUYANG Zhang Dong HUANG Yuan Qiu | 2009 | Journal of Mathematical Research and Exposition2009，29，2： | 2 |
| 13 | Activation of MAPK signaling pathway is essential for Id - 1 induced serum independent prostate cancer cell growth 显示文摘 | Ling MT Wang X Ouyang XS | 2002 | Oncogene2002，21，55： | 1 |
| 14 | Id -1 expression promotes cell survival through activation of NF -kappaB sig- nalling pathway in prostate cancer cells 显示文摘 | LING MT WANG X OUYANG XS | 2003 | Oncogene2003，22，29： | 1 |
| 15 | Impacts of simu- lated acid rain on cation leaching from the Latosol in south China 显示文摘 | Zhang J E Ouyang Y Ling 1) J | 2007 | Chemosphere2007，67，： | 1 |
| 16 | Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway 显示文摘 | Wang X Ling MT | 2002 | Carcinogenesis2002，23，5： | 1 |
| 17 | Id-1 expression promotes cell survival through activation of NF-kappaB signaling pathway in prostate cancer cells显示文摘 | Ling MT Wang X Ouyang XS | 2003 | Oncogene2003，22，29： | 1 |
| 18 | Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of P16INK4a/pRB pathway 显示文摘 | Ouyang XS Wang X Ling MT | 2002 | Carcinogenesis2002，23，： | 1 |
| 19 | Determination of octylphenol and nonylphenol in aqueous sample using simultaneous derivatization and dispersive liquid–liquid microextraction followed by gas chromatography–mass spectrometry显示文摘 | Shusheng Luo Ling Fang Xiaowei Wang Hongtao Liu Gangfeng Ouyang Chongyu Lan Tiangang Luan | 2010 | Journal of Chromatography A2010，，43： | 1 |
| 20 | Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16INK4a/pRB pathway显示文摘 | Ouyang XS Wang X Ling MT | 2002 | Carcinogenesis2002，23，5： | 1 |
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